Input parameter | Base-case value | Upper limit | Lower limit | Source |
---|---|---|---|---|
Age start | 21Â years a | 16.8 | 25.2 | [29] |
The proportion of PPH cases that are atonic | 0.80 a | 0.64 | 0.96 | [37] |
The relative risk of further interventions with TXA | 0.96 a | 0.76 | 1.15 | Calculated from [32] |
The relative risk of further interventions with SOC | 1.05 | 0.84 | 1.26 | Calculated from [32] |
Risk of further intervention events with TXA | 0.22 | 0.18 | 0.27 | Calculated from [32] |
Risk of further intervention events with SOC | 0.23 a | 0.19 | 0.28 | Calculated from [32] |
UBT insertion for atonic PPH at primary | 0.19 a | 0.15 | 0.22 | [29] |
UBT insertion for atonic PPH at secondary | 0.33 a | 0.26 | 0.40 | [29] |
UBT insertion for atonic PPH at tertiary | 0.48 a | 0.39 | 0.58 | [29] |
Clinical effectiveness of condom-UBT | 0.92 a | 0.74 | 0.98 | [35] |
The relative risk for death due to bleeding with TXA | 0.69 | 0.52 | 0.91 | Calculated from [32] |
Risk of death due to bleeding with standard care (SOC) | 0.02 a | 0.01 | 0.02 | Calculated from [32] |
Direct hysterectomy for uncontrolled atonic PPH after UBT intervention | 0.15 a | 0.12 | 0.18 | [34] |
Hysterectomy after devascularization | 0.22 a | 0.18 | 0.26 | [34] |
The relative risk for all-cause mortality with TXA | 0.88 | 0.74 | 1.05 | Calculated from [32] |
Risk of all-cause mortality rate with standard care | 0.03 a | 0.02 | 0.03 | Calculated from [32] |
Risk of ICU admission for UBT uncontrolled cases | 0.77 a | 0.62 | 0.92 | [36] |
Risk of ICU admission for UBT-controlled cases | 0.03 a | 0.02 | 0.03 | [36] |
Traumatic PPH controlled with suturing and local measures | 0.45 a | 0.36 | 0.55 | [34] |
Cost of medical management with TXA at the primary level | 451 | 353 | 560 | From the Primary costing study |
Cost of medical management with TXA at the secondary level | 1685 | 1405 | 1945 | |
Cost of medical management with TXA at tertiary level | 2812 | 2433 | 3176 | |
Cost of medical management with SOC at the primary level | 241 | 139 | 353 | |
Cost of medical management with SOC at the secondary level | 1475 | 1207 | 1740 | |
Cost of medical management with SOC at tertiary | 2601 | 2171 | 3053 | |
Cost of UBT insertion for atonic PPH at the primary level | 281 | 254 | 308 | |
Cost of UBT insertion for atonic PPH at the secondary level | 531 | 446 | 618 | |
Cost of UBT insertion for atonic PPH at tertiary level | 1303 | 1170 | 1433 | |
Cost of devascularisation surgery at the secondary level | 4991 | 3986 | 5997 | |
Cost of devascularisation surgery at tertiary level | 8271 | 6483 | 10,109 | |
Cost of hysterectomy at the secondary level | 7535 | 6150 | 9016 | |
Cost of hysterectomy at tertiary level | 11,462 | 9529 | 13,343 | |
Cost of indoor patient (IPD) admission for PPH at the secondary level | 2230 | 1290 | 3310 | |
Cost of IPD admission for PPH at tertiary level | 3273 | 2387 | 4236 | |
Cost of ICU admission for PPH at the tertiary level | 9901 | 4759 | 15,731 | |
Cost of local management for traumatic at primary | 264 | 177 | 351 | |
Cost of local management for traumatic at secondary | 387 | 302 | 470 | |
Cost of local management for traumatic at tertiary | 689 | 532 | 851 | |
Cost of patient referral | 1096 a | 876 | 1315 | [38] |
Out-of-pocket expenditure for childbirth | 3015 a | 2412 | 3618 | [39] |
Number of TXA doses | 1.29 | 1.28 | 1.30 | [40] |
Utility at death | 0.00 | 0 | 0 | Â |
Utility at discharge (medical management) | 0.930 | 0.910 | 0.940 | [40] |
Utility for medical plus conservative measures | 0.895 | 0.892 | 0.897 | [40] |
Utility short-term devascularization (42Â days) | 0.565 a | 0.300 | 0.870 | [41] |
Utility devascularization long term (Beyond 42Â days) | 0.909 | 0.500 | 0.960 | [41] |
Utility hysterectomy short-term (42Â days) | 0.560 a | 0.448 | 0.672 | [42] |
Utility hysterectomy long-term (beyond 42) | 0.880 a | 0.704 | 1.000 | [42] |
Utility ICU admission (1.5Â days) | 0.490a | 0.392 | 0.588 | [42] |
Discount rate | 0.030 | 0.000 | 0.050 | [43] |