Investigation of the role of X chromosome inactivation and androgen receptor CAG repeat polymorphisms in patients with recurrent pregnancy loss: a prospective case–control study

Table 2 Logistic regression models

Variables	P-value	Adjusted OR/RR^a	95%CI
Characteristics in relation to RPL*
CAG < 20	0.000	3.012	1.648–5.504
SXCI	0.002	63.064	4.381-907.785
Duration of stimulation	0.022	0.866	0.798–0.983
Characteristics in relation to DOR**
RPL group (participants in the case–control study, N = 131)
Age	0.000	1.891	1.341–2.665
AMH	0.001	0.214	0.090–0.511
Control group (N = 126)
CAG < 20	0.039	15.384	1.148-204.904
Age	0.005	1.622	1.154–2.280
AMH	0.001	0.026	0.003–0.210
RPL cohort (participants in the external validation cohort, N = 363)
Age	0.001	1.295	1.116–1.502
AMH	0.000	0.104	0.045–0.237
AFC	0.036	0.905	0.824–0.993
Characteristics in relation to blastocyst euploidy in patients with RPL***
RPL group (participants in the case–control study, N = 131)
AFC	0.000	1.336	1.164–1.532
RPL cohort (participants in the external validation cohort, N = 363)
Age	0.003	0.916	0.864–0.970
AFC	0.000	1.189	1.122–1.261

^aConfounders are evaluated using multivariate logistic regression models (backward LR) and covariates are retained in the final adjusted model if they are significantly associated with the outcome parameters (p < 0.05)
*OR adjusted for age, AMH, BMI, short CAG allele, BAM and XWBM.
**RR adjusted for SXCI, CAG20, XWBM, age, AMH, AFC, and duration of stimulation
***RR adjusted for age, AFC, AMH, SXCI, CAG20, XWBM, BMI, number of pregnancies loss, and duration of stimulation
CI = confidence interval; OR = odds ratio; RR = risk ratio; RPL = recurrent pregnancy loss; SXCI = skewed X chromosome inactivation; XWBM = X-weighted biallelic mean; BMI = body mass index; AMH = anti-Müllerian hormone; AFC = antral follicle count

ISSN: 1471-2393