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Table 1 Biochemical and clinical characteristics of total patients according to AMH group

From: Association of antimüllerian hormone with polycystic ovarian syndrome phenotypes and pregnancy outcomes of in vitro fertilization cycles with fresh embryo transfer

Maternal characteristics

Serum AMH, ng/mL

P-value

 ≤ 2.25 (n = 746)

2.25–5.71 (n = 1486)

 > 5.71 (n = 741)

Female age (y)

33.0 (30.0–36.0)a,b

31.0 (29.0–34.0)b

31.0 (28.0–33.0)

 < 0.0011

Female BMI (kg/m2)

21.1 (19.5–22.8)

21.1 (19.5–23.1)

21.1 (19.5–23.4)

0.6041

Type of infertility

   

 < 0.0012

 Primary

337 (45.2%)b

750 (50.5%)

411 (55.5%)

 

 Secondary

409 (54.8%)

736 (49.5%)

330 (44.5%)

 

Duration of infertility (y)

3.0 (1.5–5.0)

3.0 (2.0–5.0)

3.0 (2.0–5.0)

0.3071

Cause of infertility

 Uterine and tubal factor

287 (38.5%)b

559 (37.6%)b

210 (28.3%)

 < 0.0012

 Ovulatory disorders

4 (0.5%)a,b

51 (3.4%)b

159 (21.5%)

 < 0.0012

 Endometriosis

65 (8.7%)

109 (7.3%)

42 (5.7%)

0.0772

 Male factor

113 (15.1%)

228 (15.3%)

103 (13.9%)

0.6552

 Female and male factor

64 (8.6%)

158 (10.6%)

92 (12.4%)

0.0552

 Unexplained

213 (28.6%)b

381 (25.6%)b

135 (18.2%)

 < 0.0012

D3 serum FSH level (IU/L)

6.62 (5.05–7.82)c

6.44 (5.39–7.53)c

5.83 (4.22–8.34)

0.0131

D3 serum LH level (IU/L)

3.87 (2.85–5.16)a,b

4.62 (3.43–6.17)b

6.20 (5.34–7.21)

 < 0.0011

LH/FSH ratio

0.61 (0.45–0.81)a,b

0.72 (0.55–0.95)b

0.92 (0.72–1.33)

 < 0.0011

Testosterone(ng/ml)

0.23 (0.15–0.32)a,b

0.25 (0.18–0.33)b

0.30 (0.22–0.40)

 < 0.0011

TSH (μIU/mL)

1.92 (1.40–2.69)

1.95 (1.38–2.69)

2.01 (1.44–3.01)

0.0431

Fasting glucose (mmol/L)

5.19 (4.85–5.67)

5.25 (4.95–5.56)

5.25 (4.94–5.63)

0.7441

Fasting insulin (μU/mL)

9.90 (6.60–17.50)

10.40 (7.28–15.65)

10.50 (7.30–15.35)

0.9471

QUICKI

0.336 ± 0.033

0.334 ± 0.032

0.334 ± 0.030

0.8463

Hyperandrogenemia, %

58 (7.8%)b

127 (8.5%)b

106 (14.3%)

 < 0.0012

Polycystic ovaries, %

8 (1.1%)a,b

108 (7.3%)b

267 (36.0%)

 < 0.0012

Menstrual regularity

   

 < 0.0012

 Regular periods, %

606 (81.2%)a,b

974 (65.5%)b

298 (40.2%)

 

 Oligomenorrhea, %

138 (18.5%)a,b

495 (33.3%)b

385 (52.0%)

 

 Amenorrhea, %

2 (0.3%)b

17 (1.1%)b

58 (7.8%)

 

PCOS diagnosis, %

16 (2.1%)a,b

134 (9.0%)b

268 (36.2%)

 < 0.0012

Gonadotropin start dose(IU)

300.0 (225.0–300.0)a,b

225.0 (150.0–300.0)b

150.0 (112.5–225.0)

 < 0.0011

Duration of gonadotropin stimulation (d)

9.0 (8.0–11.0)

9.0 (8.0–10.0)

9.0 (8.0–10.0)

0.0411

Total dose of gonadotropin used (IU)

2700.0 (2287.5–3000.0)a,b

2400.0 (1837.5–2756.4)b

1800.0 (1350.0–2262.4)

 < 0.0011

Serum E2 level (pg/mL) on hCG day

1886.0 (1342.0–2523.5)a,b

2601.0 (1924.8–3765.8)b

2912.0 (2223.0–4134.5)

 < 0.0011

Endometrial thickness (mm) on hCG day

11 (10–13)

11 (10–13)

11 (10–12)

0.5301

No. of oocyte retrieved

9 (7–12)a,b

12 (10–15)b

14 (11–16)

 < 0.0011

No. of oocyte fertilized

7 (5–10)a,b

10 (7–13)b

11 (9–14)

 < 0.0011

No. of embryos transferred

2.02 ± 0.61a

1.92 ± 0.55

1.95 ± 0.45

0.0011

Cycles with different technologies

  

0.0562

 IVF

634 (85.0%)

1242 (83.6%)

648 (87.4%)

 

 ICSI

112 (15.0%)

244 (16.4%)

93 (12.6%)

 

Embryo type

   

 < 0.0012

 Cleavage embryo

509 (68.2%)a,b

847 (57.0%)

457 (61.7%)

 

 Blastocyst

237 (31.8%)

639 (43.0%)

284 (38.3%)

 

Embryo quality

   

0.0032

 Cycle with high-quality embryos

701 (94.0%)d

1412 (95.0%)d

723 (97.6%)

 

 Cycles without high-quality embryos

45 (6.0%)

74 (5.0%)

18 (2.4%)

 
  1. Note: BMI Body mass index, FSH Follicle-stimulating hormone, LH Luteinizing hormone, TSH Thyroid-stimulating hormone, QUICKI Quantitative insulin sensitivity check index, E2 Estradiol, IVF in vitro fertilization, ICSI Intracytoplasmic sperm injection, hCG human chorionic gonadotropin
  2. Values are numbers (percentages) of participants, median (interquartile range) or mean ± standard deviation
  3. 1Kruskal-Wallis test followed by a post-hoc pairwise comparison
  4. 2Chi-square test followed by Bonferroni post-hoc test
  5. 3One-way ANOVA followed by Bonferroni post-hoc test
  6. aP < 0.001, statistically significant differences from average-AMH group
  7. bP < 0.001, statistically significant differences from high-AMH group
  8. cP < 0.05, statistically significant differences from high-AMH group
  9. dP < 0.01, statistically significant differences from high-AMH group