From: Effect of low dose aspirin application during pregnancy on fetal congenital anomalies
LDA group (n = 1,684) | Control group (n = 1,079) | P value | |
---|---|---|---|
Fetal congenital abnormalities, n (%) | 56 (3.33) | 30 (2.78) | 0.421 |
Anencephaly Q00, n (%) | 0 | 0 | NA |
Spina bifida Q05, n (%) | 0 | 0 | NA |
Encephalocele Q01, n (%) | 2 (0.12) | 0 | 0.524 |
Congenital hydrocephalus Q03, n (%) | 0 | 0 | NA |
Cleft palate Q35, n (%) | 2 (0.12) | 0 | 0.524 |
Cleft lip Q36, n (%) | 1 (0.06) | 1 (0.09) | 1 |
Cleft lip with cleft palate Q37, n (%) | 2 (0.12) | 0 | 0.524 |
Small ears (including earless) Q17.2, Q16.0, n (%) | 1 (0.06) | 0 | 1 |
Other abnormalities of the external ear Q17, n (%) | 4 (0.24) | 0 | 0.276 |
Esophagus atresia or stenosis Q39, n (%) | 0 | 0 | NA |
Rectal and anal atresia or stenosis (including anus) Q42, n (%) | 3 (0.18) | 0 | 0.427 |
Hypospadias Q54, n (%) | 1 (0.06) | 1 (0.09) | 1 |
Bladder exstrophy Q64.1, n (%) | 0 | 0 | NA |
Clubfoot Q66.0, n (%) | 1 (0.06) | 2 (0.19) | 0.697 |
Polydactyly Q69, n (%) | 5 (0.30) | 2 (0.19) | 0.856 |
Syndactyly Q70, n (%) | 3 (0.18) | 1 (0.09) | 0.949 |
Shortened limbs (including ectrodactyly and cleft hand/foot) | |||
Upper limb Q71, n (%) | 0 | 1 (0.09) | 0.391 |
Lower limb Q72, n (%) | 0 | 0 | NA |
Congenital diaphragmatic hernia Q79.0, n (%) | 1 (0.06) | 0 | 1 |
Omphalocele Q79.2, n (%) | 1 (0.06) | 0 | 1 |
Gastroschisis Q79.3, n (%) | 1 (0.06) | 1 (0.09) | 1 |
Conjoined twin Q89.4, n (%) | 0 | 0 | 0 |
Down syndrome (trisomy 21) Q90, n (%) | 0 | 0 | 0 |
Congenital heart diseases Q20-26, n (%) | 19 (1.13) | 13 (1.20) | 0.854 |
Others, n (%) | 12 (0.71) | 8 (0.74) | 0.930 |