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Table 1 Demographic, clinical characteristics, and laboratory exams upon hospital presentation of the pregnant patients included in the validation analysis

From: Mechanical ventilation and death in pregnant patients admitted for COVID-19: a prognostic analysis from the Brazilian COVID-19 registry score

Characteristics

Overall

Death

Hospital discharge

p-value*

Statistic

n = 350a

Statistic

n = 21a

Statistic

n = 329a

Age (years)

30.0 (25.2, 35.0)

350 (100%)

34.0 (28.0, 38.0)

21 (100%)

30.0 (25.0, 35.0)

329 (100%)

0.014

Comorbidities

 Hypertension

39 (11.1%)

350 (100%)

8 (38.1%)

21 (100%)

31 (9.4%)

329 (100%)

< 0.001

 Diabetes mellitus

32 (9.1%)

350 (100%)

3 (14.3%)

21 (100%)

29 (8.8%)

329 (100%)

0.424

 Obesity (BMI ≥ 30 kg/m2)

41 (11.7%)

350 (100%)

6 (28.6%)

21 (100%)

35 (10.6%)

329 (100%)

0.025

Symptomsb

 None

14 (4.0%)

350 (100%)

0 (0.0%)

21 (100%)

14 (4.3%)

329 (100%)

> 0.999

 Adynamic

40 (11.4%)

350 (100%)

3 (14.3%)

21 (100%)

37 (11.2%)

329 (100%)

0.720

 Ageusia

44 (12.6%)

350 (100%)

1 (4.8%)

21 (100%)

43 (13.1%)

329 (100%)

0.493

 Anosmia

60 (17.1%)

350 (100%)

4 (19.0%)

21 (100%)

56 (17.0%)

329 (100%)

0.768

 Headache

94 (26.9%)

350 (100%)

4 (19.0%)

21 (100%)

90 (27.4%)

329 (100%)

0.563

 Rhinorrhea

76 (21.7%)

350 (100%)

3 (14.3%)

21 (100%)

73 (22.2%)

329 (100%)

0.586

 Diarrhea

20 (5.7%)

350 (100%)

1 (4.8%)

21 (100%)

19 (5.8%)

329 (100%)

> 0.999

 Dyspnea

195 (55.7%)

350 (100%)

13 (61.9%)

21 (100%)

182 (55.3%)

329 (100%)

0.717

 Sore throat

35 (10.0%)

350 (100%)

1 (4.8%)

21 (100%)

34 (10.3%)

329 (100%)

0.708

 Fever

166 (47.4%)

350 (100%)

8 (38.1%)

21 (100%)

158 (48.0%)

329 (100%)

0.510

 Hyporexia

16 (4.6%)

350 (100%)

1 (4.8%)

21 (100%)

15 (4.6%)

329 (100%)

> 0.999

 Myalgia

118 (33.7%)

350 (100%)

11 (52.4%)

21 (100%)

107 (32.5%)

329 (100%)

0.103

 Nausea/vomiting

43 (12.3%)

350 (100%)

3 (14.3%)

21 (100%)

40 (12.2%)

329 (100%)

0.732

 Productive cough

164 (46.9%)

350 (100%)

9 (42.9%)

21 (100%)

155 (47.1%)

329 (100%)

0.878

Clinical presentation

 Glasgow coma score = 15

318 (100.0%)

 

14 (100.0%)

 

304 (100.0%)

  

 Respiratory rate (irpm)

22.0 (19.0, 26.2)

252 (72%)

23.0 (19.0, 32.5)

12 (57%)

22.0 (19.0, 26.0)

240 (73%)

0.394

 SF ratio

457.1 (405.5, 466.7)

298 (85%)

333.0 (98.2, 456.0)

14 (67%)

457.1 (419.0, 466.7)

284 (86%)

0.002

 Heart rate (bpm)

100.0 (88.0, 111.0)

311 (89%)

102.0 (87.5, 111.5)

15 (71%)

100.0 (88.0, 110.5)

