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Table 2 The characteristics of the IVF/ICSI treatments and outcomes of the women in the different AMH and age groups

From: Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle

Characteristics Age < 35 y (n = 1531) Age ≥ 35 y (n = 715)
Low AMH (n = 324) Medium AMH (n = 746) High AMH (n = 461) P- value Low AMH (n = 272) Medium AMH (n = 343) High AMH (n = 100) P- value
Stimulation protocol      < 0.0001      < 0.0001
GnRH agonist 34.0 (110/324) a 51.1 (381/746) b 51.8 (239/461) b   24.3 (66/272) a 47.2 (162/343) b 49.0 (49/100) b  
GnRH antagonist 59.9 (194/324) a 48.5 (362/746) b 47.9 (221/461) b   68.8 (187/272) a 51.6 (177/343) b 50.0 (50/100) b  
Others 6.2 (20/324) a 0.4 (3/746) b 0.2 (1/461) b   7.0 (19/272) a 1.2 (4/343) b 1.0 (1/100) a, b  
Fertilization method      < 0.0001     0.028
IVF 58.0 (188/324) a 49.7 (371/746) b 44.3 (204/461) b   58.1 (158/272) 53.1 (182/343) 51.0 (51/100)  
ICSI 41.7 (135/324) a, 47.7 (356/746) a, b 50.5 (233/461) a   41.5 (113/272) 46.1 (158/343) 45.0 (45/100)  
IVF + ICSI 0.3 (1/324) a 2.5 (19/746) b 5.2 (24/461) c   0.4 (1/272) a 0.9 (3/343) a, b 4.0 (4/100) b  
Number of oocytes retrieved 7 (1–25) a 12 (1–28) b 15 (1–34) c  < 0.0001 5 (1–23) a 10 (1–25) b 13 (4–28) c  < 0.0001
Number of mature oocytes 5 (1–21) a 10 (1–26) b 12 (1–29) c  < 0.0001 4 (1–19) a 9 (1–23) b 11 (2–25) c  < 0.0001
Rate of MII (%) 84.9 (1922/2263) 83.1 (7516/9046) 83.1 (5690/6845) 0.092 86.9 (1351/1554) a 84.6 (3052/3609) a, b 83.6 (1174/1405) b 0.026
Number of 2PN 4 (1–17) a 7 (1–25) b 9 (1–25) c  < 0.0001 3 (0–17) a 6 (1–16) b 8 (2–19) c  < 0.0001
Normal fertilization rate [% (n/N)] 70.9 (1454/2052) 70.7 (5734/8105) 70.7 (4298/6078) 0.992 71.1 (1011/1422) 68.7 (2248/3274) 70.1 (871/1242) 0.221
Normal cleavages of 2PN 4 (0–17) a 7 (0–25) b 9 (1–24) c  < 0.0001 3 (0–17) a 6 (1–16) b 8 (2–19) c  < 0.0001
Cleavage rate (%) 98.0 (1425/1454) 97.6 (5596/5734) 97.8 (4203/4298) 0.595 98.7 (998/1011) 98.8 (2220/2248) 97.9 (853/871) 0.202
Number of D3 high-quality embryos 1 (0–8) a 2 (0–16) b 3 (0–15) c  < 0.0001 1 (0–14) a 2 (0–11) b 3 (0–16) c  < 0.0001
High-quality embryo rate [% (n/N)] 39.3 (560/1425) a, b 36.7 (2053/5596) b 39.6 (1664/4203) a 0.008 40.1 (400/998) 37.8 (840/2220) 38.7 (330/853) 0.480
Number of embryos transferred 2 (1–2) a 2 (1–2) b 1 (1–2) c  < 0.0001 2 (1–3) 2 (1–3) 2 (1–3) 0.058
Number of embryos implanted 0 (0–2) 0 (0–2) 0 (0–2) 0.559 0 (0–2) 0 (0–2) 0 (0–2) 0.052
Implantation rate [% (n/N)] 34.5 (193/560) 35.3 (434/1230) 37.5 (247/658) 0.488 22.7 (107/471) 28.3 (167/590) 23.9 (38/159) 0.102
Pregnancy rate [% (n/N)] 46.9 (152/324) a 46.0 (343/746) a 44.7 (206/461) b 0.818 34.2 (93/272) a 43.1 (148/343) b 33.0 (33/100) a 0.038
Biochemical pregnancy rate [% (n/N)] 4.6 (15/324) a 4.7 (35/746) b 3.5 (16/461) a 0.568 3.3 (9/272) 5.2 (18/343) 7.0 (7/100) 0.281
Early miscarriage rate [% (n/N)] 5.6 (18/324) a 2.5 (19/746) b 5.4 (25/461) a 0.015 6.6 (18/272) 8.5 (29/343) 8.0 (8/100) 0.692
Ectopic pregnancy rate [% (n/N)] 2.2 (7/324) a 2.1 (16/746) b 1.3 (6/461) a 0.536 1.8 (5/272) 2.0 (7/343) 1.0 (1/100) 0.866
Live birth rate [% (n/N)] 37.3 (121/324) 39.9 (298/746) 36.0 (166/461) 0.368 22.8 (62/272) 30.3 (104/343) 24.0 (24/100) 0.091
  1. AMH anti-Müllerian hormone, 2PN 2 pronuclear zygotes
  2. Continuous data are shown as the median (range) and were analysed using the Kruskal–Wallis test
  3. Categorial variables are shown as percentages (number) and were analysed using the chi-square test
  4. The superscripts including the same letter indicate that there was no significant difference among the women with different AMH levels