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Table 4 Multivariate logistic regression analysis of the association between isolated maternal hypothyroxinemia in the first trimester and adverse pregnancy outcomes

From: Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases

Adverse pregnancy outcomes

Unadjusted model

OR (95% CI)

P

Adjusted model1

0R (95% CI)

P

Mother

 GDM

1.462(1.267–1.687)

 < 0.001

1.126(0.947–1.337) a

0.179

 Premature delivery

  < 37 weeks

0.979(0.731–1.310)

0.886

0.751(0.533–1.058) b

0.101

  < 34 weeks

1.515(0.882–2.602)

0.132

1.170(0.613–2.233) b

0.634

 Gestational hypertension

0.894(0.600–1.331)

0.581

0.639(0.407–1.003) a

0.051

 Preeclampsia

1.233(0.756–2.010)

0.402

0.740(0.415–1.322) a

0.310

 Placenta previa

1.412(0.887–2.249)

0.146

1.242(0.724–2.131) a

0.432

 Placental abruption

1.104(0.635–1.919)

0.725

0.612(0.385–0.973) c

0.038

 PROM

0.998(0.864–1.152)

0.974

0.971(0.822–1.147) b

0.730

 IUGR

0.582(0.332–1.021)

0.059

0.709(0.389–1.293) c

0.262

 Oligohydramnios

0.720(0.558–0.928)

0.011

0.781(0.586–1.041) c

0.092

Polyhydramnios

1.412(0.887–2.249)

0.146

1.128(0.646–1.969) c

0.672

 Stillbirth

1.018(0.383–2.704)

0.972

0.742(0.254–2.168) b

0.586

 PPH

1.319(1.046–1.664)

0.019

1.289(0.983–1.690) d

0.067

Newborn

 Macrosomia

1.660(1.188–2.320)

0.003

1.457(1.000–2.176)e

0.050

 SGA

0.869(0.655–1.152)

0.329

0.927(0.669–1.283) e

0.646

 LGA

1.497(1.268–1.768)

 < 0.001

1.270(1.044–1.566) e

0.017

 Low Apgar score (≤ 7 at 1 or 5 min)

1.207(0.732–1.989)

0.461

1.207(0.682–2.137) d

0.519

  1. BMI body mass index, GDM Gestational diabetes mellitus, PPH postpartum haemorrhage, LGA large for gestational age, FPG fasting plasma glucose, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol
  2. aAdjusted for maternal age, preBMI, gravity, parity, education level, FPG, TG, TC, HDL-C and LDL-C
  3. bAdjusted for maternal age, preBMI, gravity, parity, education level, FPG, TG, TC, HDL-C, LDL-C, GDM, gestational hypertension, preeclampsia, placenta previa, placental abruption, polyhydramnios and oligohydramnios
  4. cAdjusted for maternal age, preBMI, gravity, parity, education level, FPG, TG, TC, HDL-C, LDL-C, GDM, PROM, gestational hypertension and preeclampsia
  5. dAdjusted for maternal age, preBMI, gravity, parity, education level, FPG, TG, TC, HDL-C, LDL-C, GDM, gestational hypertension, preeclampsia, placenta previa, placental abruption, polyhydramnios and delivery mode
  6. eAdjusted for maternal age, preBMI, gravity, parity, education level, gestational age, FPG, TG, TC, HDL-C, LDL-C, GDM, and newborn sex