Table 2 Association between early vaginal bleeding and progesterone treatment and the risk of offspring outcomes (n = 6615)

Very preterm (< 34 weeks of gestation) 

 N(%)

24(0.5)

23(1.6)

35(0.6)

12(1.1)

 Unadjusted model

1

3.55(2.00–6.32)

1

1.83(0.95–3.53)

 Adjusted model I^*

1

3.50(1.83–6.68)

1

0.84(0.20–1.78)

 Adjusted model II^a

1

3.56(1.86–6.83)

1

0.85(0.40–1.79)

Preterm (< 37 weeks of gestation) 

 N(%)

171(3.3)

90(6.4)

207(3.7)

54(5.1)

 Unadjusted model

1

1.99(1.53–2.59)

1

1.40(1.03–1.91)

 Adjusted model I^*

1

1.95(1.45–2.63)

1

0.96(0.68–1.36)

 Adjusted model II^a

1

1.97(1.46–2.65)

1

0.96(0.68–1.37)

SGA

 N(%)

325(6.3)

105(7.4)

351(6.3)

79(7.5)

 Unadjusted model

1

1.20(0.95–1.51)

1

1.21(0.94–1.56)

 Adjusted model I^*

1

1.21(0.93–1.57)

1

1.19(0.89–1.60)

 Adjusted model II^b

1

1.23(0.94–1.60)

1

1.19(0.88–1.59)

LBW

 N(%)

104(2.0)

63(4.4)

126(2.3)

41(3.9)

 Unadjusted model

1

2.28(1.66–3.13)

1

1.75(1.23–2.51)

 Adjusted model I^*

1

2.13(1.47–3.08)

1

1.18(0.78–1.79)

 Adjusted model II^b

1

1.24(0.78–1.97)

1

1.63(0.98–2.72)

WAZ < -1 at 12 months of age (n = 3181)

 N(%)

70(2.8)

29(4.3)

80(3.0)

19(3.9)

 Unadjusted model

1

1.56(1.01–2.37)

1

1.33(0.80–2.22)

 Adjusted model I^*

1

1.53(0.93–2.53)

1

1.08(0.60–1.93)

 Adjusted model II^c

1

1.40(0.83–2.35)

1

1.13(0.62–2.05)