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Table 3 The association of progesterone use in early pregnancy with the risk of offspring outcomes among women with bleeding in early pregnancy. (n = 1418)

From: The association of maternal vaginal bleeding and progesterone supplementation in early pregnancy with offspring outcomes: a prospective cohort study

Outcomes

Bleeding in early pregnancy

Non-treatment

Progesterone treatment

Very preterm (< 34 weeks of gestation)

 N(%)

14(1.9)

9(1.3)

 Unadjusted model

1

0.71(0.31–1.64)

 Adjusted model I*

1

0.63(0.27–1.48)

 Adjusted model IIa

1

0.61(0.26–1.43)

Preterm (< 37 weeks of gestation)

 N(%)

52(7.0)

38(5.6)

 Unadjusted model

1

0.80(0.52–1.23)

 Adjusted model I*

1

0.78(0.51–1.21)

 Adjusted model IIa

1

0.77(0.50–1.19)

SGA 

 N(%)

51(6.9)

54(8.0)

 Unadjusted model

1

1.18(0.80–1.76)

 Adjusted model I*

1

1.19(0.80–1.79)

 Adjusted model IIb

1

1.18(0.79–1.77)

LBW

 N(%)

32(4.3)

31(4.6)

 Unadjusted model

1

1.07(0.65–1.78)

 Adjusted model I*

1

1.05(0.63–1.75)

 Adjusted model IIb

1

1.83(0.93–3.60)

WAZ < -1 at 12 months of age (n = 675)

 N(%)

13(3.6)

16(5.1)

 Unadjusted model

1

1.45(0.69–3.06)

 Adjusted model I*

1

1.43(0.67–3.06)

 Adjusted model IIc

1

1.60(0.72–3.57)

  1. Data was shown as N(%) or OR(95%CI)
  2. SGA small for gestational age, LBW low birth weight, WAZ weight for age z-scores
  3. *Model I adjusted for maternal age, pre-pregnancy BMI, nulliparity, gravidity, history of spontaneous abortion, history of induced abortion, drinking before pregnancy, gestational age at enrollment
  4. aModel II adjusted for covariates in model I plus gestational weight gain, and fetal gender
  5. bModel II adjusted for covariates in model I plus gestational weight gain, gestational age at delivery and fetal gender
  6. cModel II adjusted for covariates in model I plus gestational weight gain, gestational age at delivery, fetal gender, birth weight, birth length, and any breastfeeding at 12 months