Prepregnancy body mass index, gestational weight gain, and maternal prepartum inflammation in normal pregnancies: findings from a Chinese cohort

Table 3 Adjusted associations of pBMI and tGWG with maternal prepartum CSI and LGI (n = 5476)

	No. prepartum inflammation/total no	RR (95% CI)^a	P	P_trend
Maternal prepartum CSI (n = 394)^b
pBMI
< 18.5 kg/m²	70/1193	1.00
18.5 – 24.9 kg/m²	290/3986	1.35 (1.05–1.74)	0.020
≥ 25.0 kg/m²	34/297	2.28 (1.53–3.39)	< 0.001	< 0.001
tGWG tertiles
< 12.0 kg	118/1579	1.00
12.0 – 14.9 kg	103/1705	0.83 (0.64–1.07)	0.150
≥ 15.0 kg	173/2192	1.07 (0.86–1.35)	0.534	0.339
Maternal prepartum LGI (n = 2617)^c
pBMI
< 18.5 kg/m²	507/1123	1.00
18.5 – 24.9 kg/m²	1935/3696	1.19 (1.11–1.28)	< 0.001
≥ 25.0 kg/m²	175/263	1.59 (1.42–1.77)	< 0.001	< 0.001
tGWG tertiles
< 12.0 kg	706/1461	1.00
12.0 – 14.9 kg	790/1602	1.04 (0.96–1.12)	0.312
≥ 15.0 kg	1121/2019	1.17 (1.09–1.25)	< 0.001	< 0.001

^apBMI and tGWG were mutually adjusted for in the multivariable models. The multivariable models also adjusted for maternal age, parity, and gestational length
^bMaternal prepartum CSI was defined as maternal prepartum serum CRP concentration > 10 mg/L
^cMaternal prepartum LGI was defined as maternal prepartum serum CRP concentration ≥ 3.0 and ≤ 10 mg/L. Women with prepartum CSI were excluded
CI Confidence interval, CRP C-reactive protein, CSI clinically significant inflammation, LGI low-grade inflammation, pBMI prepregnancy body mass index, RR relative risk, tGWG total gestational weight gain

ISSN: 1471-2393