TABLE 1 Baseline characteristics of training and validation cohort
Training cohort (n = 1233) | Validation cohort (n = 312) | P-value | |
|---|---|---|---|
Female age (y) | 30.40 ± 4.06 | 30.39 ± 4.29 | 0.980 |
Male age (y) | 31.89 ± 4.68 | 31.80 ± 4.55 | 0.756 |
Infertility duration (y) | 2.36 ± 2.18 | 2.48 ± 2.36 | 0.393 |
Infertility type | 0.933 | ||
Primary infertility | 422 (34.23%) | 106 (33.97%) | |
Secondary infertility | 811 (65.77%) | 206 (66.03%) | |
AFC (n) | 13.70 ± 5.42 | 13.03 ± 5.15 | 0.049 |
Chromosomal abnormality | 354 (28.71%) | 78 (25.00%) | 0.192 |
FORT (%) | 87.24 | 83.84 | 0.415 |
FOI (%) | 74.83 | 73.48 | 0.892 |
MII oocyte rate (%) | 74.28 | 76.43 | 0.226 |
Cleavage rate (%) | 80.03 | 81.19 | 0.193 |
2PN rate (%) | 78.32 | 79.39 | 0.115 |
Blastocyst formation rate (%) | 64.34 | 64.73 | 0.987 |
Gn dosage (IU) | 2203.78 ± 750.40 | 2276.20 ± 833.32 | 0.137 |
Gn duration (days) | 10.31 ± 1.82 | 10.30 ± 1.67 | 0.890 |
Euploid rate (%) | 513 (41.61%) | 128 (41.03%) | 0.853 |
No. of day3 cells | 8.08 ± 1.56 | 8.21 ± 1.66 | 0.188 |
Uneven cleavage embryos | 501 (40.63%) | 106 (33.97%) | 0.031 |
Embryo fragmentation of D3 | 0.517 | ||
0 | 513 (41.61%) | 141 (45.19%) | |
5–10 | 466 (37.79%) | 110 (35.26%) | |
> 10 | 254 (20.60%) | 61 (19.55%) | |
Timing of embryo biopsy | 0.630 | ||
D5 AM | 701 (56.85%) | 174 (55.77%) | |
D5 PM | 325 (26.36%) | 90 (28.85%) | |
D6 | 207 (16.79%) | 48 (15.38%) | |
Expansion degree of D5 | 0.554 | ||
2 | 7 (0.57%) | 2 (0.64%) | |
3 | 299 (24.25%) | 75 (24.04%) | |
4 | 893 (72.42%) | 227 (72.76%) | |
5 | 24 (1.95%) | 3 (0.96%) | |
6 | 10 (0.81%) | 5 (1.60%) | |
Inner cell mass of D5 | 0.064 | ||
A | 9 (0.73%) | 3 (0.96%) | |
B | 832 (67.48%) | 231 (74.04%) | |
C | 392 (31.79%) | 78 (25.00%) | |
Trophectoderm grade of D5 | 0.930 | ||
A | 6 (0.49%) | 2 (0.64%) | |
B | 358 (29.03%) | 92 (29.49%) | |
C | 869 (70.48%) | 218 (69.87%) | |