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Table 2 Univariate logistic regression analyses of different variables with EPL among first pregnancy patients in IVF cycles

From: Incidence and risk factors for early pregnancy loss in women with first pregnancy undergoing in vitro fertilization-embryo transfer

Variables

EPL n %

OR

95%CI

P

Female age, years

    

< 0.001

 < 35

289

13.5

1.00

  

 ≧35, < 40

92

18.5

1.46

1.13–1.89

0.004

 ≧40

30

42.3

4.69

2.88–7.64

< 0.001

Male age, years

    

< 0.001

 < 35

235

13.1

1.00

  

 ≧35, < 40

115

17.0

1.36

1.06–1.73

0.014

 ≧40

61

25.3

2.24

1.63–3.09

< 0.001

Female BMI, kg/m2

    

0.13

 ≧18.5, < 25

251

14.3

1.00

  

 < 18.5

35

14.3

1.00

0.68–1.47

1.00

 ≧25

125

17.5

1.27

1.00–1.60

0.049

AMH,μg/L

    

0.06

 ≥2

302

14.4

1.00

  

 ≥1.0, < 2

51

16.0

1.11

0.82–1.57

0.45

 < 1.0

37

13.3

1.56

1.07–2.29

0.022

Male smoking

    

0.42

 Never

275

14.8

1.00

  

 Smoking

131

15.7

1.07

0.85–1.34

0.58

 Smoked in the past

5

29.4

2.39

0.84–6.85

0.10

Cycle type

     

 Fresh

47

10.2

1.00

  

 Frozen-thaw

364

16.2

1.71

1.24–2.36

0.001

Adverse pregnancy history

     

 No

273

14.6

1.00

  

 Yes

138

16.3

1.13

0.91–1.42

0.26

Number of previous miscarriages

    

0.10

 0

294

14.6

1.00

  

 1

78

15.5

1.08

0.82–1.41

0.59

 2

27

19.6

1.43

0.92–2.21

0.11

 ≥3

12

25.0

1.96

1.01–3.81

0.048

IUI unfertilized history

     

 No

382

15.3

1.00

  

 Yes

29

13.6

0.87

0.58–1.31

0.51

IVF failed ET history

     

 No

388

15.1

1.00

  

 Yes

23

16.0

1.07

0.67–1.69

0.78

Female chromosome

    

0.98

 Normal

392

15.2

1.00

  

 Abnormal

18

14.9

0.98

0.56–1.63

0.93

 Not examed

1

16.7

1.12

0.13–9.59

0.92

Male chromosome

    

0.77

 Normal

385

15.3

1.00

  

 Abnormal

24

13.6

0.88

0.56–1.36

0.56

 Not examed

2

14.3

0.92

0.21–4.14

0.92

Embryo transfer stage

     

 Blastocyst

168

18.3

1.00

  

 Cleavage stage

243

13.6

0.70

0.57–0.87

0.001

Number of embryos transferred

     

 1

122

20.8

1.00

  

 ≥2

289

13.6

0.60

0.48–0.76

< 0.001

Thickness of endometrium, mma

     

 ≥ 7 or ≥ 8

393

14.9

1.00

  

 <  7 or < 8

18

24.3

1.84

1.07–3.17

0.027

Male factor

     

 No

189

15.2

1.00

  

 Yes

222

15.1

0.99

0.80–1.22

0.94

Tubal factor

     

 No

349

16.2

1.00

  

 Yes

62

11.2

0.65

0.49–0.87

0.004

Polycystic ovarian syndrome

     

 No

402

15.0

1.00

  

 Yes

9

25.7

1.96

0.91–4.21

0.09

Diminished ovarian reserve

     

 No

400

15.0

1.00

  

 Yes

11

28.9

2.31

1.14–4.70

0.020

Ovulatory dysfunction

     

 No

401

15.0

1.00

  

 Yes

10

26.3

1.77

0.86–3.62

0.12

Endometriosis

     

 No

407

15.1

1.00

  

 Yes

4

21.1

1.47

1.49–4.53

0.48

  1. EPL early pregnancy loss, IVF in vitro fertilization, OR odds ratio, CI confidence interval, BMI body mass index, AMH anti-Müllerian hormone, IUI intra-uterine insemination
  2. a For fresh IVF-ET cycles, thickness of endometrium was divided into two groups with a 8 mm boundary; for frozen-thaw -ET cycles, thickness of endometrium was divided into two groups with a 7 mm boundary
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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