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Table 2 Ovarian stimulation characteristics of two treatment protocols

From: Comparison of pregnancy outcomes between GnRH antagonist protocol with freeze-all strategy and long-acting GnRH agonist protocol in women with adenomyosis undergoing IVF/ICSI: a propensity-score matching analysis

 

Original cohort

P

PSM cohort

P

Group A (n = 168)

Group B (n = 114)

Group A (n = 71)

Group B (n = 71)

Gonadotropin dosage (IU)

2639.36 ± 741.08

2697.37 ± 968.87

0.570

2406.69 ± 564.97

2930.28 ± 1040.40

0.001

Duration of stimulation (days)

9.77 ± 1.63

11.84 ± 2.98

< 0.001

9.49 ± 1.29

11.93 ± 3.05

< 0.001

Number of oocytes retrieved (n)

7.00 (4.00–10.00)

10.00 (7.00–12.75)

< 0.001

8.00 (6.00–12.50)

9.00 (6.00–12.00)

0.978

Fertilization type (n, %)

  

0.162

  

0.431

IVF

144 (85.71%)

88 (77.19%)

 

62 (87.32%)

57 (80.28%)

 

ICSI

19 (11.31%)

22 (19.30%)

 

8 (11.27%)

11 (15.49%)

 

IVF + ICSI

5 (2.98%)

4 (3.51%)

 

1 (1.41%)

3 (4.23%)

 

Number of fertilization (n)

6.00 (4.00–8.00)

8.00 (5.00–10.00)

0.001

7.00 (5.00–10.50)

7.00 (5.00–10.00)

0.606

2PN(n)

4.00 (3.00–7.00)

6.00 (4.00–8.00)

0.002

6.00 (4.00–7.50)

5.00 (4.00–8.00)

0.766

Number of available embryos (n)

4.00 (3.00–6.00)

5.00 (3.00–7.00)

0.011

5.00 (3.00–700)

5.00 (2.50–700)

0.818

Number of high-quality embryos (n)

2.00 (1.00–4.00)

3.00 (2.00–5.00)

0.080

3.00 (2.00–5.00)

3.00 (2.00–5.00)

0.461

Number of transferred embryos (n, %)

  

0.420

  

0.263

1

96 (57.14%)

68 (59.65%)

 

49 (69.01%)

41 (57.75%)

 

2

72 (42.86%)

45 (39.47%)

 

22 (30.99%)

29 (40.85%)

 

3

0 (0.00%)

1 (0.88%)

 

0 (0.00%)

1 (1.41%)

 

Number of transferred high-quality embryos (n, %)

  

0.007

  

0.009

0

69(41.07%)

39(34.21%)

 

30(42.25%)

24(33.80%)

 

1

91(54.17%)

57(50.00%)

 

40(56.34%)

33(46.68%)

 

2

8(4.76%)

18(15.79%)

 

1(1.41%)

14(19.72%)

 

Embryo stage (n, %)

  

0.002

  

>0.99

Cleavage stage

99 (58.93%)

46 (40.35%)

 

32 (45.07%)

33 (46.48%)

 

Blastocyst stage

69 (41.07%)

68 (59.65%)

 

39 (54.93%)

38 (53.52%)

 
  1. Note: Group A = GnRH antagonist protocol and freeze-all strategy; Group B = long-acting GnRH agonist protocol; PSM = propensity-score matching; IVF = in vitro fertilization; ICSI = intracytoplasmic sperm injection; 2PN = two pronuclear