From: Insulin resistance in women with recurrent miscarriage: a systematic review and meta-analysis
 |  |  |  |  | Test for subgroup differences | ||
---|---|---|---|---|---|---|---|
Subgroup | No. of comparisons | MD (95%CI) | I2 (%) | P-value for heterogeneity | Chi2 | P | I2 (%) |
Region | |||||||
 Asia | 1 | -1.44 [-1.76, -1.12] |  |  | 2.48 | 0.29 | 19.2 |
 America | 1 | -1.90 [-4.32, 0.52] |  |  |  |  |  |
 Middle East | 3 | -4.47 [-8.32, -0.61] | 94 |  < 0.00001 |  |  |  |
Definition of RPL | |||||||
  >  = 2 | 3 | -5.70 [-10.98, -0.42] | 94 |  < 0.00001 | 3.28 | 0.07 | 69.5 |
  >  = 3 | 2 | -0.77 [-1.49, -0.05] | 0 | 0.50 |  |  |  |
Matched confounders | |||||||
 No | 1 | -1.44 [-1.76, -1.12] |  |  | 2.02 | 0.16 | 50.6 |
 Yes | 4 | -3.61 [-6.59, -0.64] | 92 |  < 0.00001 |  |  |  |
Measurement timing | |||||||
 During pregnancy | 1 | -1.44 [-1.76, -1.12] |  |  | 2.02 | 0.16 | 50.6 |
 Not during pregnancy | 4 | -3.61 [-6.59, -0.64] | 92 |  < 0.00001 |  |  |  |
Exclusion of known factors | |||||||
 Yes | 1 | -16.10 [-21.12, -11.08] |  |  | 33.14 |  < 0.00001 | 97.0 |
 No | 4 | -1.34 [-1.63, -1.04] | 12 | 0.33 |  |  |  |