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Table 3 Interaction model of total volume postpartum blood loss by OXTR rs53576 and intrapartum oxytocin dosage, using a gamma distribution

From: Oxytocin receptor single nucleotide polymorphism predicts atony-related postpartum hemorrhage

 

Model 1: Unadjusted β(95%CI)

Model 2: Adjusted β(95% CI)

Model 3: Adjusted β(95%CI)

Model 4: Adjusted β(95%CI)

Main effects

AG/AA without oxytocin use

347.19 (174.25 – 520.13)***

390.07 mL (216.49 – 563.65)***

373.54 mL (193.02 – 554.07)***

371.39 mL (196.61 – 546.18)***

GG with intrapartum oxytocin (per Unit)

39.70 (11.72 – 67.68)**

41.22 mL (14.19 – 68.25)**

38.51 mL (11.31 – 65.71)**

38.17 mL (10.77 – 65.56)**

Interaction

OXTR AG/AA (vs. GG) x per oxytocin Unit

-36.87 (-69.48 – 4.26)*

-40.63 mL (-72.30 – -8.96)*

-39.86 mL (-71.71 – -8.02)*

-40.56 mL (-72.35 – -8.56)*

  1. Model 2: adjusted for self-reported European ancestry
  2. Model 3: adjusted for self-reported European ancestry, primiparity
  3. Model 4: adjusted for self-reported European ancestry, primiparity, genital lacerations
  4. * < 0.05, ** < 0.01, *** < 0.001