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Table 2 Comparison of fetal congenital abnormalities between the two groups

From: Effect of low dose aspirin application during pregnancy on fetal congenital anomalies

 

LDA group (n = 1,684)

Control group (n = 1,079)

P value

Fetal congenital abnormalities, n (%)

56 (3.33)

30 (2.78)

0.421

Anencephaly Q00, n (%)

0

0

NA

Spina bifida Q05, n (%)

0

0

NA

Encephalocele Q01, n (%)

2 (0.12)

0

0.524

Congenital hydrocephalus Q03, n (%)

0

0

NA

Cleft palate Q35, n (%)

2 (0.12)

0

0.524

Cleft lip Q36, n (%)

1 (0.06)

1 (0.09)

1

Cleft lip with cleft palate Q37, n (%)

2 (0.12)

0

0.524

Small ears (including earless) Q17.2, Q16.0, n (%)

1 (0.06)

0

1

Other abnormalities of the external ear Q17, n (%)

4 (0.24)

0

0.276

Esophagus atresia or stenosis Q39, n (%)

0

0

NA

Rectal and anal atresia or stenosis (including anus) Q42, n (%)

3 (0.18)

0

0.427

Hypospadias Q54, n (%)

1 (0.06)

1 (0.09)

1

Bladder exstrophy Q64.1, n (%)

0

0

NA

Clubfoot Q66.0, n (%)

1 (0.06)

2 (0.19)

0.697

Polydactyly Q69, n (%)

5 (0.30)

2 (0.19)

0.856

Syndactyly Q70, n (%)

3 (0.18)

1 (0.09)

0.949

Shortened limbs (including ectrodactyly and cleft hand/foot)

  Upper limb Q71, n (%)

0

1 (0.09)

0.391

  Lower limb Q72, n (%)

0

0

NA

Congenital diaphragmatic hernia Q79.0, n (%)

1 (0.06)

0

1

Omphalocele Q79.2, n (%)

1 (0.06)

0

1

Gastroschisis Q79.3, n (%)

1 (0.06)

1 (0.09)

1

Conjoined twin Q89.4, n (%)

0

0

0

Down syndrome (trisomy 21) Q90, n (%)

0

0

0

Congenital heart diseases Q20-26, n (%)

19 (1.13)

13 (1.20)

0.854

Others, n (%)

12 (0.71)

8 (0.74)

0.930

  1. Abbreviations: LDA low dose aspirin, NA not available
  2. Note: If a fetus had multiple malformations, he/she was included into different categories separately