Fig. 1
PCA and OPLS-DA on the cord blood metabolome between pregnant women with anti-TPO antibodies positivity and the nested control. a PCA score plot based on the first two principle components (PCs), which explain 27% of the total variations (16.1% and 10.9% for PC1 and PC 2, respectively). b OPLS-DA score plot of the cord blood metabolome. The horizontal axis represents the predicted score of the first component, which explained 13% of the between-group variations. The vertical axis represents the orthogonal principle components score, which explained 29.1% of the within-group variations. The ellipse represents the 95% confidence interval using Hotelling’s T2 statistics. PCA: Principle Component Analysis. OPLS-DA: Orthogonal Partial Least Squares- Discriminant Analysis. anti-TPO: Anti-thyroid peroxidase