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Table 2 Clinical characteristics and pregnancy outcome of IVF-PE and NC-PE group

From: Pregnancy outcomes and risk factors for preeclampsia in dichorionic twin pregnancies after in vitro fertilization: a five-year retrospective study

 

IVF-PE group (n = 117)

NC-PE group (n = 64)

P value

Gestational age at delivery (weeks)

35.27 ± 2.05

35.21 ± 2.24

0.853

Gestational age at diagnosis (weeks)

32.68 ± 2.64

33.76 ± 2.58

0.009

Hospitalization time (days)

9.44 ± 5.57

8.94 ± 3.71

0.474

Maximum systolic BP, mmHg

163.17 ± 12.06

163.63 ± 10.24

0.799

Maximum diastolic BP, mmHg

102.99 ± 7.74

101.64 ± 6.69

0.241

Systolic BP ≥ 180 mmHg n (%)

12 (10.2)

6 (9.4)

0.850

Diastolic BP ≥ 120 mmHg n (%)

3 (2.6)

0 (0)

0.495

24-hour urine protein (g)

2.53 ± 3.40

2.09 ± 2.44

0.354

Severe PE n (%)

97 (82.9)

48 (75.0)

0.203

Early-onset PE n (%)

92 (78.6)

28 (43.8)

< 0.001

Pleural effusion and (or) ascites n (%)

22 (18.8)

10 (15.6)

0.592

Liver or (and) renal insufficiency n (%)

14 (12.0)

8 (12.5)

0.916

Thrombocytopenia n (%)

10 (8.5)

4 (6.3)

0.793

Placental abruption n (%)

10 (8.5)

2 (3.1)

0.276

HELLP syndrome n (%)

8 (6.8)

2 (3.1)

0.481

Eclampsia or Cardiac failure n (%)

5 (4.3)

3 (4.7)

1.000

Maternal complications

 Gestational diabetes mellitus n (%)

28 (23.9)

14 (21.9)

0.754

 Ggestationa hypothyroidism n (%)

13 (11.1)

6 (9.4)

0.716

 Intrahepatic cholestasis during pregnancy n (%)

13 (11.1)

7 (10.9)

0.972

 Postpartum hemorrhage n (%)

20 (17.1)

6 (9.4)

0.157

 Oligohydramnios n (%)

5 (4.3)

4 (6.3)

0.820

 Growth discordance in twins n (%)

13 (11.1)

16 (25.0)

0.015

 Intrauterine growth retardation n (%)

35 (29.9)

24 (37.5)

0.298

Perinatal outcome

 Birth weight (g)

2266.26 ± 498.66

2212.97 ± 499.93

0.493

 Caesarean section n (%)

113 (96.6)

60 (93.8)

0.612

 Preterm delivery n (%)

64 (54.7)

35 (54.7)

0.999

 Very preterm delivery(< 34 weeks) n (%)

25 (21.4)

14 (21.9)

0.937

 Very low birth weight n (%)

11 (9.4)

8 (12.5)

0.516

 Neonatal asphyxia n (%)

64 (54.7)

38 (59.4)

0.544

  1. All data are presented as the mean ± standard deviation or n (%)
  2. Abbreviations: IVF In vitro fertilization, NC Natural conception, PE Preeclampsia, BP Blood pressure, HELLP Syndrome hemolysis, elevated liver enzymes, and low platelet count