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Table 5 The positive and negative likelihood ratios using maternal characteristics and different serum marker combinations

From: Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia

Marker

Preeclampsia

Gestational hypertension

Preterm birth

All

Preterm

Early-onset

LR + (CI)

LR- (CI)

LR + (CI)

LR- (CI)

LR + (CI)

LR- (CI)

LR + (CI)

LR- (CI)

LR + (CI)

LR- (CI)

T1 Biochemical Markersa

 5% FPR

4.53

(3.14,6.53)

0.81

(0.74,0.89)

4.95

(2.91,8.42)

0.79

(0.67,0.93)

6.99

(3.56,13.73)

0.68

(0.48,0.97)

2.66

(1.86,3.81)

0.91

(0.87,0.96)

3.40

(2.29,5.08)

0.87

(0.81,0.94)

 10% FPR

3.27

(2.49,4.31)

0.75

(0.66,0.84)

4.15

(2.89,5.97)

0.65

(0.51,0.82)

3.52

(1.82,6.79)

0.72

(0.51,1.02)

1.94

(1.47,2.55)

0.90

(0.84,0.95)

2.47

(1.82,3.34)

0.84

(0.76,0.92)

 20% FPR

2.75

(2.30,3.28)

0.56

(0.47,0.68)

3.64

(2.92,4.32)

0.34

(0.21,0.54)

3.23

(2.25,4.65)

0.44

(0.23,0.84)

1.77

(1.47,2.12)

0.81

(0.74,0.88)

2.00

(1.62,2.48)

0.75

(0.66,0.85)

T2 Biochemical Markersb

 5% FPR

4.53

(2.72,7.55)

0.81

(0.72,0.92)

5.83

(2.93,11.61)

0.75

(0.58,0.96)

10.00

(4.72,21.20)

0.53

(0.26,1.05)

2.40

(1.43,4.24)

0.92

(0.86,0.99)

3.74

(2.12,6.59)

0.85

(0.76,0.96)

 10% FPR

3.07

(2.06,4.55)

0.77

(0.66,0.90)

4.17

(2.49,6.97)

0.65

(0.46,0.91)

6.25

(3.52,11.09)

0.42

(0.17,1.02)

2.00

(1.34,2.98)

0.89

(0.81,0.97)

2.84

(1.87,4.32)

0.79

(0.67,0.92)

 20% FPR

2.20

(1.65,2.94)

0.70

(0.57,0.86)

2.92

(2.03,4.20)

0.52

(0.32,0.84)

4.38

(3.26,5.87)

0.16

(0.03,0.98)

1.42

(1.05,1.93)

0.89

(0.80,1.00)

1.86

(1.34,2.58)

0.78

(0.64,0.94)

Maternal Characteristics Only

 5% FPR

3.63

(2.42,5.44)

0.86

(0.80,0.93)

2.98

(1.46,6.08)

0.90

(0.80,1.01)

3.53

(1.23,10.05)

0.87

(0.70,1.08)

4.40

(3.26,5.95)

0.82

(0.77,0.88)

1.47

(0.80,2.68)

0.98

(0.93,1.02)

 10% FPR

3.08

(2.32,4.08)

0.77

(0.69,0.86)

2.98

(1.88,4.72)

0.78

(0.65,0.94)

1.78

(0.63,5.03)

0.91

(0.73,1.14)

3.43

(2.76,4.25)

0.73

(0.67,0.80)

1.53

(1.03,2.29)

0.94

(0.88,1.01)

 20% FPR

2.24

(1.82,2.75)

0.69

(0.60,0.80)

2.34

(1.70,3.22)

0.67

(0.51,0.87)

2.04

(1.15,3.63)

0.74

(0.50,1.10)

2.71

(2.34,3.12)

0.57

(0.50,0.65)

1.27

(0.95,1.69)

0.93

(0.85,1.03)

Maternal Characteristicsc + T1 PlGF + T1 PAPP-A

 5% FPR

5.96

(4.28,8.29)

0.74

(0.66,0.82)

6.92

(4.43,10.83)

0.69

(0.56,0.85)

8.20

(4.48,15.01)

