From: Insulin resistance in women with recurrent miscarriage: a systematic review and meta-analysis
 |  |  |  |  | Test for subgroup differences | ||
---|---|---|---|---|---|---|---|
Subgroup | No. of comparisons | MD (95%CI) | I2 (%) | P-value for heterogeneity | Chi2 | P | I2 (%) |
Region | |||||||
 Asia | 5 | 1.86 [0.52, 3.19] | 89 |  < 0.00001 | 4.08 | 0.40 | 2 |
 Africa | 2 | 7.92 [-4.78, 20.61] | 94 |  < 0.0001 |  |  |  |
 Europe | 2 | 1.20 [-1.18, 3.58] | 87 | 0.006 |  |  |  |
 America | 2 | 2.72 [1.13, 4.30] | 0 | 0.45 |  |  |  |
 Middle East | 5 | 5.93 [0.71, 11.16] | 97 |  < 0.00001 |  |  |  |
Definition of RPL | |||||||
  >  = 2 | 11 | 2.63 [1.43, 3.83] | 89 |  < 0.00001 | 0.81 | 0.37 | 0 |
  >  = 3 | 5 | 4.78 [0.25, 9.31] | 97 |  < 0.00001 |  |  |  |
Matched confounders | |||||||
 No | 8 | 1.02 [0.76, 1.27] | 97 |  < 0.00001 | 11.00 | 0.0009 | 90.9 |
 Yes | 8 | 2.33 [1.60, 3.05] | 55 | 0.03 |  |  |  |
Measurement timing | |||||||
 During pregnancy | 4 | 7.82 [1.00, 14.63] | 98 |  < 0.00001 | 2.55 | 0.11 | 60.8 |
 Not during pregnancy | 12 | 2.21 [1.25, 3.16] | 82 |  < 0.00001 |  |  |  |
Exclusion of known factors | |||||||
 Yes | 11 | 4.42 [2.45, 6.52] | 96 |  < 0.00001 | 5.25 | 0.02 | 81.0 |
 No | 5 | 1.75 [0.58, 2.91] | 60 | 0.04 |  |  |  |