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Table 1 Distributions of 488 CNS anomalies in 365 fetuses

From: Evaluation of prenatal central nervous system anomalies: obstetric management, fetal outcomes and chromosome abnormalities

Types of CNS anomalies Isolated CNS anomaly   Multiple system anomalies (n, %) Total (n, %)
  Single CNS anomaly (n, %) Multiple CNS anomaly (n, %)   
Neural tube defect
 - Anencephaly 36 (7.38) 1 (0.20) 4 (0.82) 41 (8.40)
 - Encephalocele 9 (1.84) 6 (1.23) 9 (1.84) 24 (4.92)
 -Meningocele 1 (0.20) - - 1 (0.20)
 -Myelomeningocele 1 (0.20) 9 (1.84) 8 (1.64) 18 (3.69)
 -Spina bifida occulta - - 1 (0.20) 1 (0.20)
 -Unclassified closed spina bifida 1 (0.20) - - 1 (0.20)
 -Unclassified NTD 1 (0.20) 6 (1.23) 5 (1.02) 12 (2.46)
Ventriculomegaly 29 (5.94) 24 (4.92) 61 (12.50) 114 (23.36)
Holoprosencephaly 5 (1.02) 1 (0.20) 29 (5.94) 35 (7.17)
Microcephaly - 2 (0.41) 12 (2.46) 14 (2.87)
Cysts
 - arachnoid cyst 4 (0.82) - 3 (0.61) 7 (1.43)
 - choroid plexus cyst 1 (0.20) - 10 (2.05) 11 (2.25)
Cystic hygroma - 8 (1.64) 10 (2.05) 60 (12.30)
Chiari Type II malformation - - 2 (0.41) 18 (3.69)
Dandy Walker malformation 4 (0.82) 1 (0.20) 17 (3.48) 22 (4.51)
Cerebellar disorder - 5 (1.02) 14 (2.87) 19 (3.89)
Megacisterna magna 1 (0.20) 4 (0.82) 18 (3.69) 23 (4.71)
Agenesis of corpus callosum - 3 (0.61) 13 (2.66) 16 (3.28)
Other spinal malformations 4 (0.82) 1 (0.20) 24 (4.92) 29 (5.94)
Miscellaneous
 -sacrococcygeal teratoma 4 (0.82) - 1 (0.20) 5 (1.02)
 -cerebral atrophy - - 2 (0.41) 2 (0.41)
 -wide CSP - - 3 (0.61) 3 (0.61)
 -absent CSP - 3 (0.61) 5 (1.02) 8 (1.64)
 -megalencephaly - - 1 (0.20) 1 (0.20)
 -hydranencephaly - - 1 (0.20) 1 (0.20)
 -intracranial haemorrhage - 1 (0.20) - 1 (0.20)
- intracranial tumour 1 (0.20) - - 1 (0.20)