Skip to main content

Table 2 Baseline characteristics for included studies

From: Maternal and neonatal safety outcomes after SAR-CoV-2 vaccination during pregnancy: a systematic review and meta-analysis

ID

study groups

sample size

Maternal Age, y, (Mean ± SD)

Pregravid BMI (kg/m2), (Mean ± SD)

Maternal comorbidities, N (%)

Gender, N (%)

Trimester at vaccination, n (%)

Hypertensive disorders

Diabetes or gestational diabetes

Asthma

Smoker

Male

Female

First

Second

Beharier 2021 [20]

Vaccinated group during pregnancy

92

31.7 ± 5.8

24.2 ± 5.2

1 (1.1)

8 (8.7)

2 (2.2)

6 (6.5)

45 (49.5)

46 (50.5)

  

Unvaccinated non infected controls

66

31.6 ± 5.8

25.7 ± 6.5

1 (1.5)

9 (13.6)

1 (1.5)

4 (6.6)

31 (47.7)

34 (52.3)

  

Blakeway 2021 [30]

At least 1 dose during pregnancy

140

34.33 ± 4.94

24.2 ± 4.4

13 (9.2)

  

1 (0.7)

  

0 (0.0)

20 (14.2)

Did not receive a vaccine during pregnancy

1188

33 ± 4.45

24.8 ± 4.8

46 (3.9)

  

27 (2.3)

    

Butt 2021 [31]

PCR positive

393

30.67 ± 5.21

         

PCR negative

862

31.33 ± 5.2

         

Collier 2021 [32]

Pregnant Vaccinated women

30

34.33 ± 3.11

       

5 (17%)

15 (50%)

Pregnant Unvaccinated and infected women

22

31.67 ± 6.34

         

Dagan 2021 [33]

Pregnant Vaccinated women

10,861

29.67 ± 5.19

 

40 (0.4%)

52 (0.5%)

372 (3.4%)

643 (5.9%)

  

2,814 (26%)

5,242 (48%)

Pregnant Unvaccinated and infected women

10,861

29.67 ± 5.19

 

34 (0.3%)

57 (0.5%)

388 (3.6%)

701 (6.5%)

    

Kharbanda 2021 [35]

Ongoing pregnancy periods (vaccinated women)

20,139

          

Spontaneous abortions (vaccinated women)

1128

          

Rottenstreich 2021 [36]

Covid‐19 vaccinated Pregnant women

712

30.6 ± 5.8

 

10 (1.4%)

45 (6.3%)

      

Covid‐19 Unvaccinated Pregnant women

1063

29.5 ± 6

 

19 (1.8%)

45 (4.2%)

      

Shanes 2021 [37]

Pregnant Vaccinated women

84

33.7 ± 3.1

         

Pregnant Unvaccinated women

116

32.5 ± 4.8

         

Theiler 2021 [38]

Covid‐19 vaccinated Pregnant women

140

31.8 ± 3.7

 

6 (4.3)

 

15 (10.7)

0

    

Covid‐19 Unvaccinated Pregnant women

1862

30.5 ± 5.2

 

64 (3.4)

 

206 (11.1)

196 (10.5)

    

Wainstock 2021 [39]

Covid‐19 vaccinated Pregnant women

913

30.6 ± 5.3

 

50 (5.5)

63 (6.9)

      

Covid‐19 Unvaccinated Pregnant women

3486

28.2 ± 5.7

 

165 (4.7)

187 (5.4)

      

Pfizer BioNTech C4591001

BNT162b2 (30 μg)

18,860

      

9639 (51.1)

9221 (48.9)

  

Placebo

18,846

      

9436 (50.1)

9410 (49.9)

  

Moderna mRNA-1273-P301

Moderna COVID-19 Vaccine mRNA-1273

15,208

          

Placebo

15,210

          

COV003 (Brazil)

ChAdOx1nCoV-19

3414

 

26.07 ± 4.45

 

141 (4.1%)

  

1478 (43.3)

1936 (56.7%)

  

MenACWY "control vaccine" (first dose), Saline (second dose)

3339

 

26.17 ± 4.6

 

113 (3.4%)

  

1500 (44.9)

1839 (55.1%)

  

ID

study groups

sample size

Maternal Age, y, (Mean ± SD)

Pregravid BMI (kg/m2), (Mean ± SD)

Trimester at vaccination, n (%)

Self-reported ethnicity, n (%)

Obesity (BMI ≥ 30 kg/m2), n (%)

   

