Variable | Quintile for VitD | |||||
---|---|---|---|---|---|---|
Q1 (low) | Q2 | Q3 | Q4 | Q5 (high) | ||
n = 18,592 | n = 18,439 | n = 18,368 | n = 18,636 | n = 18,536 | P-value | |
Maternal medical background | ||||||
VitD intake before pregnancy, μg/day, median (IQR) | 1.4 (0.8–1.8) | 3.0 (2.6–3.3) | 4.3 (4.0–4.7) | 6.0 (5.5–6.7) | 10.2 (8.6–12.8) | < 0.001a |
Maternal age, years, mean (SD) | 30.0 (5.3) | 31.0 (5.0) | 31.4 (4.9) | 31.8 (4.8) | 31.8 (4.9) | < 0.001b |
Advanced maternal age, % | ||||||
< 20 | 1.6 | 0.7 | 0.5 | 0.5 | 0.6 | < 0.001c |
20–29 | 45.7 | 37.7 | 35.1 | 31.6 | 31.8 | |
30–39 | 49.1 | 57.4 | 59.6 | 62.8 | 62.3 | |
> 40 | 3.6 | 4.1 | 4.8 | 5.2 | 5.3 | |
BMI before pregnancy (kg/m2), % | ||||||
< 18.5 | 17.2 | 16.6 | 15.8 | 15.7 | 15.1 | < 0.001c |
18.5–25.0 | 71.7 | 73.1 | 74.0 | 73.9 | 73.1 | |
> 25.0 | 11.1 | 10.3 | 10.2 | 10.4 | 11.8 | |
Smoking during pregnancy, % | 6.6 | 4.7 | 4.3 | 3.9 | 4.6 | < 0.001c |
Primipara, % | 51.3 | 42.5 | 39.2 | 35.8 | 32.7 | < 0.001c |
ART pregnancy, % | 2.2 | 3.0 | 3.3 | 3.2 | 2.9 | < 0.001c |
Chronic Hypertension, % | 1.3 | 1.1 | 1.1 | 1.2 | 1.3 | 0.240 |
Glucose intolerance, % | 1.6 | 1.7 | 1.8 | 1.6 | 2.1 | 0.002 |
Endometriosis, % | 3.0 | 3.6 | 3.8 | 3.8 | 3.9 | < 0.001c |
Maternal education, years, % | ||||||
< 10 | 7.1 | 4.6 | 4.1 | 3.8 | 4.5 | < 0.001c |
10–12 | 38.6 | 32.9 | 29.6 | 27.5 | 29.1 | |
13–16 | 38.7 | 41.8 | 43.1 | 42.9 | 44.2 | |
> 17 | 15.7 | 20.8 | 23.2 | 25.8 | 22.2 | |
Annual household income, % | ||||||
< 2,000,000 JPY | 8.7 | 5.4 | 4.5 | 4.2 | 5.6 | < 0.001c |
2,000,000–5,999,999 JPY | 69.6 | 68.7 | 67.7 | 66.1 | 66.0 | |
6,000,000–9,999,999 JPY | 18.5 | 21.9 | 23.4 | 24.7 | 23.7 | |
> 10,000,000 JPY | 3.3 | 3.9 | 4.5 | 4.9 | 4.7 | |
Daily calorie intake, kcal/day, median (IQR) | 1307 (1049–1939) | 1523 (1282–1813) | 1657 (1416–1952) | 1881 (1594–2637) | 2254 (1850–3578) | < 0.001a |
Obstetric outcomes | ||||||
PTB at < 37 weeks, % | 4.5 | 4.8 | 4.5 | 4.4 | 4.8 | 0.768d |
PTB at < 34 weeks, % | 0.9 | 1.0 | 0.9 | 0.8 | 1.0 | 0.676d |
LBW < 2500 g, % | 8.2 | 8.3 | 7.8 | 7.5 | 8.2 | 0.175d |
LBW < 1500 g, % | 0.6 | 0.6 | 0.5 | 0.5 | 0.6 | 0.443d |
SGA, % | 5.1 | 5.0 | 4.6 | 5.0 | 5.6 | 0.031d |
HDP, % | 3.3 | 3.1 | 2.9 | 3.1 | 3.1 | 0.360d |