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Table 3 Crude and adjusted associations (ß estimates and 95% confidence intervals) between placental morphological features and child raw total SRS scores

From: Placental morphology in association with autism-related traits in the EARLI study

Variablea

n

Crude

Model 1b

Model 2c

ß (95% CI)

ß (95% CI)

ß (95% CI)

Perimeter (cm)

84

−0.22 (− 0.97, 0.53)

0.11 (− 0.62, 0.84)

0.10 (− 0.64, 0.84)

Area (cm2)

84

− 0.02 (− 0.13, 0.09)

0.03 (− 0.07, 0.14)

0.03 (− 0.08, 0.14)

Radius (cm)

 Minimum

84

−2.3 (−5.22, 0.61)

− 1.01 (−3.92, 1.89)

− 1.04 (−3.97, 1.88)

 Maximum

84

1.73 (− 0.76, 4.23)

1.16 (− 1.19, 3.51)

1.14 (− 1.23, 3.51)

 Median

84

1.96 (−3.09, 7.00)

2.67 (− 2.03, 7.38)

2.63 (− 2.15, 7.41)

Umbilical cord centrality/distance from center (cm)

84

2.3 (− 0.50, 5.10)

1.12 (−1.64, 3.89)

1.12 (− 1.67, 3.90)

Eccentricity

 Eccentricity from Geometric center

84

0.31 (−23.10, 23.71)

2.96 (−19.42, 25.34)

3.05 (−19.47, 25.58)

 Eccentricity from cord insertion point

84

1.95 (0.69, 3.21)

1.68 (0.47, 2.89)

1.68 (0.45, 2.9)

Thickness of traced central slice (cm)

 Maximum

81

17.00 (−1.08, 35.09)

17.00 (0.20, 33.79)

17.12 (−0.003, 34.24)

 Mean

81

13.37 (−9.88, 36.62)

12.41 (−9.32, 34.14)

12.29 (−9.70, 34.29)

Thickness of traced central slice (cm) (Z score)

 Maximum

81

5.69 (− 0.36, 11.74)

5.69 (0.07, 11.30)

5.73 (− 0.00, 11.46)

 Mean

81

3.48 (−2.57, 9.52)

3.23 (−2.42, 8.88)

3.20 (− 2.52, 8.91)

Placental weight (g)

79

0.04 (−0.03, 0.11)

0.06 (−0.01, 0.13)

0.06 (− 0.02, 0.13)

Birthweight: Placental Weight

79

−2.99 (−9.31, 3.34)

−5.82 (−12.15, 0.51)

−6.05 (− 12.42, 0.31)

  1. aPlacental eccentricity is the ratio of the maximum radius divided by the minimum radius from the geometric center or the umbilical insertion point; a round placenta with a centrally inserted umbilical cord would have a cord eccentricity of 1
  2. bModel 1 adjusted for child sex, maternal age, maternal education level, maternal pre-pregnancy BMI
  3. cModel 2 adjusted for all covariates from Model 1 and additionally adjusted for child gestational age. Additional adjustment for maternal race/ethnicity did not materially alter results