Fig. 4

Interrupted time-series analysis of use of antiemetics prior to hospitalization for hyperemesis gravidarum 2002–2019. Percentage of 1.064 women hospitalized at Haukeland University Hospital using (a) metoclopramide, (b) prochlorperazine, and (c) any antiemetic prior to first hospitalization. Predicted line visualizes linear trend pre-intervention in 2014 with slope corresponding to yearly change (β₁); vertical line illustrating level change in 2014 at the time of treatment guideline update (β₂); predicted line after 2014 representing post-intervention trend (β₁ + β₃) applying Newey-West standard errors to adjust for first order autocorrelation