From: Prenatal sonographic findings in confirmed cases of Wolf-Hirschhorn syndrome
This study | Zhen et al., 2018 | Xing et al., 2018 | Xing et al., 2018 (rev.) | Sifakis et al., 2013b | Prenatal (prev. studies) | Prenatal (all) | Postnatala | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
All | n = 18 | % | n = 10 | n = 10 | n = 37 | n = 8 | n = 65 | % | n = 83 | % | |
IUGR | 15 | 83.3 | 5 | 10 | 33 | 5 | 53 | 81.5 | 68 | 81.9 | > 75% |
Microcephalyd | 13 | 72.2 | - | - | - | 3 | 3 | 4.6 | 16 | 19.3 | > 75% |
Oligo-/Anhydramnios | 3 | 16.7 | 4 | - | 2 | 4 | 10 | 15.4 | 13 | 15.7 | n/a |
NT > 95. percentile | 1 | 5.6 | 2 | 6 | 3 | 1 | 12 | 18.5 | 13 | 15.7 | n/a |
Cystic hygroma | 0 | 0.0 | 1 | 2 | 4 | 1 | 8 | 12.3 | 8 | 9.6 | n/a |
Facial anomalies (all): | 17 | 94.4 | - | 7e | 33e | 1e | 41 | 63.1 | 58 | 69.9 | > 75% |
- Absent/hypoplastic NBc | 13 | 72.2 | - | 5 | 1 | 0 | 6 | 9.2 | 19 | 22.9 | n/a |
- Cleft lip / palate | 5 | 27.8 | 1 | 1 | 11 | 2 | 15 | 23.1 | 20 | 24.1 | 25–50% |
- Retro-/Micrognathia | 5 | 27.8 | - | - | 1 | - | 1 | 1.5 | 6 | 7.2 | > 75% |
- An-/Microophthalmia | 1 | 5.6 | - | - | - | - | - | - | 1 | 1.2 | n/a |
- Hypertelorism | 1 | 5.6 | - | - | 2 | - | 2 | 3.1 | 3 | 3.6 | > 75% |
- PHPV | 1 | 5.6 | - | - | - | - | - | - | 1 | 1.2 | n/a |
Cerebral anomalies | 3 | 16.7 | - | 5 | 7 | 4 | 16 | 24.6 | 19 | 22.9 | 25–50% |
Cardiac anomalies | 9 | 50.0 | - | 5 | 9 | 2 | 16 | 24.6 | 25 | 30.1 | 25–50% |
Thoracic defects | 2 | 11.1 | - | - | 9 | 1 | 10 | 15.4 | 12 | 14.5 | < 25% |
Abdominal anomalies | 5 | 27.8 | - | - | 5 | 0 | 5 | 7.7 | 10 | 12.0 | < 25% |
SUA | 8 | 44.4 | - | - | 1 | 2 | 3 | 4.6 | 11 | 13.3 | n/a |
Urogenital anomalies | 6 | 33.3 | 2 | 3 | 18 | 2 | 25 | 38.5 | 31 | 37.3 | 25–50% |
Skeletal anomalies | 4 | 22.2 | - | 1 | 9 | 3 | 13 | 20.0 | 17 | 20.5 | 50–75% |
TOP/stillborn | 16 | 88.9 | 10 | 9 | - | 7 | 26 | 40.0 | 42 | 50.6 | n/a |
Live-births | 2 | 11.1 | 0 | 1 | - | 1 | 2 | 3.1 | 4 | 4.8 | n/a |