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Table 1 Summary characteristics of the included studies for meta-analyses

From: Factors affecting low fetal fraction in fetal screening with cell-free DNA in pregnant women: a systematic review and meta-analysis

Study

Year

Country

Study type

Number of LFF

Number of SFF

Mean of GA (LFF)

SD (min–max) Of GA (LFF)

Mean of GA (SFF)

SD (min–max) Of GA (SFF)

Mean of Maternal Age (LFF)

SD (min–max) Of Maternal Age (LFF)

Burns W [12]

2017

USA

Retrospective cohort

18

2875

14.3

(-, -) 3.78

13.4

(-, -) 3.33

37.3

5.90

Dabi Y [13]

2018

France

Prospective cohort

58

295

12.6

(27.5- 11.1)

-

(-, -) -

34

(35.7–40.1)

Krishna I [14]

2016

USA

Retrospective cohort

22

348

16.4

(-, -) 4.2

17

(-, -) 5.5

35

(22–46)

Miltoft CB [15]

2019

Denmark

Prospective cohort

10

321

-

(-, -) -

-

(-, -) -

33.3

4.2

Nakamura N [16]

2020

Japan

Retrospective cohort

23

2628

12.1

(14.7– 10.0) 1.3

12.7

(18.4 – 10.0) 1.6

38.6

2(34.8–43.4)

Wang E [3]

2013

USA

Prospective cohort

357

22384

13.9

(-, -) 4.55

15.79

(-, -) 4.55

-

-

Zhao Q [17]

2019

China

Prospective cohort

42

2202

14.43

(-, -) 4.20

16.95 / 16.57

(26 – 12) 2.89

-

-

Study

Mean of Maternal Age (SFF)

SD (min–max) Of Maternal Age (SFF)

Mean of BMI (LFF)

SD (min–max) of BMI (LFF)

Mean of BMI (SFF)

SD (min–max) of BMI (SFF)

Mean of Maternal Weight (LFF)

SD (min–max) of Maternal Weight (LFF)

Mean of MW (SFF)

SD (min–max) of Maternal Weight (SFF)

Burns W [12]

39.2

11.6

34.6

(-, -) 8.90

26.4

(-, -) 6.25

-

(-, -) -

-

(-, -) -

Dabi Y [13]

34

(29.6–37.1)

29

(32.9 – 22.3) -

23.7

(25.9—20.7) -

77

(90.3 -60) -

64

(70—56) -

Krishna I [14]

35

(14–46)

36.5

(54.6- 22.9) -

29.1

(54.9 – 17.3) -

-

(-, -) -

-

(-, -) -

Miltoft CB [15]

32.7

4.2

19.5

(24.2 –20.3) -

21.8

(24.2 – 20.3) -

-

(-, -) -

-

(-, -) -

Nakamura N [16]

39

2.6(24.8–49.1)

20.9

(29.1 – 15.7) 2.8

20.8

(34.8 – 14.5) 2.6

-

(-, -) -

-

(-, -) -

Wang E [3]

-

-

-

(-, -) -

-

(-, -) -

103

(-284 32) -

73

(-, -) 8.66

Zhao Q [17]

 

-

23.1/23.7

(39.7 – 15.6) 3.6

23.1

(-, -) 3.58

-

(-, -) -

-

(-, -) -

  1. LFF Low Fetal Fraction, SFF Sufficient Fetal Fraction, GA Gestational Age, MA Maternal Age, MW Maternal Weight, BMI Body Mass Index, SD Standard Deviation