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Table 3 Interaction term analyses between FT4 or TSH concentrations and gestational age at the thyroid function test on risk of preterm birth

From: Association of thyroid dysfunction and autoantibody positivity with the risk of preterm birth: a hospital-based cohort study

Interaction term

Total sample

Women with a test ≤18 weeks of gestation

Women with a test > 18 weeks of gestation

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

FT4 concentrations (pmol/L)

0.98 (0.92–1.04)

0.44

1.13 (1.00–1.28)

0.044

0.68 (0.48–0.97)

0.035

Gestational age at the test (weeks)

0.98 (0.93–1.03)

0.34

1.15 (1.01–1.32)

0.038

0.82 (0.70–0.97)

0.017

FT4 by gestational age at test

1.00 (1.00–1.01)

0.58

0.99 (0.98–1.00)

0.032

1.02 (1.00–1.03)

0.025

TSH concentrations (uIU/mL)

1.04 (0.92–1.18)

0.90

0.97 (0.74–1.25)

0.79

0.95 (0.55–1.64)

0.84

Gestational age at the test (weeks)

1.00 (0.98–1.02)

0.50

1.00 (0.96–1.04)

0.99

0.99 (0.94–1.04)

0.65

TSH by gestational age at test

1.00 (0.99–1.00)

0.26

1.00 (0.98–1.02)

0.89

1.00 (0.98–1.02)

0.90

  1. Adjusted factors included maternal age (years), residence (local or nonlocal), parity (nulliparous or pluriparous), assisted conception (yes or no), fetal sex (male or female), gestational diabetes (yes or no) and preeclampsia (yes or no)