Case | Author | Age, y | GA at discovery | Tumor Size (at discovery) | CT regimen /GA at start /cycle(s) | Operation/GA | Stage | Delivery mode/GA (at delivery) | Tumor Size (at operation) | Tumor markera | Fetal outcome | Maternal outcome |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Hassan A A et al. 1984 [6] | 28 | 28w | N/A | Vincristine + actinomycin D + cyclophosphamide/Postpartum/1 | Right salpingo-ophorectomy + partial omentectomy/29w | N/A | CS/29w | 22 × 20 × 11 cm | N/A | 1050 g | Died 3 months after the operation |
2 | Christman J E et al. 1990 [7] | 29 | 6w | 18 × 20 cm | Cisplatin + vinblastine + bleomycin/19w/1 Cisplatin + vinblastine + bleomycin/Pos-tpartum/3 | Right salpingo-oophorectomy + surgical staging procedure /15w Peritoneal washings + peritoneal biopsies + hysterectomy + omentectomy + pelvic and paraaortic lymphadenectomy/Po-stpartum | IC | VD/≧37w | N/A | N/A | Male,3232 g Apgar 8,9 (1st, 5th min), normal Follow-up good | 52 months after CT follow-up good |
3 | Poremba C et al. 1993 [8] | 27 | 38w | 8 × 6 × 4.5 cm | N/A | N/A | N/A | CS/38w | 8 × 6 × 4.5 cm | N/A | Female,hydroceph-alus(intracranial teratoma) The fetal survived only 9 weeks | N/A |
4 | Horbelt D et al. 1994 [9] | 18 | 18w | 5.2 × 9.4 × 8.6 cm | BEP/21w/3 | Right oophorectomy + infracolic mentectomy + perit-oneal biopsies /20w | IA | VD/39w | 236 g | AFP 477.8 IU / mL (18w) | Female,2769 g Apgar 4,7(1st, 5th min) Anemia after delivery Normal development | N/A |
5 | O'Connor D M,et al. 1994 [10] | N/A | N/A | N/A | N/A | N/A | I | N/A | N/A | N/A | N/A | N/A |
6 | N/A | N/A | N/A | N/A | N/A | I | N/A | N/A | N/A | N/A | N/A | |
7 | N/A | N/A | N/A | N/A | N/A | I | N/A | N/A | N/A | N/A | N/A | |
8 | Whitecar M P et al. 1999 [11] | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
9 | Bakri Y N 2000 [12] | 21 | 8w | N/A | N/A | Total abdominal hysterectomy + bilateral salpingo-oophorectomy/N/A | III Undetermined? | N/A | N/A | N/A | N/A | Died at the second trimester |
10 | Kishimoto K et al. 2002 [13] | 28 | 35w | 18 × 17 × 11 cm | Receive five cycles of CT postpartum (the regimen is not recorded) | Abdominal total simple hysterectomy + bilateral salpingo- ophrectomy + pelvic and paraaortic lymphadenectomy + partial omentectomy/N/A | IIIC | CS/≧38w | 20 × 15 × 13 cm | AFP 830.1 ng/ml(35w) | 2308 g and the post-operative course was uneventful | Remains alive 9 months after delivery |
11 | Agarwal N et al. 2003 [14] | N/A | N/A | N/A | N/A | Excision of growth /33w | NA | CS/33w | N/A | N/A | N/A | N/A |
12 | Han J Y et al. 2005 [15] | 27 | 24w | 6 × 5 cm | BEP/30w/2 BEP/Postpartum/3 | Right salpingo-oophorectomy /26w Laparoscopic dissection of bilateral pelvic + paraaortic lymph nodes + omentectomy + biopsy of left ovary/Postpartum | IA | VD/38w | N/A | AFP 268 IU/ml(16w) | Male, 2970 g Apgar score 9–10(1st, 5th min) 26 months after follow-up normal physiological and neurological development | 26 months of follow-up and no evidence of malignant tumor |
13 | Zhao X Y et al. 2006 [16] | 24 | 17 + w | N/A | N/A | Left salpingo-oophorectomy/17 + w | I | N/A/≧37w | N/A | N/A | Term infant | DFS 30 months |
14 | 24 | 8 + w | N/A | N/A | Right salpingo-oophorectomy/13 + w | I | N/A/≧37w | N/A | N/A | Term infant | DFS 18 months | |
