Table 1 Distributions of 488 CNS anomalies in 365 fetuses
Types of CNS anomalies | Isolated CNS anomaly | Â | Multiple system anomalies (n, %) | Total (n, %) |
|---|---|---|---|---|
| Â | Single CNS anomaly (n, %) | Multiple CNS anomaly (n, %) | Â | Â |
Neural tube defect | ||||
 - Anencephaly | 36 (7.38) | 1 (0.20) | 4 (0.82) | 41 (8.40) |
 - Encephalocele | 9 (1.84) | 6 (1.23) | 9 (1.84) | 24 (4.92) |
 -Meningocele | 1 (0.20) | - | - | 1 (0.20) |
 -Myelomeningocele | 1 (0.20) | 9 (1.84) | 8 (1.64) | 18 (3.69) |
 -Spina bifida occulta | - | - | 1 (0.20) | 1 (0.20) |
 -Unclassified closed spina bifida | 1 (0.20) | - | - | 1 (0.20) |
 -Unclassified NTD | 1 (0.20) | 6 (1.23) | 5 (1.02) | 12 (2.46) |
Ventriculomegaly | 29 (5.94) | 24 (4.92) | 61 (12.50) | 114 (23.36) |
Holoprosencephaly | 5 (1.02) | 1 (0.20) | 29 (5.94) | 35 (7.17) |
Microcephaly | - | 2 (0.41) | 12 (2.46) | 14 (2.87) |
Cysts | ||||
 - arachnoid cyst | 4 (0.82) | - | 3 (0.61) | 7 (1.43) |
 - choroid plexus cyst | 1 (0.20) | - | 10 (2.05) | 11 (2.25) |
Cystic hygroma | - | 8 (1.64) | 10 (2.05) | 60 (12.30) |
Chiari Type II malformation | - | - | 2 (0.41) | 18 (3.69) |
Dandy Walker malformation | 4 (0.82) | 1 (0.20) | 17 (3.48) | 22 (4.51) |
Cerebellar disorder | - | 5 (1.02) | 14 (2.87) | 19 (3.89) |
Megacisterna magna | 1 (0.20) | 4 (0.82) | 18 (3.69) | 23 (4.71) |
Agenesis of corpus callosum | - | 3 (0.61) | 13 (2.66) | 16 (3.28) |
Other spinal malformations | 4 (0.82) | 1 (0.20) | 24 (4.92) | 29 (5.94) |
Miscellaneous | ||||
 -sacrococcygeal teratoma | 4 (0.82) | - | 1 (0.20) | 5 (1.02) |
 -cerebral atrophy | - | - | 2 (0.41) | 2 (0.41) |
 -wide CSP | - | - | 3 (0.61) | 3 (0.61) |
 -absent CSP | - | 3 (0.61) | 5 (1.02) | 8 (1.64) |
 -megalencephaly | - | - | 1 (0.20) | 1 (0.20) |
 -hydranencephaly | - | - | 1 (0.20) | 1 (0.20) |
 -intracranial haemorrhage | - | 1 (0.20) | - | 1 (0.20) |
- intracranial tumour | 1 (0.20) | - | - | 1 (0.20) |