296 (90%)

0.945

 Systolic blood pressure

 

314 (90%)

 

15 (71%)

 

299 (91%)

> 0.999

  ≥ 90 (mmHg)

305 (97.1%)

 

15 (100.0%)

 

290 (97.0%)

  

 Inotrope requirement

3 (1.0%)

   

3 (1.0%)

  

 Diastolic blood pressure

 

313 (89%)

 

15 (71%)

 

298 (91%)

0.248

  ≤ 60 (mmHg)

76 (24.3%)

 

1 (6.7%)

 

75 (25.2%)

  

 Inotrope requirement

3 (1.0%)

   

3 (1.0%)

  

Laboratory exams

 Hemoglobin (g/L)

11.7 (10.8, 12.6)

297 (85%)

11.9 (11.2, 12.4)

14 (67%)

11.7 (10.8, 12.6)

283 (86%)

0.534

 Platelet count (109/L)

199,000.0 (162,000.0, 250,500.0)

295 (84%)

224,500.0 (170,500.0, 265,500.0)

14 (67%)

198,000.0 (162,000.0, 250,000.0)

281 (85%)

0.447

 NL ratio

5.3 (3.5, 8.4)

294 (84%)

8.1 (5.5, 12.5)

14 (67%)

5.3 (3.5, 8.3)

280 (85%)

0.034

 Lactate value

1.1 (0.8, 1.5)

143 (41%)

1.2 (1.1, 1.4)

10 (48%)

1.1 (0.8, 1.5)

133 (40%)

0.557

 C reactive protein (mg/L)

47.0 (18.5, 88.0)

249 (71%)

47.9 (18.9, 90.6)

10 (48%)

47.0 (18.5, 86.1)

239 (73%)

0.750

 Urea (mg/dL)

13.3 (10.0, 17.6)

231 (66%)

9.8 (8.0, 18.5)

10 (48%)

13.3 (10.0, 17.3)

221 (67%)

0.324

 Creatinine (mg/dL)

0.6 (0.5, 0.7)

255 (73%)

0.5 (0.4, 0.7)

11 (52%)

0.6 (0.5, 0.7)

244 (74%)

0.571

 pH

7.4 (7.4, 7.5)

168 (48%)

7.4 (7.4, 7.4)

9 (43%)

7.4 (7.4, 7.5)

159 (48%)

0.310

 Arterial pO2

85.0 (70.0, 110.2)

168 (48%)

69.0 (52.0, 72.0)

9 (43%)

86.0 (71.3, 111.0)

159 (48%)

0.004

 Arterial pCO2

29.0 (25.5, 31.0)

169 (48%)

28.9 (28.4, 31.0)

9 (43%)

29.0 (25.3, 31.0)

160 (49%)

0.188

Outcomes

 Intensive care unit

113 (32.3%)

350 (100%)

19 (90.5%)

21 (100%)

94 (28.6%)

329 (100%)

< 0.001

 Dialysis

14 (4.0%)

350 (100%)

6 (28.6%)

21 (100%)

8 (2.4%)

329 (100%)

< 0.001

 Mechanical ventilation

68 (19.7%)

346 (99%)

18 (85.7%)

21 (100%)

50 (15.4%)

325 (99%)

< 0.001

 Intra-hospital mortality

21 (6.0%)

350 (100%)

21 (100.0%)

21 (100%)

0 (0.0%)

329 (100%)

< 0.001

  1. BMI body mass index, HCO3− bicarbonate, NL ratio neutrophils-to-lymphocytes ratio, pH hydrogen potential, pCO2 carbon dioxide partial pressure, pO2 oxygen partial pressure, SpO2/FiO2 ratio peripheral oxygen saturation to fraction of inspired oxygen ratio
  2. *Statistical tests performed: Wilcoxon rank-sum test; Fisher’s exact test; chi-square test of independence
  3. aStatistics presented: Median (IQR); n (%)
  4. bThere was no patient with neurological symptoms, arthralgia or skin rash
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