Table 1 Description of the eight indicator variables for LCCA and the baseline characteristics of the 1,000 enrolled PE patients

1. Maternal delivery age

Maternal delivery age

16

46

32 (28,36)

30 (27,33)

< 0.001

[1, 2, 20]

2. Mean arterial pressure

Mean arterial pressure (MAP) (mmHg)

91

180

126.67 (116.67,137.33)

117.33 (110,126.67)

< 0.001

[1, 2, 20]

3. Drugs use

Beta blockers

1

0

0

4

59 (44.03)

218 (25.17)

< 0.001

[1, 2, 20]

Calcium antagonist

1

0

29 (21.64)

89 (10.28)

< 0.001

Dexamethasone

1

0

11 (8.21)

42 (4.85)

0.106

MgSO₄

1

0

30 (22.39)

77 (8.89)

< 0.001

4. Medical history

Body mass index (BMI) before pregnancy ≥ 25

1

0

0

12

63 (47.01)

329 (37.99)

0.046

[1, 2, 20, 25,26,27]

Prior preeclampsia

1

0

9 (6.72)

55 (6.35)

0.872

History of heart / kidney disease

1

0

2 (1.49)

7 (0.81)

0.435

Family history of hypertension

1

0

25 (18.66)

124 (14.32)

0.189

Number of abortions

1-3

0

0.201

 0

64 (47.76)

489 (56.47)

 1

49 (36.57)

248 (28.64)

 2

13 (9.70)

90 (10.39)

 ≥ 3

8 (5.97)

39 (4.5)

Number of births

1-3

0

0.177

 0

68 (50.75)

523 (60.39)

 1

54 (40.30)

286 (33.03)

 2

11 (8.21)

49 (5.66)

 ≥ 3

1 (0.75)

8 (0.92)

≥ 10 years from the previous birth

1

0

30 (22.39)

94 (10.85)

< 0.001

PE was diagnosed before 32 weeks of gestation

1

0

61 (45.52)

295 (34.06)

0.010

5. Adverse pregnancy outcome

Preterm birth

1

0

0

6

90 (67.16)

459 (53)

0.002

[1, 2, 20]

Postpartum hemorrhage

1

0

7 (5.22)

42 (4.85)

0.852

Pericardial or pleural effusion

1

0

15 (11.19)

23 (2.66)

< 0.001

Placental abruption

1

0

18 (13.43)

94 (10.85)

0.378

Low birth weight infants / fetal growth restriction

1

0

24 (17.91)

130 (15.01)

0.387

HELLP syndrome

1

0

20 (14.93)

50 (5.77)

< 0.001

6. Blood cell and coagulation test

Platelet count (< 100×10⁹/L)

1

0

0

5

12 (8.96)

53 (6.12)

0.215

[1, 2, 20, 27]

Neutrophil count (> 6.3×10⁹/L)

1

0

83 (61.94)

472 (54.50)

0.107

Monocyte count (> 0.6×10⁹/L or < 0.1×10⁹/L)

1

0

51 (38.06)

283 (32.68)

0.219

PT% (> 130% or < 70%)

1

0

57 (42.54)

311 (35.91)

0.139

INR (>1.15 or < 0.85)

1

0

26 (19.40)

150 (17.32)

0.556

7. Liver and renal function

AST (> 40 U/L)

1

0

0

9

29 (21.64)

128 (14.78)

0.042

[1, 2, 20, 27]

ALT (> 40 U/L)

1

0

13 (9.70)

69 (7.97)

0.496

ALB (< 30 g/L)

1

0

65 (48.51)

346 (39.95)

0.061

Proteinuria

1-4

0

0.308

 0

20 (14.93)

123 (14.22)

 1+

26 (19.40)

237 (27.40)

 2+

29 (21.64)

149 (17.23)

 3+

49 (36.57)

307 (35.49)

 4+

10 (7.46)

49 (5.66)

Serum creatinine (> 1.0 mg/dL)

1

0

11 (8.21)

49 (5.66)

0.247

Serum urea nitrogen (> 7.6 mmol/L)

1

0

9 (6.72)

45 (5.20)

0.469

8. Blood myocardial enzyme and electrolyte test

Serum creatine kinase (> 200 U/L)

1

0

0

4

14 (10.45)

69 (7.97)

0.333

[1, 2, 27]

Serum lactate dehydrogenase (> 250 U/L)

1

0

47 (35.07)

263 (30.37)

0.273

Serum potassium (> 5.5 mmol/L or < 3.5 mmol/L)

1

0

7 (5.22)

35 (4.04)

0.525

Serum calcium (< 2.11 mmol/L)

1

0

60 (44.78)

297 (34.30)

0.018