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Table 2 Cord blood metabolites with altered abundances induced by anti-thyroid antibodies positivity

From: Cord blood metabolomics reveals gestational metabolic disorder associated with anti-thyroid peroxidase antibodies positivity

Metabolite

Chemical shift

anti-TPO/Control

VIP

P(corr)

FC

p-value

FDR-adjusted

p-value

L-Leucine

0.948t, 1.700 m, 3.722 m

1.01

-0.42

0.06

 < 0.01

 < 0.01

L-Lysine

1.46 m, 1.71 m, 1.89 m, 3.02t, 3.74t

1.35

-0.55

0.18

 < 0.01

 < 0.05

D-Glucose

3.233dd, 3.398 m, 3.458 m, 3.524dd,

3.728 m, 3.824 m, 3.889dd, 4.634d, 5.223d

5.51

0.63

2.09

 < 0.01

 < 0.01

Creatinine

3.03 s, 4.05 s

1.02

0.59

2.10

 < 0.01

 < 0.01

Myo-Inositol

3.268t, 3.524dd, 3.613t, 4.053t

1.17

0.53

4.61

 < 0.01

 < 0.01

3-Hydroxybutyric acid

1.204d, 2.314dd, 2.414dd, 4.160 m

3.44

0.81

2.05

 < 0.01

 < 0.05

L-Glutamic acid

2.040 m, 2.119 m, 2.341 m, 3.748dd

1.92

-0.76

0.14

 < 0.05

 < 0.05

L-Glutamine

2.125 m, 2.446 m, 3.766t

2.48

0.66

5.82

 < 0.01

 < 0.05

L-Tyrosine

3.024dd, 3.170dd, 3.921dd, 6.877 m, 7.170 m

1.49

-0.69

0.35

 < 0.01

 < 0.05

L-Phenylalanine

3.19 m, 3.98dd, 7.32d, 7.36 m, 7.42 m

1.46

-0.64

0.16

 < 0.01

 < 0.01

  1. VIP Variable Importance in the projection, FDR false discovery rate, p(corr) spearman rank correlation coefficient calculated with the principle component 1 of the selected OPLS-DA model, FC Fold change, s single peak, d double peaks, t triplet peaks, q quarter peaks, m multiple peaks