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Table 4 Crude and adjusted odds ratios of pregnancy outcomes in blastomere number categories

From: Increased blastomere number is associated with higher live birth rate in day 3 embryo transfer

 

 ≤ 6-cell

7-cell

8-cell

9-cell

10-cell

 ≥ 11-cell

Positive hCG test

 Crude OR (95% CI)

0.30 (0.19–0.47)

0.51 (0.38–0.68)

Reference

0.68 (0.50–0.92)

1.25 (0.81–1.93)

1.56 (1.06–2.29)

P-value

 < 0.001

 < 0.001

-

0.012

0.320

0.023

 Adjusted OR (95% CI)

0.43 (0.27–0.68)

0.67 (0.49–0.93)

Reference

0.84 (0.60–1.18)

1.65 (1.04–2.61)

1.77 (1.19–2.63)

P-value

 < 0.001

0.018

-

0.322

0.032

0.005

Clinical pregnancy

 Crude OR (95% CI)

0.33 (0.21–0.53)

0.5 (0.37–0.68)

Reference

0.66 (0.48–0.90)

1.22 (0.80–1.87)

1.85 (1.28–2.69)

P-value

 < 0.001

 < 0.001

-

0.008

0.349

0.001

 Adjusted OR (95% CI)

0.46 (0.28–0.76)

0.65 (0.46–0.91)

Reference

0.8 (0.56–1.13)

1.58 (1.02–2.46)

2.11 (1.44–3.10)

P-value

0.002

0.012

-

0.201

0.042

 < 0.001

Miscarriage

 Crude OR (95% CI)

1.04 (0.38–2.83)

0.78 (0.40–1.51)

Reference

0.79 (0.41–1.51)

0.89 (0.42–1.88)

0.73 (0.40–1.35)

P-value

0.938

0.458

-

0.476

0.758

0.322

 Adjusted OR (95% CI)

0.87 (0.27–2.86)

0.59 (0.29–1.20)

Reference

0.59 (0.29–1.20)

0.72 (0.34–1.54)

0.64 (0.33–1.24)

P-value

0.824

0.148

-

0.143

0.400

0.183

Live birth

 Crude OR (95% CI)

0.37 (0.22–0.61)

0.58 (0.42–0.81)

Reference

0.74 (0.54–1.03)

1.23 (0.80–1.89)

1.83 (1.28–2.62)

P-value

 < 0.001

0.001

-

0.072

0.336

 < 0.001

 Adjusted OR (95% CI)

0.50 (0.29–0.86)

0.74 (0.52–1.06)

Reference

0.91 (0.63–1.32)

1.62 (1.03–2.53)

2.14 (1.47–3.11)

P-value

0.013

0.106

-

0.630

0.035

 < 0.001

  1. Adjusted for maternal age and BMI, infertility duration, infertility type, infertility diseases, IVF failure history, total gonadotropin dose, trigger day E2 level, P level and endometrial thickness, number of oocytes retrieved, fertilization method, fragmentation percentage, blastomere symmetry, and presence of multinucleation or vacuoles
  2. OR odds ratio, CI confidence interval, hCG human chorionic gonadotropin