15 | Karimi Z M et al. 2008 [17] | 26 | 28w | 24 × 16 cm | BEP/29w/2 BEP/Postpartum/2 | Peritoneal cytology + right oophorectomy + partial omentectomy/28w Complete omentectomy + ipsilateral lymph node sampling/39w | IIIC | CS/39w | CA125 210 IU/ml; AFP 480 IU/ ml(28 w) | Female, 3100 g Apgar score 9–10 (1st,5th min) Followed up 1.5 years, normal physical and neurological development | Without any evi- dence of tumor recurrence for 1.5 years | |
16 | Daponte A et al. 2008 [18] | 33 | 5w | 7 × 7 cm | N/A | Right salpingo-oophorectomy and surgical staging (peritoneal washings, peritoneal and omentum biopsies)/N/A Inspect the peritoneal cavity and biopsies/34w | IA | CS/34w | N/A | AFP 15.94 IU/ml; CA-125 89.6 U/ml(12w) | Healthy infant | After two years no recurrence |
17 | Poujade O et al. 2008 [19] | 36 | 21w | 17.5 cm in diameter | Etoposide and cisplatin/23w/3 Etoposide and cisplatin/Postpartum/2 | Left ovariectomy/22w Left salpingectomy/39w | N/A | CS/39w | 18 cm in diameter | N/A | 3130 g. The Apgar score 10–10-10 (1st,5th,10th min) With normal aspect | In remission six months later |
18 | Ghaemmaghami F et al. 2009 [20] | 25 | 13w | 76 × 45 mm | BEP/N/A/3 | Right oophorectomy + biopsy of the left ovary + omentum /21w Partial omen- tectomy + right salpingectomy + perito-neal biopsy + bilateral lymph node sampling/36 w | N/A | CS/36w | N/A | N/A | Male,2000 g Apgar score of 9–10 at 15 min(with normal appearance with a mild hypospadias) Normal physical and neurological development after 8 months of birth | Show no evidence of tumor recurrence after one year |
19 | Clinkard D J et al. 2011 [21] | 23 | 16w | 13 cm | Cisplatinum + etoposide/After abortion/3 | Acute surgical exploration/N/A Bilateral oophorectomy + infra-colic omentectomy/N/A | IIIC | Abortion/N/A | N/A | N/A | The fetus spontaneously aborted shortly after the surgery | Six years later alive and delivered a baby |
20 | Moradan S et al. 2014 [22] | 21 | 18w | 18 × 20 cm | N/A | Salpingo-oophorectomy and surgical staging/19w Inspect peritoneal cavity and biopsies were taken from the peritoneum, pelvic wall, left ovary and omentum/38w | IA | CS/38w | N/A | AFP 117 ng/ml; β-HCG/CA125 normal(18w) | Male,2900 g | N/A |
21 | Luh L et al. 2019 [3] | 31 | 8 + 1w | 15 × 15 × 15 cm | BEP/27 + 2w/4 | Left oophorectomy + omentectomy + ascites fluid cytology/N/A Total abdominal hysterectomy + salpingectomy sinistra + SOD + lymphadenectomy pelvic bilateral and paraaortic + omentectomy + perit-oneal biopsy/Postpartum | N/A | N/A/40 + 2w | 40 × 40 × 40 cm | AFP 699.9 IU/mL; LDH 579 U/L (19 + 5 w) | Female,2700 g Apgar score 7–8 (1st,5th min) Not seen a congenital abnormality | N/A |
22 | Cochrane E et al. 2020 [23] | 26 | 23w | 10.9 × 8.2 × 9.9 cm | BEP/N/A/2 Three cycles of chemotherapy in postpartum(the regimen is not recorded) | Left salpingo-oophorectomy + infracolic omentectomy + left pelvic side-wall biopsy/26w Excision of an anterior peritoneal mass/Postpartum | IIIA | VD/37w | N/A | AFP 1567 ng/mL; CA-125 233.4 U/mL; CA-199 93.1 U/ml(26w) | Female,1790 g Apgar scores 8–9 (1st,5th min) Follow-up 25 months the growth and development normal | Follow-up without further benign or malignant disease |
23 | Present Case | 28 | 29w | 9.7 × 8.5 × 6.4 cm | BEP/Postpartum/4 | Left salpingo-oophorectomy + pelvic mass resection + right ovarian biopsy + bilateral pelvic lymph node dissection + para-aortic lymph node sampling + omentectomy/33w | IC | CS/32w | 35 × 20 × 15 cm | CA-125 43.4 U/mL; AFP 173.4 ng/mL(30w) | Female,1610 g Apgar scores 9–10-10 (1st,5th,10th) | No evidence of recurrence with 18 months of follow-up after surgery |