Skip to main content

Table 3 Preterm birth and perinatal mortality outcomes, by site

From: The efficacy of low-dose aspirin in pregnancy among women in malaria-endemic countries

Outcome Overall Malaria Negative Malaria positive Aspirin – Malaria Interaction p-value
n/N (%) PR (95% CI) N w/o outcome PR (95% CI) N w/o outcome PR (95% CI)
DRC DRC
 Preterm Delivery
  Aspirin 44/227 (19) 0·98 (0·68, 1·41) 14/87 (16) 1·05 (0·53, 2·10) 30/140 (21) 0·96 (0·62, 1·48) 0.84
  Placebo 48/242 (20)   13/85 (15)   35/157 (22)   
Perinatal Mortality
 Aspirin 18/227 (8) 1·37 (0·70, 2·69) 3/87 (3) 0·42 (0·11, 1·57) 15/140 (11) 2·40 (1·01, 5·72) 0.035
 Placebo 14/242 (6)   7/85 (8)   7/157 (4)   
Kenya
 Preterm Delivery
  Aspirin 29/329 (9) 0·95 (0·58, 1·55) 15/199 (8) 0·94 (0·48, 1·84) 14/130 (11) 0·94 (0·46, 1·92) 0.99
  Placebo 29/313 (9)   16/199 (8)   13/114 (11)   
Perinatal Mortality
 Aspirin 17/329 (5) 0·95 (0·49, 1·83) 7/199 (4) 0·78 (0·30, 2·05) 10/130 (8) 1·10 (0·45, 2·68) 0.62
 Placebo 17/313 (5)   9/199 (5)   8/114 (7)   
Zambia
 Preterm Delivery
 Aspirin 10/168 (6) 0·76 (0·34, 1·70) 9/159 (6) 0·67 (0·30, 1·53) 1/9 (11)
 Placebo 13/167 (8)   13/155 (8)   0/12 (0)   
Perinatal Mortality
 Aspirin 6/168 (4) 0·50 (0·19, 1·29) 6/159 (4) 0·49 (0·19, 1·27) 0/9 (0) 1.00
 Placebo 12/167 (7)   12/155 (8)   0/12 (0)   
  1. Notes: PR is prevalence ratio
  2. PR was not calculated for cells in which no participants experienced the outcome