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Table 2 Changes in biomarkers according to the diet group, with or without gestational diabetes mellitus

From: Association of pre-pregnancy low-carbohydrate diet with maternal oral glucose tolerance test levels in gestational diabetes

 

LC/GDM (N = 20)

Con/GDM (N = 80)

Con/Healthy (N = 80)

p-value

Variable

 1st trimester of pregnancy

  Gestational weeks(wk)

11.98 ± 2.16

11.93 ± 1.96

12.41 ± 1.53

0.222

  FBG (mmol/L)

4.41 ± 0.43

4.50 ± 0.35

4.57 ± 0.33

0.165

  HbA1c (%) (mmol/mol)

5.14 ± 0.46 (33) a

5.32 ± 0.27 (35) b

5.19 ± 0.32 (33)

 < 0.05

 2nd trimester of pregnancy

  Gestational weeks(wk)

25.51 ± 1.11

25.28 ± 1.20

25.20 ± 1.00

0.539

  OGTT

   Fasting (mmol/L)

4.15 ± 0.45

4.19 ± 0.48

4.11 ± 0.33

0.411

   1 h (mmol/L)

10.4 ± 1.28a

9.75 ± 0.98b

7.15 ± 1.16c

 < 0.001

   2 h (mmol/L)

9.12 ± 0.98a

8.29 ± 1.06b

6.19 ± 1.01c

 < 0.001

  Abnormal values, type

   Fasting (≥ 5.1 mmol/L [92 mg/dL]) (n, %)

1 (5)

5 (6.25)

Reference

0.064

   1 h (≥ 10.0 mmol/L [180 mg/dL) (n, %)

14 (70)

43 (53.75) b

Reference

 < 0.001

   2 h (≥ 8.5 mmol/L [153 mg/dL) (n, %)

14 (70)

49 (61.25) b

Reference

 < 0.001

  Abnormal values, n (%)

   0

0(0)

0(0)

80(100)

 < 0.001

   ≧1(GDM)

20(100)a

80(100) b

0(0)

 < 0.001

   1

11(55)a

64(80) b

0(0)c

 < 0.001

   2

9(45)a

15(18.75) b

0(0)c

 < 0.001

   3

0(0)

1(1.25)

0(0)

0.556

 Higher-1 h-2 h (n, %)

8 (40)a

13 (16.25) b

0 (0)c

 < 0.001

 AUC [mmol/(L˙h)]

17.0 ± 1.13a

16.0 ± 0.92b

12.6 ± 1.85c

 < 0.001

 HbA1c (%) (mmol/mol)

4.90 ± 0.30 (30)

5.05 ± 0.35 (31) b

4.92 ± 0.26 (30)

 < 0.05

 GA (%)

12.31 ± 1.23a

13.8 ± 1.59

13.49 ± 1.34c

 < 0.001

 Insulin treatment, n (%)

   

 < 0.001

  Yes

2 (10) a

0 (0)

0 (0) c

 < 0.001

 Detectable urinary ketone bodies (n, % of participants)

  1st trimester of pregnancy

2 (10)

2 (2.5)

5 (6.25)

0.306

  2nd trimester of pregnancy

5 (25) a

1 (1.25)

1 (1.25)c

 < 0.001

  3rd trimester of pregnancy

1 (5)

1 (1.25)

6 (7.5)

0.158

  1. LC Low carbohydrate diet, GDM Gestational diabetes, Con Conventional diet, FBG Fasting blood glucose, HbA1c Glycated haemoglobin, OGTT Oral glucose tolerance test, AUC Area under the blood glucose curve, GA Glycated albumin
  2. aThe value for the LC/GDM group is significantly different from the value for the Con/GDM group (P < 0.05)
  3. bThe value for the Con/GDM group is significantly different from the value for the Con/Healthy group (P < 0.05)
  4. cThe value for the LC/GDM group is significantly different from the value for the Con/Healthy group (P < 0.05)