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Table 2 Comparison of clinical outcomes between EFPL and GnRH-Ant regimens before and after PS matching

From: Comparison of clinical effects between early follicular prolonged GnRH agonist protocol and GnRH antagonist protocol in 3310 cycles: a retrospective study

 

Before matching

  

After matching

  

Parameter

EFPL

GnRH-Ant

P

EFPL

GnRH-Ant

P

Number of fresh embryo transfer cycles

967

710

 

166

166

 

Number of embryos transferred

  

< 0.001

  

0.43

 1

32.06 (310/967)

17.46 (124/710)

 

24.70 (41/166)

21.08 (35/166)

 

 2

67.94 (657/967)

82.54 (586/710)

 

75.30 (125/166)

78.92 (131/166)

 

Type of embryo transferred

  

< 0.001

  

0.01

 Cleavage embryo

56.15 (543/967)

85.49 (607/710)

 

63.86 (106/166)

76.51 (127/166)

 

 Blastocyst

43.85 (424/967)

14.65 (104/710)

 

36.14 (60/166)

23.49 (39/166)

 

Number of good embryos transferred

  

< 0.001

  

0.16

 0

14.99 (145/967)

9.58 (68/710)

 

12.65 (21/166)

6.63 (11/166)

 

 1

34.23 (331/967)

29.01 (206/710)

 

28.92 (48/166)

28.92 (48/166)

 

 2

50.78 (491/967)

61.41 (436/710)

 

58.43 (97/166)

64.46 (107/166)

 

Chemical pregnancy rate per cycle

67.94 (657/967)

49.86 (354/710)

< 0.001

65.06 (108/166)

48.80 (81/166)

< 0.01

Clinical pregnancy rate per cycle

58.12 (562/967)

41.27 (293/710)

< 0.001

56.02 (93/166)

38.55 (64/166)

< 0.01

Live birth rate per cycle

41.54 (356/857)

25.90 (166/641)

< 0.001

39.49 (62/157)

29.03 (45/155)

0.05

Twin pregnancy rate

21.35 (76/356)

22.29 (37/166)

0.81

19.35 (12/62)

11.11 (5/45)

0.25

Miscarriage rate

15.73 (87/553)

17.54 (50/285)

0.50

21.11 (19/90)

11.11 (7/63)

0.10

Pregnancy type

  

0.42

  

0.89

 Intrauterine pregnancy

98.04 (551/562)

96.59 (283/293)

 

96.77 (90/93)

98.44 (63/64)

 

 Heterotopic pregnancy rate

1.60 (9/562)

2.73 (8/293)

 

3.22 (3/93)

1.56 (1/64)

 

 Simultaneous intrauterine and extrauterine pregnancy

0.36 (2/562)

0.68 (2/293)

 

0

0

 
  1. Data are presented as percentage. IQR Interquartile range, EFPL Early follicular prolonged GnRH agonist, GnRH-Ant GnRH antagonist
  2. Chi-square test was used for comparison of clinical outcomes between the two groups. The variables in PSM model included female age, BMI, duration of infertility, type of infertility, basal sex hormone (E2, P, FSH, LH), AMH, insemination methods, the number of good quality embryos transferred and the type of embryos transferred. A 1:1 nearest neighbor matching method with caliper 0.1 was used to match data between the two groups