Fig. 5

Clarithromycin downregulates inflammatory gene expression in the fetal lung and intestine. Expression (-ΔC_T) of A Tnf and B Il12b in the lungs of fetuses from dams intra-amniotically injected with HMGB1 and treated with CLR (blue dots) or DMSO (red dots). Expression (-ΔC_T) of C Nfkb2, D Ifng, E Ccl5, F Cxcl9, G Tlr4, and H Tlr9 in the intestines of fetuses from dams intra-amniotically injected with HMGB1 and treated with CLR (blue dots) or DMSO (red dots). Data are represented as box-and-whisker plots with medians, interquartile ranges, and min/max ranges. P-values were determined using the one-sided Mann–Whitney U-test