Maternal characteristics | Serum AMH, ng/mL | P-value | ||
---|---|---|---|---|
≤ 2.25 (n = 746) | 2.25–5.71 (n = 1486) | > 5.71 (n = 741) | ||
Female age (y) | 33.0 (30.0–36.0)a,b | 31.0 (29.0–34.0)b | 31.0 (28.0–33.0) | < 0.0011 |
Female BMI (kg/m2) | 21.1 (19.5–22.8) | 21.1 (19.5–23.1) | 21.1 (19.5–23.4) | 0.6041 |
Type of infertility | < 0.0012 | |||
Primary | 337 (45.2%)b | 750 (50.5%) | 411 (55.5%) | |
Secondary | 409 (54.8%) | 736 (49.5%) | 330 (44.5%) | |
Duration of infertility (y) | 3.0 (1.5–5.0) | 3.0 (2.0–5.0) | 3.0 (2.0–5.0) | 0.3071 |
Cause of infertility | ||||
Uterine and tubal factor | 287 (38.5%)b | 559 (37.6%)b | 210 (28.3%) | < 0.0012 |
Ovulatory disorders | 4 (0.5%)a,b | 51 (3.4%)b | 159 (21.5%) | < 0.0012 |
Endometriosis | 65 (8.7%) | 109 (7.3%) | 42 (5.7%) | 0.0772 |
Male factor | 113 (15.1%) | 228 (15.3%) | 103 (13.9%) | 0.6552 |
Female and male factor | 64 (8.6%) | 158 (10.6%) | 92 (12.4%) | 0.0552 |
Unexplained | 213 (28.6%)b | 381 (25.6%)b | 135 (18.2%) | < 0.0012 |
D3 serum FSH level (IU/L) | 6.62 (5.05–7.82)c | 6.44 (5.39–7.53)c | 5.83 (4.22–8.34) | 0.0131 |
D3 serum LH level (IU/L) | 3.87 (2.85–5.16)a,b | 4.62 (3.43–6.17)b | 6.20 (5.34–7.21) | < 0.0011 |
LH/FSH ratio | 0.61 (0.45–0.81)a,b | 0.72 (0.55–0.95)b | 0.92 (0.72–1.33) | < 0.0011 |
Testosterone(ng/ml) | 0.23 (0.15–0.32)a,b | 0.25 (0.18–0.33)b | 0.30 (0.22–0.40) | < 0.0011 |
TSH (μIU/mL) | 1.92 (1.40–2.69) | 1.95 (1.38–2.69) | 2.01 (1.44–3.01) | 0.0431 |
Fasting glucose (mmol/L) | 5.19 (4.85–5.67) | 5.25 (4.95–5.56) | 5.25 (4.94–5.63) | 0.7441 |
Fasting insulin (μU/mL) | 9.90 (6.60–17.50) | 10.40 (7.28–15.65) | 10.50 (7.30–15.35) | 0.9471 |
QUICKI | 0.336 ± 0.033 | 0.334 ± 0.032 | 0.334 ± 0.030 | 0.8463 |
Hyperandrogenemia, % | 58 (7.8%)b | 127 (8.5%)b | 106 (14.3%) | < 0.0012 |
Polycystic ovaries, % | 8 (1.1%)a,b | 108 (7.3%)b | 267 (36.0%) | < 0.0012 |
Menstrual regularity | < 0.0012 | |||
Regular periods, % | 606 (81.2%)a,b | 974 (65.5%)b | 298 (40.2%) | |
Oligomenorrhea, % | 138 (18.5%)a,b | 495 (33.3%)b | 385 (52.0%) | |
Amenorrhea, % | 2 (0.3%)b | 17 (1.1%)b | 58 (7.8%) | |
PCOS diagnosis, % | 16 (2.1%)a,b | 134 (9.0%)b | 268 (36.2%) | < 0.0012 |
Gonadotropin start dose(IU) | 300.0 (225.0–300.0)a,b | 225.0 (150.0–300.0)b | 150.0 (112.5–225.0) | < 0.0011 |
Duration of gonadotropin stimulation (d) | 9.0 (8.0–11.0) | 9.0 (8.0–10.0) | 9.0 (8.0–10.0) | 0.0411 |
Total dose of gonadotropin used (IU) | 2700.0 (2287.5–3000.0)a,b | 2400.0 (1837.5–2756.4)b | 1800.0 (1350.0–2262.4) | < 0.0011 |
Serum E2 level (pg/mL) on hCG day | 1886.0 (1342.0–2523.5)a,b | 2601.0 (1924.8–3765.8)b | 2912.0 (2223.0–4134.5) | < 0.0011 |
Endometrial thickness (mm) on hCG day | 11 (10–13) | 11 (10–13) | 11 (10–12) | 0.5301 |
No. of oocyte retrieved | 9 (7–12)a,b | 12 (10–15)b | 14 (11–16) | < 0.0011 |
No. of oocyte fertilized | 7 (5–10)a,b | 10 (7–13)b | 11 (9–14) | < 0.0011 |
No. of embryos transferred | 2.02 ± 0.61a | 1.92 ± 0.55 | 1.95 ± 0.45 | 0.0011 |
Cycles with different technologies | 0.0562 | |||
IVF | 634 (85.0%) | 1242 (83.6%) | 648 (87.4%) | |
ICSI | 112 (15.0%) | 244 (16.4%) | 93 (12.6%) | |
Embryo type | < 0.0012 | |||
Cleavage embryo | 509 (68.2%)a,b | 847 (57.0%) | 457 (61.7%) | |
Blastocyst | 237 (31.8%) | 639 (43.0%) | 284 (38.3%) | |
Embryo quality | 0.0032 | |||
Cycle with high-quality embryos | 701 (94.0%)d | 1412 (95.0%)d | 723 (97.6%) | |
Cycles without high-quality embryos | 45 (6.0%) | 74 (5.0%) | 18 (2.4%) |