Table 2 Comparison of key newborn complication outcomes for the five selected antidepressants comparing exposure throughout pregnancy to no exposure in certain trimesters

Bupropion

Adaptation syndrome

Reference

1.24 (0.28–5.41)

1.31 (0.33–5.16)

1.78 (0.32–10.08)

NICU admission

Reference

0.43 (0.21–0.91)^a

0.75 (0.37–1.49)

0.49 (0.19–1.23)

Citalopram

Adaptation syndrome

Reference

0.79 (0.22–2.90)

2.54 (0.77–8.30)

0.87 (0.14–5.28)

NICU admission

Reference

0.97 (0.44–2.14)

1.09 (0.52–2.32)

1.06 (0.33–3.37)

Escitalopram

Adaptation syndrome

Reference

0.19 (0.07–0.48)^a

0.54 (0.25–1.18)

0.12 (0.02–0.97)

NICU admission

Reference

0.49 (0.28–0.85)^a

0.59 (0.35–1.02)

0.45 (0.20–1.01)

Fluoxetine

Adaptation syndrome

Reference

0.54 (0.16–1.87)

0.97 (0.35–2.69)

0.24 (0.03–2.10)

NICU admission

Reference

1.11 (0.62–2.00)

1.57 (0.89–2.78)

1.62 (0.78–3.37)

Sertraline

Adaptation syndrome

Reference

0.53 (0.25–1.11)

0.92 (0.48–1.74)

0.45 (0.16–1.22)

NICU admission

Reference

0.96 (0.69–1.37)

1.06 (0.75–1.49)

0.85 (0.54–1.34)