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Table 3 Comparison of adverse pregnancy outcomes between pregnant women with IMH and euthyroid women in the first trimester

From: Association between isolated maternal hypothyroxinemia during the first trimester and adverse pregnancy outcomes in Southern Chinese women: a retrospective study of 7051 cases

Adverse pregnancy outcomes

Euthyroid (n = 5714)

IMH (n = 1337)

χ2

P

Mother

 GDM (%)

1005(17.6)

318(23.8)

27.291

 < 0.001

 Premature delivery

  < 37 weeks

253(4.4)

58(4.3)

0.021

0.886

  < 34 weeks

51(0.9)

18(1.3)

2.302

0.129

 Gestational hypertension

143(2.5)

30(2.2)

0.304

0.581

 Preeclampsia

73(1.3)

21(1.6)

0.705

0.401

 Placenta previa

73(1.3)

24(1.8)

2.139

0.144

 Placental abruption

62(1.1)

16(1.2)

0.123

0.725

 PROM

1246(21.8)

291(21.8)

0.001

0.974

 IUGR

102(1.8)

14(1.0)

3.647

0.056

Polyhydramnios

73(1.3)

24(1.8)

2.139

0.144

 Oligohydramnios

430(7.5)

74(5.5)

6.469

0.011

 Stillbirth

21(0.4)

5(0.4)

0.001

0.972

 PPH

330(5.8)

100(7.5)

5.495

0.019

Newborn

 Macrosomia

128(2.2)

49(3.7)

8.988

0.003

 SGA

298(5.2)

61(4.8)

0.956

0.328

 LGA

661(11.6)

219(16.4)

22.967

 < 0.001

 Low Apgar score (≤ 7 at 1 or 5 min)

71(1.2)

20(1.5)

0.779

0.677

  1. IMH isolated maternal hypothyroxinemia, GDM gestational diabetes mellitus, PROM premature rupture of membranes, IUGR intrauterine growth restriction, PPH postpartum haemorrhage, SGA small for gestational age, LGA large for gestational age