Characteristics | Age < 35 y (n = 1531) | Age ≥ 35 y (n = 715) | ||||||
---|---|---|---|---|---|---|---|---|
Low AMH (n = 324) | Medium AMH (n = 746) | High AMH (n = 461) | P- value | Low AMH (n = 272) | Medium AMH (n = 343) | High AMH (n = 100) | P- value | |
Stimulation protocol | < 0.0001 | < 0.0001 | ||||||
GnRH agonist | 34.0 (110/324) a | 51.1 (381/746) b | 51.8 (239/461) b | 24.3 (66/272) a | 47.2 (162/343) b | 49.0 (49/100) b | ||
GnRH antagonist | 59.9 (194/324) a | 48.5 (362/746) b | 47.9 (221/461) b | 68.8 (187/272) a | 51.6 (177/343) b | 50.0 (50/100) b | ||
Others | 6.2 (20/324) a | 0.4 (3/746) b | 0.2 (1/461) b | 7.0 (19/272) a | 1.2 (4/343) b | 1.0 (1/100) a, b | ||
Fertilization method | < 0.0001 | 0.028 | ||||||
IVF | 58.0 (188/324) a | 49.7 (371/746) b | 44.3 (204/461) b | 58.1 (158/272) | 53.1 (182/343) | 51.0 (51/100) | ||
ICSI | 41.7 (135/324) a, | 47.7 (356/746) a, b | 50.5 (233/461) a | 41.5 (113/272) | 46.1 (158/343) | 45.0 (45/100) | ||
IVF + ICSI | 0.3 (1/324) a | 2.5 (19/746) b | 5.2 (24/461) c | 0.4 (1/272) a | 0.9 (3/343) a, b | 4.0 (4/100) b | ||
Number of oocytes retrieved | 7 (1–25) a | 12 (1–28) b | 15 (1–34) c | < 0.0001 | 5 (1–23) a | 10 (1–25) b | 13 (4–28) c | < 0.0001 |
Number of mature oocytes | 5 (1–21) a | 10 (1–26) b | 12 (1–29) c | < 0.0001 | 4 (1–19) a | 9 (1–23) b | 11 (2–25) c | < 0.0001 |
Rate of MII (%) | 84.9 (1922/2263) | 83.1 (7516/9046) | 83.1 (5690/6845) | 0.092 | 86.9 (1351/1554) a | 84.6 (3052/3609) a, b | 83.6 (1174/1405) b | 0.026 |
Number of 2PN | 4 (1–17) a | 7 (1–25) b | 9 (1–25) c | < 0.0001 | 3 (0–17) a | 6 (1–16) b | 8 (2–19) c | < 0.0001 |
Normal fertilization rate [% (n/N)] | 70.9 (1454/2052) | 70.7 (5734/8105) | 70.7 (4298/6078) | 0.992 | 71.1 (1011/1422) | 68.7 (2248/3274) | 70.1 (871/1242) | 0.221 |
Normal cleavages of 2PN | 4 (0–17) a | 7 (0–25) b | 9 (1–24) c | < 0.0001 | 3 (0–17) a | 6 (1–16) b | 8 (2–19) c | < 0.0001 |
Cleavage rate (%) | 98.0 (1425/1454) | 97.6 (5596/5734) | 97.8 (4203/4298) | 0.595 | 98.7 (998/1011) | 98.8 (2220/2248) | 97.9 (853/871) | 0.202 |
Number of D3 high-quality embryos | 1 (0–8) a | 2 (0–16) b | 3 (0–15) c | < 0.0001 | 1 (0–14) a | 2 (0–11) b | 3 (0–16) c | < 0.0001 |
High-quality embryo rate [% (n/N)] | 39.3 (560/1425) a, b | 36.7 (2053/5596) b | 39.6 (1664/4203) a | 0.008 | 40.1 (400/998) | 37.8 (840/2220) | 38.7 (330/853) | 0.480 |
Number of embryos transferred | 2 (1–2) a | 2 (1–2) b | 1 (1–2) c | < 0.0001 | 2 (1–3) | 2 (1–3) | 2 (1–3) | 0.058 |
Number of embryos implanted | 0 (0–2) | 0 (0–2) | 0 (0–2) | 0.559 | 0 (0–2) | 0 (0–2) | 0 (0–2) | 0.052 |
Implantation rate [% (n/N)] | 34.5 (193/560) | 35.3 (434/1230) | 37.5 (247/658) | 0.488 | 22.7 (107/471) | 28.3 (167/590) | 23.9 (38/159) | 0.102 |
Pregnancy rate [% (n/N)] | 46.9 (152/324) a | 46.0 (343/746) a | 44.7 (206/461) b | 0.818 | 34.2 (93/272) a | 43.1 (148/343) b | 33.0 (33/100) a | 0.038 |
Biochemical pregnancy rate [% (n/N)] | 4.6 (15/324) a | 4.7 (35/746) b | 3.5 (16/461) a | 0.568 | 3.3 (9/272) | 5.2 (18/343) | 7.0 (7/100) | 0.281 |
Early miscarriage rate [% (n/N)] | 5.6 (18/324) a | 2.5 (19/746) b | 5.4 (25/461) a | 0.015 | 6.6 (18/272) | 8.5 (29/343) | 8.0 (8/100) | 0.692 |
Ectopic pregnancy rate [% (n/N)] | 2.2 (7/324) a | 2.1 (16/746) b | 1.3 (6/461) a | 0.536 | 1.8 (5/272) | 2.0 (7/343) | 1.0 (1/100) | 0.866 |
Live birth rate [% (n/N)] | 37.3 (121/324) | 39.9 (298/746) | 36.0 (166/461) | 0.368 | 22.8 (62/272) | 30.3 (104/343) | 24.0 (24/100) | 0.091 |