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Table 1 Demographic and clinical characteristics of the study participants

From: Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study

Characteristic

TPOAb-positive women with SCH (64 cases)

TPOAb-negative women with SCH (68 cases)

P value

General information

 Han ethnicity, n (%)

59 (92.2)

62 (91.2)

0.834

 Education background (postgraduate and above), n (%)

15 (23.4)

17 (25.0)

0.996

 Education background (undergraduate), n (%)

35 (54.7)

35 (51.5)

 Education background (college and below), n (%)

14 (21.9)

16 (23.5)

 Family income (over 4 × 105yuan/year), n (%)

20 (31.3)

17 (25.0)

0.736

 Family income (105to 4 × 105yuan/year), n (%)

36 (56.2)

45 (66.2)

 Family income (less than 105 yuan/year), n (%)

8 (12.5)

6 (8.8)

 First pregnancy, n (%)

36 (56.3)

38 (55.9)

0.966

 Thyroid disease history, n (%)

24 (37.5)

10 (14.7)

0.003

 Natural pregnancy, n (%)

62 (96.9)

64 (94.1)

0.681

 Smoking, n (%)

4 (6.3)

4 (5.9)

1.000

 Drinking, n (%)

4 (6.3)

2 (2.9)

0.430

Indicator in the first trimester

 Sickness, n (%)

21 (32.8)

32 (47.1)

0.095

 Animals exposure, n (%)

8 (12.5)

13 (19.1)

0.299

 Age (year), median (IQR)

33 (30–36)

33 (31–34)

0.913

 BMI (kg/m2), median (IQR)

21.8 (20.2–24.6)

22.0 (19.9–25.2)

0.956

 SBP (mmHg), mean ± SD

112 ± 11

110 ± 10

0.171

 DBP (mmHg), median (IQR)

66 (58–74)

65 (57–70)

0.440

 ALT(U/L), median (IQR)

12.35 (9.73–21.50)

12.25 (10.03–18.15)

0.816

 AST(U/L), median (IQR)

14.45 (13.05–17.15)

15.40 (13.35–16.98)

0.347

 ALB(g/L), median (IQR)

43.80 (42.33–45.78)

43.85 (42.30–45.00)

0.437

 GLU (mmol/L), median (IQR)

4.64 (4.51–4.92)

4.67 (4.44–4.85)

0.537

 BUN (mmol/L), median (IQR)

2.97 (2.67–3.53)

3.05 (2.56–3.39)

0.375

 UA (μmol/L), median (IQR)

216.65 (187.25–257.63)

216.55 (187.53–254.28)

0.975

 CRE (μmol/L), mean ± SD

49.43 ± 6.64

48.53 ± 5.79

0.403

 TC (mmol/L), median (IQR)

4.34 (3.85–4.86)

3.98 (3.63–4.40)

0.009

 TG (mmol/L), median (IQR)

0.94 (0.67–1.40)

1.04 (0.74–1.49)

0.631

 HDL-C (mmol/L), median (IQR)

1.52 (1.33–1.75)

1.39 (1.23–1.57)

0.037

 LDL-C (mmol/L), median (IQR)

2.38 (1.93–2.86)

2.08 (1.82–2.48)

0.036

 HGB(g/L), median (IQR)

130 (120–138)

131 (123–136)

0.913

  1. Abbreviations: IQR Interquartile range, TPOAb Thyroid peroxidase antibody, BMI Body mass index, SBP Systolic blood pressure, DBP Diastolic blood pressure, ALT Alanine aminotransferase, AST Aspartic acid aminotransferase, ALB Albumin, GLU Blood glucose, BUN Blood urea nitrogen, UA Uric acid, CRE Creatinine, TC Total cholesterol, TG Triglycerides, HDL-C High-density lipoprotein-cholesterol, LDL-C Low-density lipoprotein-cholesterol, HGB Hemoglobin