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Table 2 Association between GRS and serum 25(OH)D levels during T3 of pregnancy

From: Impact of maternal dietary carbohydrate intake and vitamin D-related genetic risk score on birth length: the Vitamin D Pregnant Mother (VDPM) cohort study

Variables N Log 25(OH)D (ng/mL)a Log 25(OH)D (ng/mL)a
β Mean (SE) P value β Mean (SE) P value
Vitamin D-GRS total score*
 ≤ 3 110 0.08 1.31 (0.02) 0.010 0.08 1.31 (0.02) 0.009
 ≥ 4 73   1.23 (0.02)   1.23 (0.02)
VDR-GRS score**
 < 2 102 0.04 1.30 (0.02) 0.241 0.03 1.29 (0.02) 0.334
 ≥ 2 79   1.26 (0.02)   1.26 (0.02)
Non-VDR GRS score***
 < 3 124 0.09 1.30. (0.02) 0.009 0.10 1.31 (0.02) 0.003
 ≥ 3 54   1.213 (0.03)   1.21 (0.03)
  1. Data are presented as mean and standard error [mean (SE)]
  2. 25(OH)D 25-hydroxyvitamin D, SE Standard error, VDR Vitamin D receptor, GRS Genetic risk score
  3. P values obtained from linear regression analysis with the crude model
  4. P values obtained from linear regression analysis adjusted for age, pre-pregnancy BMI, sun exposure status, vitamin D supplement and geographical status
  5. aThe analysis was performed on log-transformed variables
  6. *All six SNPs in genes are involved in the synthesis and metabolism of vitamin D
  7. **Two SNPs in VDR genes are included in the ‘VDR-GRS score’
  8. ***Four SNPs in the DHCR7, GC, CYP24A1 and CYP2R1 genes are included in the ‘Non-VDR GRS score’