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Table 3 Association of maternal lipid profile in early pregnancy with their corresponding offspring lipid level at the age of 6 and 10 years

From: Maternal lipid levels in early pregnancy as a predictor of childhood lipid levels: a prospective cohort study

Exposure

Lipids in pregnancy

Outcome

Lipid levels of children 6 years (n = 2692)

Basic model

Beta (95% CI)

Maternal BMI model

Beta (95% CI)

Maternal diet model

Beta (95% CI)

Total cholesterol, SDS

0.21 (0.16; 0.26)

0.21 (0.16; 0.26)

0.21 (0.16; 0.26)

Triglycerides, SDS

0.14 (0.09; 0.19)

0.14 (0.09; 0.20)

0.14 (0.09; 0.20)

LDL-c, SDS

0.19 (0.14; 0.25)

0.19 (0.14; 0.25)

0.19 (0.14; 0.25)

HDL-c, SDS

0.23 (0.18; 0.28)

0.23 (0.18; 0.28)

0.23 (0.18; 0.28)

Remnant cholesterol, SDS

0.14 (0.09; 0.19)

0.14 (0.09; 0.20)

0.14 (0.09; 0.20)

Non-HDL-c, SDS

0.19 (0.14; 0.24)

0.19 (0.14; 0.24)

0.19 (0.14; 0.24)

Lipids in pregnancy

Outcome

Lipid levels of children 10 years (n = 1673)

Basic model

Beta (95% CI)

Maternal BMI model

Beta (95% CI)

Maternal diet model

Beta (95% CI)

Total cholesterol, SDS

0.26 (0.21; 0.32)

0.26 (0.21; 0.32)

0.26 (0.21; 0.32)

Triglycerides, SDS

0.15 (0.10; 0.21)

0.14 (0.09; 0.20)

0.14 (0.09; 0.20)

LDL-c, SDS

0.26 (0.21; 0.31)

0.26 (0.21; 0.31)

0.26 (0.21; 0.31)

HDL-c, SDS

0.29 (0.24; 0.34)

0.28 (0.23; 0.33)

0.28 (0.23; 0.33)

Remnant cholesterol, SDS

0.16 (0.10; 0.21)

0.15 (0.09; 0.20)

0.15 (0.09; 0.20)

Non-HDL-c, SDS

0.25 (0.20; 0.30)

0.24 (0.19; 0.29)

0.24 (0.19; 0.29)

  1. Values are regression coefficients reflecting the difference in childhood lipid level with 95% confidence interval derived from multiple linear regression analyses. Basic model: adjusted for maternal age at intake, gestational age at blood sampling, ethnicity, parity, smoking and educational level. Maternal BMI model: basic model additionally adjusted for pre-pregnancy BMI. Maternal diet model: BMI model additionally adjusted for maternal diet
  2. Abbreviations: BMI Body mass index, CI Confidence interval, SDS SD-scores, LDL-c Low-density lipoprotein cholesterol, HDL-c High-density lipoprotein cholesterol