Table 2 Genetic findings and outcome of 18 pregnancies complicated by Wolf-Hirschhorn syndrome
From: Prenatal sonographic findings in confirmed cases of Wolf-Hirschhorn syndrome
Case | Fetal karyotype | GA at delivery | Outcome | Fetal weight at birth [g](percentile) | Fetal HC at birth [cm](percentile) |
|---|---|---|---|---|---|
1 | 46,XY, del(4)(p15.2 or p15.3).ish 4(p16.3p16.3)dn(WHS-) | 19 + 0 | TOP | n/a | n/a |
2 | 46,XX, del(4)(p16).ish del(4)(p16.3)(WHS-) | n/a | TOP | n/a | n/a |
3 | 46,XX, del(4)(p15.3) | n/A | TOP | n/a | n/a |
4 | 46,XX, del(4)(p16) | 25 + 3 | TOP | 510 (8.) | 21 (9.) |
5 | 46,XX, del(4)(p15.3) | 33 + 3 | TOP | 1385 (4.) | 24. (< 3.) |
6 | 46,XX, r(4)(p16.3 q35.1–35.2) | 32 + 0 | TOP | 600 (< 3.) | 20 (< 3.) |
7 | 46,XY, del(4)(15.22) | 28 + 2 | TOP | 800 (10.) | 23 (4.) |
8 | 46,XY, ish del(4)(p16.3p16.3)(WHSC1-) | 25 + 6 | TOP | 607 (9.) | 21 (4.) |
9 | 46,XX, del(4)(p15.3) | 30 + 5 | TOP | 1110 (13.) | 26 (10.) |
10 | 46,XY, der(4),t(4;7)(p16.3;q36)pat | 37 + 5 | Live-borna | 1759 (< 3.) | 31 (< 3.) |
11 | 46,XX, del(4)(p15.32) | 28 + 1 | TOP | 750 (12.) | 23 (8.) |
12 | 46,XX, del(4)(p15.2) | 25 + 4 | TOP | 495 (6.) | n/a |
13 | 46,XX, der(4)t(4;13)(p16.1;q14.3)dn | 24 + 6 | TOP | n/a | n/a |
14 | 46,XY, der(4)t(4;7)(p15.2;q32)mat | 20 + 0 | IUD | n/a | n/a |
15 | 46,XX, der(4)t(4;17)(p15.2;q24.3)mat | 24 + 3 | TOP | n/a | n/a |
16 | 46,XX, der(4)t(4;22)(p16.2;q13.31)pat | 20 + 2 | TOP | n/a | n/a |
17 | 46,XX, del(4)(p.15.2) | 29 + 4 | TOP | 990 (17.) | 24 (5.) |
18 | 46,XX, del(4)(p15.?3).ish del(4)(p16.3)(WHSC1-,D4S3360-) | 38 + 4 | Live-born | 2180 (< 3.) | 31 (< 3.) |