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Fig. 6 | BMC Pregnancy and Childbirth

Fig. 6

From: Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal–fetal inflammation in mice

Fig. 6

Clarithromycin downregulates inflammatory gene expression in the fetal liver and spleen. Expression (-ΔCT) of A Il1a, B Tnf, C Il12b, D Casp1, E Casp11, F Nod1, G Ccl5, H Ccl22, I Cxcl9, J Cxcl10, and K Tlr9 in the livers of fetuses from dams intra-amniotically injected with HMGB1 and treated with CLR (blue dots) or DMSO (red dots). Expression (-ΔCT) of L Nfkb2, M Il6, N Il1a, O Il18, P Ccl22, Q Nod1, and R Tlr9 in the spleens of fetuses from dams intra-amniotically injected with HMGB1 and treated with CLR (blue dots) or DMSO (red dots). Data are represented as box-and-whisker plots with medians, interquartile ranges, and min/max ranges. P-values were determined using the one-sided Mann–Whitney U-test

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