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Table1 Reported immature ovarian teratoma in pregnancy

From: Fast-growing immature ovarian teratoma during pregnancy: a case report and a review of the literature

Case

Author

Age, y

GA

at discovery

Tumor Size

(at discovery)

CT regimen

/GA at start

/cycle(s)

Operation/GA

Stage

Delivery mode/GA (at delivery)

Tumor Size (at operation)

Tumor markera

Fetal outcome

Maternal outcome

1

Hassan A A et al. 1984 [6]

28

28w

N/A

Vincristine + actinomycin D + cyclophosphamide/Postpartum/1

Right salpingo-ophorectomy + partial omentectomy/29w

N/A

CS/29w

22 × 20 × 11 cm

N/A

1050 g

Died 3 months after the

operation

2

Christman J E et al. 1990 [7]

29

6w

18 × 20

cm

Cisplatin + vinblastine + bleomycin/19w/1

Cisplatin + vinblastine + bleomycin/Pos-tpartum/3

Right salpingo-oophorectomy + surgical staging

procedure /15w

Peritoneal washings + peritoneal biopsies + 

hysterectomy + omentectomy + pelvic and paraaortic lymphadenectomy/Po-stpartum

IC

VD/37w

N/A

N/A

Male,3232 g

Apgar 8,9 (1st, 5th min), normal

Follow-up good

52 months after CT

follow-up good

3

Poremba C et al. 1993 [8]

27

38w

8 × 6 × 4.5 cm

N/A

N/A

N/A

CS/38w

8 × 6 × 4.5 cm

N/A

Female,hydroceph-alus(intracranial

teratoma)

The fetal survived only 9 weeks

N/A

4

Horbelt D et al. 1994 [9]

18

18w

5.2 × 9.4 × 8.6 cm

BEP/21w/3

Right oophorectomy + infracolic mentectomy + perit-oneal biopsies

/20w

IA

VD/39w

236 g

AFP 477.8 IU / mL (18w)

Female,2769 g

Apgar 4,7(1st, 5th min)

Anemia after delivery

Normal development

N/A

5

O'Connor D M,et al. 1994 [10]

N/A

N/A

N/A

N/A

N/A

I

N/A

N/A

N/A

N/A

N/A

6

N/A

N/A

N/A

N/A

N/A

I

N/A

N/A

N/A

N/A

N/A

7

N/A

N/A

N/A

N/A

N/A

I

N/A

N/A

N/A

N/A

N/A

8

Whitecar M P et al. 1999 [11]

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

N/A

9

Bakri Y N 2000 [12]

21

8w

N/A

N/A

Total abdominal hysterectomy + bilateral salpingo-oophorectomy/N/A

III Undetermined?

N/A

N/A

N/A

N/A

Died at the second trimester

10

Kishimoto K et al. 2002 [13]

28

35w

18 × 17 × 11 cm

Receive five cycles of CT postpartum (the regimen is not recorded)

Abdominal total simple hysterectomy + bilateral salpingo-

ophrectomy + pelvic and paraaortic lymphadenectomy + partial omentectomy/N/A

IIIC

CS/38w

20 × 15 × 13

cm

AFP 830.1 ng/ml(35w)

2308 g and the post-operative course

was uneventful

Remains alive 9 months after delivery

11

Agarwal N et al. 2003 [14]

N/A

N/A

N/A

N/A

Excision of growth /33w

NA

CS/33w

N/A

N/A

N/A

N/A

12

Han J Y et al. 2005 [15]

27

24w

6 × 5 cm

BEP/30w/2

BEP/Postpartum/3

Right salpingo-oophorectomy

/26w

Laparoscopic dissection of bilateral

pelvic + paraaortic lymph nodes + omentectomy + biopsy

of left ovary/Postpartum

IA

VD/38w

N/A

AFP 268 IU/ml(16w)

Male, 2970 g

Apgar score 9–10(1st, 5th min)

26 months after follow-up normal physiological and

neurological development

26 months of follow-up and no evidence of

malignant tumor

13

Zhao X Y et al. 2006 [16]

24

17 + w

N/A

N/A

Left salpingo-oophorectomy/17 + w

I

N/A/37w

N/A

N/A

Term infant

DFS 30 months

14

 

24

8 + w

N/A

N/A

Right salpingo-oophorectomy/13 + w

I

N/A/37w

N/A

N/A

Term infant

DFS 18 months

15

Karimi Z M et al. 2008 [17]

26

28w

24 × 16 cm

BEP/29w/2

BEP/Postpartum/2

Peritoneal cytology + right oophorectomy + partial omentectomy/28w

Complete omentectomy + ipsilateral lymph node sampling/39w

IIIC

CS/39w

 

CA125 210 IU/ml;

