Table 4 Model-predicted screening performance using maternal characteristics and different serum marker combinations
From: Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia
Marker | Preeclampsia | Gestational hypertension | Preterm birth | ||
|---|---|---|---|---|---|
All | Preterm | Early-onset | |||
T1 Biochemical Markers a | |||||
 AUC | 0.70 (0.654,0.753) | 0.80 (0.734,0.867) | 0.76 (0.635,0.890) | 0.63 (0.593,0.663) | 0.64 (0.588,0.685) |
 DR% (CI) for 5% FPR | 23 (15.9,29.8) | 25 (12.8,37.3) | 35 (12.6,58.0) | 13 (9.5,17.4) | 17 (11.3,23.1) |
 DR% (CI) for 10% FPR | 33 (25.1,40.6) | 42 (27.7,55.6) | 35 (12.6,58.0) | 19 (14.8,24.0) | 25 (18.1,31.6) |
 DR% (CI) for 20% FPR | 55 (46.8,63.2) | 73 (60.4,85.5) | 65 (42.0,87.4) | 35 (29.8,40.9) | 40 (32.5,47.8) |
T2 Biochemical Markers b | |||||
 AUC | 0.69 (0.620,0.755) | 0.76 (0.645,0.873) | 0.83 (0.608,1.000) | 0.58 (0.531,0.638) | 0.65 (0.581,0.725) |
 DR% (CI) for 5% FPR | 23 (13.2,32.1) | 29 (11.0,47.4) | 50 (15.4,84.6) | 12 (6.7,18.0) | 19 (9.8,28.5) |
 DR% (CI) for 10% FPR | 31 (20.2.41.1) | 42 (21.9,61.4) | 63 (29.0,96.0) | 20 (13.1,26.9) | 29 (18.6,40.2) |
 DR% (CI) for 20% FPR | 44 (32.8,55.2) | 58 (38.6,78.1) | 88 (64.6,100.0) | 28 (20.7,36.2) | 38 (26.9,49.8) |
Maternal Characteristics Only c | |||||
 AUC | 0.70 (0.661,0.745) | 0.71 (0.632,0.779) | 0.68 (0.558,0.806) | 0.74 (0.707,0.771) | 0.55 (0.510,0.594) |
 DR% (CI) for 5% FPR | 18 (11.9,24.5) | 15 (4.7,25.0) | 18 (0,35.8) | 22 (17.1,26.9) | 7 (3.2,11.5) |
 DR% (CI) for 10% FPR | 31 (23.2,38.3) | 30 (16.7,42.9) | 18 (0,35.8) | 34 (28.7,39.9) | 15 (9.6,21.1) |
 DR% (CI) for 20% FPR | 45 (36.6.52.9) | 47 (32.5,61.1) | 41 (17.8,64.6) | 54 (48.3,60.0) | 25 (18.4,32.3) |
Maternal Characteristics c + T1 PlGF + T1 PAPP-A | |||||
 AUC | 0.78 (0.740,0.821) | 0.83 (0.778,0.890) | 0.82 (0.702,0.944) | 0.75 (0.723,0.787) | 0.61 (0.560,0.660) |
 DR% (CI) for 5% FPR | 30 (22.2,37.6) | 35 (21.0,48.6) | 41 (17.8,64.6) | 23 (18.2,28.4) | 15 (9.3,20.9) |
 DR% (CI) for 10% FPR | 42 (33.3,49.9) | 52 (37.7,66.6) | 65 (42.0,87.4) | 39 (33.6,45.4) | 21 (14.6,27.9) |
 DR% (CI) for 20% FPR | 60 (51.7,68.1) | 67 (53.8,80.9) | 76 (56.3,96.6) | 58 (52.0,63.8) | 36 (28.5,44.1) |
Maternal Characteristics c + All T1 Biochemical Markers a | |||||
 AUC | 0.79 (0.749,0.828) | 0.84 (0.780,0.897) | 0.84 (0.725,0.960) | 0.76 (0.728,0.791) | 0.64 (0.589,0.691) |
 DR% (CI) for 5% FPR | 30 (22.2,37.6) | 37 (23.0,50.9) | 47 (23.3,70.8) | 24 (18.6,28.8) | 19 (12.8,25.6) |
 DR% (CI) for 10% FPR | 45 (36.9,53.6) | 59 (44.5,72.9) | 71 (48.9,92.3) | 40 (34.3,46.1) | 29 (21.4,36.1) |
 DR% (CI) for 20% FPR | 59 (50.9,67.4) | 72 (58.7,84.8) | 82 (64.2,100.0) | 59 (52.7,64.6) | 40 (31.8,47.7) |
Maternal Characteristics c + All T2 Biochemical Markers b | |||||
 AUC | 0.78 (0.723,0.836) | 0.80 (0.703,0.901) | 0.83 (0.594,1.000) | 0.76 (0.713,0.807) | 0.70 (0.621,0.779) |
 DR% (CI) for 5% FPR | 27 (17.2,37.6) | 39 (19.2,59.0) | 75 (45.0,100.0) | 29 (20.8,37.3) | 18 (7.7,27.4) |
 DR% (CI) for 10% FPR | 38 (27.2,49.5) | 48 (27.4,68.2) | 75 (45.0,100.0) | 40 (31.3,49.1) | 37 (24.3,49.4) |
 DR% (CI) for 20% FPR | 63 (51.9,74.1) | 65 (45.8,84.7) | 75 (45.0,100.0) | 56 (47.4,65.4) | 58 (45.1,70.7) |