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Table 2 The characteristics of the IVF/ICSI treatments and outcomes of the women in the different AMH and age groups

From: Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle

Characteristics

Age < 35 y (n = 1531)

Age ≥ 35 y (n = 715)

Low AMH (n = 324)

Medium AMH (n = 746)

High AMH (n = 461)

P- value

Low AMH (n = 272)

Medium AMH (n = 343)

High AMH (n = 100)

P- value

Stimulation protocol

   

 < 0.0001

   

 < 0.0001

GnRH agonist

34.0 (110/324) a

51.1 (381/746) b

51.8 (239/461) b

 

24.3 (66/272) a

47.2 (162/343) b

49.0 (49/100) b

 

GnRH antagonist

59.9 (194/324) a

48.5 (362/746) b

47.9 (221/461) b

 

68.8 (187/272) a

51.6 (177/343) b

50.0 (50/100) b

 

Others

6.2 (20/324) a

0.4 (3/746) b

0.2 (1/461) b

 

7.0 (19/272) a

1.2 (4/343) b

1.0 (1/100) a, b

 

Fertilization method

   

 < 0.0001

   

0.028

IVF

58.0 (188/324) a

49.7 (371/746) b

44.3 (204/461) b

 

58.1 (158/272)

53.1 (182/343)

51.0 (51/100)

 

ICSI

41.7 (135/324) a,

47.7 (356/746) a, b

50.5 (233/461) a

 

41.5 (113/272)

46.1 (158/343)

45.0 (45/100)

 

IVF + ICSI

0.3 (1/324) a

2.5 (19/746) b

5.2 (24/461) c

 

0.4 (1/272) a

0.9 (3/343) a, b

4.0 (4/100) b

 

Number of oocytes retrieved

7 (1–25) a

12 (1–28) b

15 (1–34) c

 < 0.0001

5 (1–23) a

10 (1–25) b

13 (4–28) c

 < 0.0001

Number of mature oocytes

5 (1–21) a

10 (1–26) b

12 (1–29) c

 < 0.0001

4 (1–19) a

9 (1–23) b

11 (2–25) c

 < 0.0001

Rate of MII (%)

84.9 (1922/2263)

83.1 (7516/9046)

83.1 (5690/6845)

0.092

86.9 (1351/1554) a

84.6 (3052/3609) a, b

83.6 (1174/1405) b

0.026

Number of 2PN

4 (1–17) a

7 (1–25) b

9 (1–25) c

 < 0.0001

3 (0–17) a

6 (1–16) b

8 (2–19) c

 < 0.0001

Normal fertilization rate [% (n/N)]

70.9 (1454/2052)

70.7 (5734/8105)

70.7 (4298/6078)

0.992

71.1 (1011/1422)

68.7 (2248/3274)

70.1 (871/1242)

0.221

Normal cleavages of 2PN

4 (0–17) a

7 (0–25) b

9 (1–24) c

 < 0.0001

3 (0–17) a

6 (1–16) b

8 (2–19) c

 < 0.0001

Cleavage rate (%)

98.0 (1425/1454)

97.6 (5596/5734)

97.8 (4203/4298)

0.595

98.7 (998/1011)

98.8 (2220/2248)

97.9 (853/871)

0.202

Number of D3 high-quality embryos

1 (0–8) a

2 (0–16) b

3 (0–15) c

 < 0.0001

1 (0–14) a

2 (0–11) b

3 (0–16) c

 < 0.0001

High-quality embryo rate [% (n/N)]

39.3 (560/1425) a, b

36.7 (2053/5596) b

39.6 (1664/4203) a

0.008

40.1 (400/998)

37.8 (840/2220)

38.7 (330/853)

0.480

Number of embryos transferred

2 (1–2) a

2 (1–2) b

1 (1–2) c

 < 0.0001

2 (1–3)

2 (1–3)

2 (1–3)

0.058

Number of embryos implanted

0 (0–2)

0 (0–2)

0 (0–2)

0.559

0 (0–2)

0 (0–2)

0 (0–2)

0.052

Implantation rate [% (n/N)]

34.5 (193/560)

35.3 (434/1230)

37.5 (247/658)

0.488

22.7 (107/471)

28.3 (167/590)

23.9 (38/159)

0.102

Pregnancy rate [% (n/N)]

46.9 (152/324) a

46.0 (343/746) a

44.7 (206/461) b

0.818

34.2 (93/272) a

43.1 (148/343) b

33.0 (33/100) a

0.038

Biochemical pregnancy rate [% (n/N)]

4.6 (15/324) a

4.7 (35/746) b

3.5 (16/461) a

0.568

3.3 (9/272)

5.2 (18/343)

7.0 (7/100)

0.281

Early miscarriage rate [% (n/N)]

5.6 (18/324) a

2.5 (19/746) b

5.4 (25/461) a

0.015

6.6 (18/272)

8.5 (29/343)

8.0 (8/100)

0.692

Ectopic pregnancy rate [% (n/N)]

2.2 (7/324) a

2.1 (16/746) b

1.3 (6/461) a

0.536

1.8 (5/272)

2.0 (7/343)

1.0 (1/100)

0.866

Live birth rate [% (n/N)]

37.3 (121/324)

39.9 (298/746)

36.0 (166/461)

0.368

22.8 (62/272)

30.3 (104/343)

24.0 (24/100)

0.091

  1. AMH anti-Müllerian hormone, 2PN 2 pronuclear zygotes
  2. Continuous data are shown as the median (range) and were analysed using the Kruskal–Wallis test
  3. Categorial variables are shown as percentages (number) and were analysed using the chi-square test
  4. The superscripts including the same letter indicate that there was no significant difference among the women with different AMH levels