AFP 480 IU/

ml(28 w)

Female, 3100 g Apgar score 9–10 (1st,5th min)

Followed up 1.5 years, normal physical and neurological

development

Without any evi-

dence of tumor recurrence for 1.5 years

16

Daponte A et al. 2008 [18]

33

5w

7 × 7 cm

N/A

Right salpingo-oophorectomy and

surgical staging (peritoneal washings, peritoneal and omentum

biopsies)/N/A

Inspect the peritoneal cavity and biopsies/34w

IA

CS/34w

N/A

AFP 15.94 IU/ml;

CA-125 89.6 U/ml(12w)

Healthy infant

After two years no recurrence

17

Poujade O et al. 2008 [19]

36

21w

17.5 cm in diameter

Etoposide and cisplatin/23w/3

Etoposide and cisplatin/Postpartum/2

Left ovariectomy/22w

Left salpingectomy/39w

N/A

CS/39w

18 cm in diameter

N/A

3130 g. The

Apgar score 10–10-10 (1st,5th,10th min)

With normal aspect

In remission six months later

18

Ghaemmaghami F et al. 2009 [20]

25

13w

76 × 45 mm

BEP/N/A/3

Right oophorectomy + biopsy of the left ovary + 

omentum /21w

Partial omen-

tectomy + right salpingectomy + perito-neal biopsy + bilateral

lymph node sampling/36 w

N/A

CS/36w

N/A

N/A

Male,2000 g

Apgar score of 9–10 at 15 min(with normal appearance

with a mild hypospadias)

Normal physical and neurological development after 8 months of birth

Show no evidence of tumor recurrence after

one year

19

Clinkard D J et al. 2011 [21]

23

16w

13 cm

Cisplatinum + etoposide/After abortion/3

Acute surgical exploration/N/A

Bilateral oophorectomy + infra-colic omentectomy/N/A

IIIC

Abortion/N/A

N/A

N/A

The fetus spontaneously

aborted shortly after the surgery

Six years later alive and delivered a baby

20

Moradan S et al. 2014 [22]

21

18w

18 × 20 cm

N/A

Salpingo-oophorectomy and surgical staging/19w

Inspect peritoneal cavity and biopsies were taken

from the peritoneum, pelvic wall, left ovary and omentum/38w

IA

CS/38w

N/A

AFP 117 ng/ml;

β-HCG/CA125 normal(18w)

Male,2900 g

N/A

21

Luh L et al. 2019 [3]

31

8 + 1w

15 × 15 × 15 cm

BEP/27 + 2w/4

Left oophorectomy + omentectomy + ascites fluid cytology/N/A

Total abdominal hysterectomy + salpingectomy sinistra + SOD + 

lymphadenectomy pelvic bilateral and paraaortic + omentectomy + perit-oneal biopsy/Postpartum

N/A

N/A/40 + 2w

40 × 40 × 40 cm

AFP 699.9

IU/mL;

LDH 579 U/L (19 + 5 w)

Female,2700 g Apgar score 7–8 (1st,5th min)

Not seen a congenital abnormality

N/A

22

Cochrane E et al. 2020 [23]

26

23w

10.9 × 8.2 × 9.9 cm

BEP/N/A/2

Three cycles of chemotherapy in postpartum(the regimen is not recorded)

Left salpingo-oophorectomy + 

infracolic omentectomy + left pelvic side-wall biopsy/26w

Excision of an anterior peritoneal mass/Postpartum

IIIA

VD/37w

N/A

AFP 1567 ng/mL;

CA-125 233.4 U/mL;

CA-199 93.1 U/ml(26w)

Female,1790 g

Apgar scores 8–9 (1st,5th min)

Follow-up 25 months the growth and development normal

Follow-up without further benign or malignant disease

23

Present Case

28

29w

9.7 × 8.5 × 6.4 cm

BEP/Postpartum/4

Left salpingo-oophorectomy + pelvic mass resection + right ovarian biopsy + bilateral pelvic lymph node dissection + para-aortic lymph node sampling + omentectomy/33w

IC

CS/32w

35 × 20 × 15 cm

CA-125 43.4 U/mL; AFP 173.4 ng/mL(30w)

Female,1610 g

Apgar scores 9–10-10

(1st,5th,10th)

No evidence of recurrence with 18 months of follow-up after surgery

  1. AFP alpha fetoprotein, BEP bleomycin (BLM) + etoposide (VP16) + cisplatin (DDP), CS cesarean section, CT chemotherapy, DFS disease free survival, GA gestational age, β-HCG β- human chorionic gonadotropin, N/A not available, LDH lactate dehydrogenase, VD vaginal delivery
  2. Tumor marker arefers to the first recorded level of serum tumor markers