From: Insulin resistance in women with recurrent miscarriage: a systematic review and meta-analysis
 |  |  |  |  | Test for subgroup differences | ||
---|---|---|---|---|---|---|---|
Subgroup | No. of comparisons | MD (95%CI) | I2 (%) | P-value for heterogeneity | Chi2 | P | I2 (%) |
Region | |||||||
 Asia | 5 | 0.43 [0.13, 0.73] | 91 |  < 0.00001 | 1.15 | 0.56 | 0 |
 Africa | 1 | 0.56 [-0.05, 1.17] |  |  |  |  |  |
 Middle East | 2 | 1.46 [-0.48, 3.40] | 81 | 0.02 |  |  |  |
Definition of RPL | |||||||
  >  = 2 | 7 | 0.51 [0.22, 0.81] | 89 |  < 0.00001 | 0.06 | 0.80 | 0 |
  >  = 3 | 1 | 0.60 [-0.02, 1.22] |  |  |  |  |  |
Matched confounders | |||||||
 No | 4 | 0.32 [0.04, 0.60] | 90 |  < 0.00001 | 3.96 | 0.05 | 74.8 |
 Yes | 4 | 0.92 [0.40, 1.43] | 56 | 0.08 |  |  |  |
Measurement timing | |||||||
 During pregnancy | 2 | 0.28 [-0.13, 0.70] | 74 | 0.05 | 1.72 | 0.19 | 41.8 |
 Not during pregnancy | 6 | 0.68 [0.26, 1.10] | 89 |  < 0.00001 |  |  |  |
Exclusion of known factors | |||||||
 Yes | 6 | 0.42 [0.21, 0.64] | 72 | 0.003 | 0.24 | 0.62 | 0 |
 No | 2 | 0.49 [0.31, 0.67] | 0 | 0.85 |  |  |  |