0.62

(0.42,0.92)

4.64

(3.43,6.27)

0.81

(0.76,0.86)

3.00

(1.94,4.65)

0.89

(0.83,0.96)

 10% FPR

4.14

(3.24,5.29)

0.65

(0.56,0.75)

5.19

(3.80,7.09)

0.53

(0.39,0.72)

6.44

(4.41,9.41)

0.39

(0.21,0.75)

3.93

(3.20,4.83)

0.67

(0.61,0.74)

2.11

(1.50,2.98)

0.88

(0.80,0.95)

 20% FPR

2.98

(2.52,3.52)

0.50

(0.41,0.62)

3.36

(2.69,4.20)

0.41

(0.27,0.62)

3.80

(2.88,5.04)

0.29

(0.13,0.69)

2.89

(2.51,3.33)

0.53

(0.46,0.61)

1.81

(1.43,2.29)

0.80

(0.70,0.90)

Maternal Characteristicsc + All T1 Biomarkersa

 5% FPR

5.96

(4.28,8.29)

0.74

(0.66,0.82)

7.36

(4.78,11.32)

0.66

(0.53,0.83)

9.37

(5.44,16.16)

0.56

(0.36,0.87)

4.71

(3.49,6.36)

0.80

(0.75,0.86)

3.82

(2.58,5.65)

0.85

(0.79,0.92)

 10% FPR

4.50

(3.57,5.69)

0.61

(0.52,0.71)

5.84

(4.41,7.74)

0.46

(0.33,0.65)

7.03

(5.01,9.86)

0.33

(0.16,0.68)

4.00

(3.26,4.91)

0.66

(0.60,0.73)

2.87

(2.14,3.84)

0.79

(0.71,0.88)

 20% FPR

2.95

(2.49,3.49)

0.51

(0.42,0.63)

3.58

(2.92,4.40)

0.35

(0.22,0.56)

4.11

(3.24,5.23)

0.22

(0.08,0.62)

2.93

(2.55,3.36)

0.52

(0.45,0.60)

1.98

(1.59,2.48)

0.75

(0.66,0.86)

Maternal Characteristicsc + All T2 Biomarkersb

 5% FPR

5.46

(3.39,8.81)

0.76

(0.66,0.88)

7.80

(4.32,14.08)

0.64

(0.46,0.89)

14.86

(9.04,24.42)

0.26

(0.08,0.87)

5.79

(3.84,8.74)

0.75

(0.66,0.84)

3.48

(1.84,6.56)

0.87

(0.77,0.98)

 10% FPR

3.82

(2.68,5.46)

0.69

(0.57,0.82)

4.77

(2.97,7.66)

0.58

(0.39,0.86)

7.43

(4.74,11.63)

0.28

(0.08,0.92)

4.00

(2.96,5.41)

0.67

(0.57,0.77)

3.65

(2.46,5.42)

0.70

(0.58,0.86)

 20% FPR

3.14

(2.51,3.92)

0.46

(0.34,0.63)

3.25

(2.34,4.51)

0.44

(0.25,0.76)

3.73

(2.45,5.70)

0.31

(0.09,1.04)

2.81

(2.28,3.47)

0.55

(0.44,0.67)

2.88

(2.23,3.74)

0.53

(0.39,0.72)

  1. LR ( +) Positive Likelihood Ratio, LR (-): Negative Likelihood Ratio, CI 95% confidence Interval
  2. aFirst Trimester (T1) Biochemical Markers: PAPP-A, free-β hCG,PlGF, AFP, Inhibin A. Refer to Table 3 for specific markers used in each case group
  3. bSecond Trimester (T2) Biochemical Markers: AFP, uE3, hCG, PAPP-A, PlGF. Refer to Table 3 for specific markers used in each case group
  4. cSignificant maternal characteristics for each case group include- All PE: age, weight, ethnicity, nulliparous; Preterm PE: age, weight, ethnicity, gravidity; Early-onset PE: age, gravidity; Gestational Hypertension: age, weight, ethnicity, nulliparous; Preterm Birth: nulliparous
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BMC Pregnancy and Childbirth

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