Table 2 Changes in use of antiemetics and clinical characteristics associated with hyperemesis treatment guideline update (intervention) in 2014
Beta- coefficient | 95% confidence interval | |
|---|---|---|
a) Antiemetics prior to hospitalization | ||
Any antiemetic (%) | ||
Trend pre-intervention, β1 | 2.52 | 1.17; 3.87 |
Level change at intervention, β2 | -19.7 | -33.8; -5.71 |
Trend change post-intervention, β3 | 1.98 | -0.67; 4.63 |
Post-intervention trend, β1 + β3 | 4.50 | 1.99; 7.02 |
p < 0.001 | ||
Metoclopramide (%) | ||
Trend pre-intervention, β1 | 2.22 | 1.29; 3.14 |
Level change at intervention, β2 | -30.2 | -35.6; -24.8 |
Trend change post-intervention, β3 | 2.65 | 0.26; 5.03 |
Post-intervention trend, β1 + β3 | 4.86 | 2.68; 7.04 |
p < 0.001 | ||
Prochlorperazine (%) | ||
Trend pre-intervention, β1 | 0.01 | -0.47; 0.49 |
Level change at intervention, β2 | -0.86 | -6.19; 4.47 |
Trend change post-intervention, β3 | 2.05 | 0.35; 3.75 |
Post-intervention trend, β1 + β3 | 2.06 | 0.48; 3.64 |
p = 0.022 | ||
b) Antiemetics while at hospital | Beta- coefficient | 95% confidence interval |
Any antiemetic (%) | ||
Trend pre-intervention, β1 | 1.28 | 0.64; 1.91 |
Level change at intervention, β2 | -3.64 | -9.64; 2.36 |
Trend change post-intervention, β3 | -1.69 | -2.86; -0.52 |
Post-intervention trend, β1 + β3 | -0.42 | -1.48; 0.65 |
p = 0.002 | ||
Metoclopramide (%) | ||
Trend pre-intervention, β1 | -2.88 | -5.05; -0.70 |
Level change at intervention, β2 | -19.8 | -36.7; -2.90 |
Trend change post-intervention, β3 | 1.07 | -1.48; 3.62 |
Post-intervention trend, β1 + β3 | -1.80 | -2.97; -0.64 |
p < 0.001 | ||
Prochlorperazine (%) | ||
Trend pre-intervention, β1 | -0.16 | -2.12; 1.80 |
Level change at intervention, β2 | 40.5 | 18.2; 62.8 |
Trend change post-intervention, β3 | 2.86 | 0.51; 5.21 |
Post-intervention trend, β1 + β3 | 2.70 | 0.52; 4.88 |
p < 0.001 | ||
c) Clinical characteristics and outcomes | Beta- coefficient | 98.75% confidence interval |
Mean gestational age at first admission (days) | ||
Trend pre-intervention, β1 | 0.33 | 0.15; 0.49 |
Level change at intervention, β2 | -3.8 | -7.1; -0.55 |
Trend change post-intervention, β3 | -0.24 | -1.28; 0.80 |
Post-intervention trend, β1 + β3 | 0.09 | -0.93; 1.10 |
p < 0.001 | ||
Mean weight change at first admission (% of pre-pregnancy weight) | ||
Trend pre-intervention, β1 | -0.01 | -0.09; 0.07 |
Level change at intervention, β2 | 0.90 | -0.23; 2.02 |
Trend change post-intervention, β3 | 0.16 | -0.14; 0.47 |
Post-intervention trend, β1 + β3 | 0.15 | -0.15; 0.45 |
p = 0.0044 | ||
Admission rate (% of births) | ||
Trend pre-intervention, β1 | -0.00 | -0.03; 0.03 |
Level change at intervention, β2 | 0.11 | -0.27; 0.49 |
Trend change post-intervention, β3 | 0.02 | -0.10; 0.13 |
Post-intervention trend, β1 + β3 | 0.02 | -0.10;0.13 |
p = 0.474 | ||
Rate of termination of pregnancy (% of admissions) | ||
Trend pre-intervention, β1 | -0.05 | -0.31; 0.21 |
Level change at intervention, β2 | 4.81 | 0.86; 8.74 |
Trend change post-intervention, β3 | -0.75 | -1.76; 0.25 |
Post-intervention trend, β1 + β3 | -0.81 | -1. 77; -0.15 |
p = 0.019 | ||