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Table 3 Relationship between VitD intake and obstetric outcomes among women who conceived with ART

From: Preconception vitamin D intake and obstetric outcomes in women using assisted reproductive technology: the Japan Environment and Children’s Study

 

Quintile for VitD

 

Q1 (low)

Q2

Q3

Q4

Q5 (high)

p-valuea

n = 383

n = 530

n = 578

n = 587

n = 516

VitD intake before pregnancy, μg/day, median (IQR)

1.5 (1.0–1.9)

3.0 (2.6–3.3)

4.3 (4.0–4.7)

6.0 (5.4–6.6)

10.0 (8.5–12.1)

 

PTB at < 37 weeks

 Number, n

30

35

29

40

50

 

 Occurrence, %

7.8

6,6

5.0

6.8

9.7

0.206

 aOR (95% CI)

1.64 (0.96–2.78)

1.32 (0.79–2.20)

1 (Ref)

1.41 (0.86–2.30)

2.05 (1.27–3.31)

 

PTB at < 34 weeks

 Number, n

7

9

7

14

13

 

 Occurrence, %

1.8

1.7

1.2

2.4

2.5

0.251

 aOR (95% CI)

1.50 (0.52–4.34)

1.37 (0.50–3.72)

1 (Ref)

2.03 (0.81–5.09)

1.90 (0.74–4.87)

 

LBW < 2500 g

 Number, n

45

50

52

50

57

 

 Occurrence, %

11.7

9.4

9.0

8.5

11.1

0.727

 aOR (95% CI)

1.30 (0.85–2.00)

1.04 (0.69–1.57)

1 (Ref)

0.97 (0.65–1.46)

1.27 (0.85–1.89)

 

LBW < 1500 g

 Number, n

8

7

5

8

9

 

 Occurrence, %

2.1

1.3

0.9

1.4

1.8

0.850

 aOR (95% CI)

2.36 (0.76–7.33)

1.45 (0.45–4.64)

1 (Ref)

1.63 (0.53–5.04)

1.79 (0.58–5.54)

 

SGA

 Number, n

26

28

32

32

20

 

 Occurrence, %

6.8

5.3

5.5

5.5

3.9

0.105

 aOR (95% CI)

1.21 (0.70–2.09)

0.94 (0.55–1.60)

1 (Ref)

1.01 (0.61–1.68)

0.65 (0.36–1.17)

 

HDP

 Number, n

19

28

27

31

24

 

 Occurrence, %

5.0

5.3

4.7

5.3

4.7

0.841

 aOR (95% CI)

1.01 (0.55–1.84)

1.00 (0.57–1.74)

1 (Ref)

1.16 (0.68–1.97)

0.93 (0.53–1.65)

 
  1. VitD Vitamin D, ART Assisted reproductive technology, IQR Interquartile range, PTB Preterm birth, aOR Adjusted odds ratio, CI Confidence interval, Ref Reference, LBW Low-birth weight infant, SGA Small for gestational age, HDP Hypertensive disorder of pregnancy
  2. aOR was calculated by logistic regression analysis, using maternal age (20–29 years as reference), body mass index before pregnancy, maternal smoking status, maternal education, endometriosis, parity, and daily calorie intake
  3. a Mantel–Haenszel’s chi-square test for linear trends