Third

Caucasian

Afro-Caribbean

Asian

Mixed

Not reported

White

Other

Hispanic or Latina

Beharier 2021 [20]

Vaccinated group during pregnancy

92

31.7 ± 5.8

24.2 ± 5.2

          

Unvaccinated non infected controls

66

31.6 ± 5.8

25.7 ± 6.5

          

Blakeway 2021 [30]

At least 1 dose during pregnancy

140

34.33 ± 4.94

24.2 ± 4.4

121 (85.8)

80 (56.7)

18 (12.8)

5 (3.5)

13 (9.2)

25 (17.7)

   

15 (11.5)

Did not receive a vaccine during pregnancy

1188

33 ± 4.45

24.8 ± 4.8

 

551 (46.4)

204 (17.2)

101 (8.5)

156 (13.1)

175 (14.7)

   

173 (17.4)

Butt 2021 [31]

PCR positive

393

30.67 ± 5.21

           

PCR negative

862

31.33 ± 5.2

           

Collier 2021 [32]

Pregnant Vaccinated women

30

34.33 ± 3.11

 

10 (33%)

 

0

3 (11)

1 (4)

 

24 (86)

 

1 (4)

 

Pregnant Unvaccinated and infected women

22

31.67 ± 6.34

   

5 (28)

0

3 (17)

 

10 (56)

 

4 (21)

 

Dagan 2021 [33]

Pregnant Vaccinated women

10,861

29.67 ± 5.19

 

2,805 (26%)

        

1,048 (9.6%)

Pregnant Unvaccinated and infected women

10,861

29.67 ± 5.19

          

1,019 (9.4%)

Kharbanda 2021 [35]

Ongoing pregnancy periods (vaccinated women)

20,139

    

715 (3.8)

4433 (12.3)

  

7571 (9.3)

2213 (7.8)

5207 (6.0)

 

Spontaneous abortions (vaccinated women)

1128

    

48 (4.4)

262 (12.9)

  

373 (8.7)

123 (8.6)

322 (7.4)

 

Rottenstreich 2021 [36]

Covid‐19 vaccinated Pregnant women

712

30.6 ± 5.8

          

101 (14.2%)

Covid‐19 Unvaccinated Pregnant women

1063

29.5 ± 6

          

140 (13.2%)

Shanes 2021 [37]

Pregnant Vaccinated women

84

33.7 ± 3.1

           

Pregnant Unvaccinated women

116

32.5 ± 4.8

           

Theiler 2021 [38]

Covid‐19 vaccinated Pregnant women

140

31.8 ± 3.7

   

3 (2.2)

6 (4.3)

  

128 (92.1)

1

5 (3.6)

 

Covid‐19 Unvaccinated Pregnant women

1862

30.5 ± 5.2

   

99 (5.4)

89 (4.8)

  

1528 (82.9)

18

173 (9.5)

 

Wainstock 2021 [39]

Covid‐19 vaccinated Pregnant women

913

30.6 ± 5.3

          

152 (16.6)

Covid‐19 Unvaccinated Pregnant women

3486

28.2 ± 5.7

          

549 (15.7)

Pfizer BioNTech C4591001

BNT162b2 (30 μg)

18,860

    

1729 (9.2)

801 (4.2)

449 (2.4)

93 (0.5)

15,636 (82.9)

 

5266 (27.9)

6556 (34.8)

Placebo

18,846

    

1763 (9.4)

807 (4.3)

406 (2.2)

115 (0.6)

15,630 (82.9)

 

5277 (28.0)

6662 (35.3)

Moderna mRNA-1273-P301

Moderna COVID-19 Vaccine mRNA-1273

15,208

    

1562 (10.3)

653 (4.3)

315 (2.1)

 

12,032 (79.2)

321 (2.1)

3121 (20.6)

 

Placebo

15,210

    

1528 (10.1)

732 (4.8)

319 (2.1)

 

11,990 (79.1)

315 (2.1)

3112 (20.5)

 

COV003 (Brazil)

ChAdOx1nCoV-19

3414

 

26.07 ± 4.45

  

337 (9.9%)

83 (2.4%)

704 (20.6%)

 

2273 (66.6%)

17 (0.5%)

  

MenACWY "control vaccine" (first dose), Saline (second dose)

3339

 

26.17 ± 4.6

  

336 (10.1%)

66 (2.0%)

670 (20.1%)

 

2249 (67.4%)

18 (0.5%)

  
Back to article page

BMC Pregnancy and Childbirth

ISSN: 1471-2393

Contact us