Outcomes | Experimental studies1(n = 38) | Observa-tional studies2(n = 12) | Qualitative studies(n = 1) | All study designs(n = 51) | ||||
---|---|---|---|---|---|---|---|---|
Maternal outcomes | ||||||||
Labour pain | ||||||||
  - Pain score | 35 | (92.1) | 5 | (41.7) | 0 | (0.0) | 40 | (78.4) |
Maternal assessment | ||||||||
  - Blood pressure | 28 | (73.7) | 4 | (33.3) | 0 | (0.0) | 32 | (62.7) |
  - Maternal Heart Rate | 19 | (23.7) | 4 | (33.3) | 0 | (0.0) | 23 | (45.1) |
  - Respiratory Rate | 17 | (44.7) | 3 | (25.0) | 0 | (0.0) | 20 | (39.2) |
  - Motor block | 15 | (39.5) | 1 | (8.3) | 0 | (0.0) | 16 | (31.4) |
  - SPO2 | 9 | (23.7) | 3 | (25.0) | 0 | (0.0) | 12 | (23.5) |
  - Sensory level | 10 | (26.3) | 0 | (0.0) | 0 | (0.0) | 10 | (19.6) |
  - Vital signs | 2 | (5.3) | 0 | (0.0) | 0 | (0.0) | 2 | (3.9) |
  - Fever | 1 | (2.6) | 0 | (0.0) | 0 | (0.0) | 1 | (2.0) |
Delivery outcomes | ||||||||
  - Mode of delivery | 20 | (52.6) | 9 | (75.0) | 0 | (0.0) | 29 | (56.9) |
  - Duration of labour | 16 | (42.1) | 5 | (41.7) | 0 | (0.0) | 21 | (41.2) |
  - Induction of labour | 7 | (18.4) | 8 | (66.7) | 0 | (0.0) | 15 | (29.4) |
  - Duration/Frequency of contraction | 7 | (18.4) | 1 | (8.3) | 0 | (0.0) | 8 | (15.7) |
  - Duration of postpartum hospital stay | 1 | (2.6) | 3 | (25.0) | 0 | (0.0) | 4 | (7.8) |
Analgesia | ||||||||
  - Duration of analgesia | 19 | (23.7) | 4 | (33.3) | 0 | (0.0) | 23 | (45.1) |
  - Plasma/CSF fentanyl concentration | 6 | (15.8) | 2 | (16.7) | 0 | (0.0) | 8 | (15.7) |
  - Request for additional analgesia | 5 | (13.2) | 1 | (8.3) | 0 | (0.0) | 6 | (11.8) |
  - Time to request additional analgesia | 4 | (10.5) | 0 | (0.0) | 0 | (0.0) | 4 | (7.8) |
Adverse effects | ||||||||
  - Nausea | 25 | (65.8) | 3 | (25.0) | 0 | (0.0) | 28 | (54.9) |
  - Vomiting | 25 | (65.8) | 3 | (25.0) | 0 | (0.0) | 28 | (54.9) |
  - Pruritus | 25 | (65.8) | 1 | (8.3) | 0 | (0.0) | 26 | (51.0) |
  - Sedation | 21 | (55.3) | 3 | (25.0) | 0 | (0.0) | 24 | (47.1) |
  - Headache | 5 | (13.2) | 0 | (0.0) | 0 | (0.0) | 5 | (9.8) |
  - Shivering | 4 | (10.5) | 0 | (0.0) | 0 | (0.0) | 4 | (7.8) |
  - Neurological symptoms (numbness, leg weakness) | 4 | (10.5) | 0 | (0.0) | 0 | (0.0) | 4 | (7.8) |
  - Subjective maternal adverse effects | 2 | (5.3) | 0 | (0.0) | 0 | (0.0) | 2 | (3.9) |
  - Nasal irritation | 1 | (2.6) | 0 | (0.0) | 0 | (0.0) | 1 | (2.0) |
  - Post-partum haemorrhage | 0 | (0.0) | 1 | (8.3) | 0 | (0.0) | 1 | (2.0) |
  - Use of bag mask ventilation | 0 | (0.0) | 1 | (8.3) | 0 | (0.0) | 1 | (2.0) |
  - Maternal intubation | 0 | (0.0) | 1 | (8.3) | 0 | (0.0) | 1 | (2.0) |
  - Maternal naloxone | 0 | (0.0) | 1 | (8.3) | 0 | (0.0) | 1 | (2.0) |
  - Maternal SpO2 < 90 | 0 | (0.0) | 1 | (8.3) | 0 | (0.0) | 1 | (2.0) |
Maternal stress | ||||||||
  - Norepinephrine and Epinephrine concentration in maternal blood | 1 | (2.6) | 0 | (0.0) | 0 | (0.0) | 1 | (2.0) |
Breastfeeding status/problems | ||||||||
  - Breastfeeding status/problems | 2 | (5.3) | 4 | (33.3) | 1 | (100) | 7 | (13.7) |
Satisfaction | ||||||||
  - Satisfaction on pain relief | 7 | (18.4) | 1 | (8.3) | 1 | (100) | 9 | (17.6) |
Neonatal outcomes | ||||||||
  - Foetal Heart Rate | 31 | (81.6) | 2 | (16.7) | 0 | (0.0) | 33 | (64.7) |
  - Apgar score | 23 | (60.5) | 9 | (75.0) | 0 | (0.0) | 32 | (62.7) |
  - Cord blood gases | 14 | (36.8) | 5 | (41.7) | 0 | (0.0) | 19 | (37.3) |
  - Birthweight | 9 | (23.7) | 7 | (58.3) | 0 | (0.0) | 16 | (31.4) |
  - Naloxone requirement | 9 | (23.7) | 5 | (41.7) | 0 | (0.0) | 14 | (27.5) |
  - Neurologic & Adaptive Capacity Score | 10 | (26.3) | 0 | (0.0) | 0 | (0.0) | 10 | (19.6) |
  - Resuscitation efforts | 4 | (10.5) | 4 | (33.3) | 0 | (0.0) | 8 | (15.7) |
  - NICU/Nursery admission | 1 | (2.6) | 4 | (33.3) | 0 | (0.0) | 5 | (9.8) |
  - Neonatal fever | 2 | (5.3) | 1 | (8.3) | 0 | (0.0) | 3 | (5.9) |
  - Neonatal SPO2 | 3 | (7.9) | 0 | (0.0) | 0 | (0.0) | 3 | (5.9) |
  - Time to establish breathing | 1 | (2.6) | 2 | (16.7) | 0 | (0.0) | 3 | (5.9) |
  - Congenital anomalies | 1 | (2.6) | 1 | (8.3) | 0 | (0.0) | 2 | (3.9) |
  - Fetal body movement | 2 | (5.3) | 0 | (0.0) | 0 | (0.0) | 2 | (3.9) |
  - Requirement of CPAP | 1 | (2.6) | 1 | (8.3) | 0 | (0.0) | 2 | (3.9) |
  - Skin cyanosis | 1 | (2.6) | 0 | (0.0) | 0 | (0.0) | 1 | (2.0) |
  - Requirement of Epinephrine | 0 | (0.0) | 1 | (8.3) | 0 | (0.0) | 1 | (2.0) |