Fig. 7
Changes in clinical characteristics and outcomes in women hospitalized for hyperemesis gravidarum 2002–2019. Interrupted time-series analyses of (a) average gestational age at first admission, (b) average weight change at first admission in percent of pre-pregnancy weight, (c) admission rate, and (d) rate of termination of pregnancy in 1,064 women hospitalized for hyperemesis gravidarum in timely association with treatment guideline update in 2014. Predicted line visualizes linear trend pre-intervention in 2014 with slope corresponding to yearly change (β1); vertical line illustrating level change in 2014 at the time of treatment guideline update (β2); predicted line after 2014 representing post-intervention trend (β1 + β3) applying Newey-West standard errors to adjust for first order autocorrelation