Skip to main content

Table 3 Logistic regression coefficient and standard error for the prediction of adverse pregnancy outcomes using maternal characteristics and biochemical markers

From: Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia

Marker

Preeclampsia

Gestational hypertension

Preterm birth

 

All

Preterm

Early-onset

  
 

Coefficient

SE

Coefficient

SE

Coefficient

SE

Coefficient

SE

Coefficient

SE

T1 Biochemical Markersa

 Intercept

-1.1692¶

0.3565

-1.1523NS

0.5985

-1.6729%

0.7381

-1.1012*

0.2421

-1.9447*

0.3125

 PAPP-A

-0.7193^

0.1853

-1.5537*

0.3874

-

-

-0.4694*

0.1200

-0.3024%

0.1464

 free-β hCG

-0.4488¶

0.1551

-0.6470%

0.2718

-

-

-0.2657¶

0.1020

-

-

 PlGF

-0.9420^

0.2780

-1.3867¶

0.5224

-3.3491^

0.9404

-0.3503%

0.1767

-0.5498%

0.2334

 AFP

0.1868%

0.0898

-

-

-

-

-

-

0.3657^

0.1094

 Inhibin A

0.5241^

0.1566

0.8701^

0.2274

-

-

0.4195¶

0.1290

-

 

T2 Biochemical Markersb

 Intercept

-1.5231*

0.3796

-2.5203*

0.6174

-2.8837¶

1.0162

-2.2967*

0.2990

-3.9344*

0.3311

 AFP

-

−

-

-

-

-

0.7503^

0.2113

1.2020*

0.2441

 uE3

-

−

-

-

-

-

-

-

-

−

 hCG

0.5895*

0.1483

0.5332¶

0.1899

0.6212%

0.2678

-

-

-

−

 PAPP-A

-0.6405%

0.2501

-

-

-

-

-0.3987%

0.1841

-

−

 PlGF

-1.0464^

0.3104

-1.9338¶

0.6259

-3.1643%

1.2555

-

-

-

−

Maternal Characteristicsc + T1 PlGF + T1 PAPP-A

 Intercept

-6.9419*

1.0096

-5.2600¶

1.6327

-5.7611%

2.4117

-6.2080*

0.7445

-1.7145*

0.2782

 PlGF

-0.9925^

0.2829

-1.7875¶

0.5428

-2.8433¶

0.9518

-0.3273NS

0.1913

-0.4626NS

0.2366

 PAPP-A

-0.9265*

0.1927

-1.5843*

0.4034

-1.1291NS

0.6044

-0.6066*

0.1303

-0.4302¶

0.1575

Maternal Characteristicsc + All T1 Biochemical Markers a

 Intercept

-7.4496*

1.0422

-5.9671^

1.7274

-6.2326%

2.5740

-6.5085*

0.7625

-2.0900*

0.3673

 PAPP-A

-0.9335*

0.1960

-1.6698*

0.4025

-1.1970%

0.5981

-0.6177*

0.1337

-0.3836%

0.1607

 free-β hCG

-0.3955%

0.1607

-0.5637%

0.2787

-0.2477NS

0.3872

-0.1426NS

0.1038

-0.0709NS

0.1302

 PlGF

-0.7713¶

0.2817

-1.2278%

0.5345

-2.4894%

0.9844

-0.2676NS

0.1912

-0.4342NS

0.2397

 AFP

0.2180%

0.1004

0.1505NS

0.2163

-0.0942NS

0.4392

0.1697%

0.0863

0.3204¶

0.1102

 Inhibin A

0.4649¶

0.1652

0.8114^

0.2419

0.5278NS

0.3822

0.2345NS

0.1443

0.0016NS

0.1835

Maternal Characteristicsc + All T2 Biochemical Markers b

 Intercept

-5.5285*

1.3954

-1.1855NS

2.3472

-3.1794NS

3.9327

-7.2465*

1.1403

-2.9484*

0.7141

 AFP

-0.4117NS

0.3438

-0.7740NS

0.5826

-1.1304NS

1.1195

0.4014%

0.2567

0.9651¶

0.3051

 uE3

-0.4744NS

0.5340

-0.9717NS

0.9421

-1.9243NS

1.6075

-0.0260NS

0.4512

-0.5001NS

0.5564

 hCG

0.6030^

0.1700

0.9158^

0.2644

0.7432NS

0.4389

0.2084NS

0.1527

0.1450NS

0.2074

 PAPP-A

-0.8083¶

0.2598

-0.8946%

0.4279

0.3250NS

0.5517

-0.6117¶

0.2133

-0.5368 NS

0.3105

 PlGF

-1.0086¶

0.3186

-1.4560%

0.5983

-3.0874%

1.2967

-0.3119NS

0.2161

-0.3736NS

0.2901

  1. *p < 0.0001; ^ p < 0.001; ¶ p < 0.01; % p < 0.05; NS Not significant, The significance levels of the differences are reported in respect to the control group
  2. SE Standard error
  3. PAPP-A pregnancy-associated plasma protein A, hCG human chorionic gonadotropin, PlGF placental growth factor, AFP alpha feto-protein, uE3 unconjugated Estriol
  4. aFirst Trimester (T1) Biochemical Markers: PAPP-A, free-β hCG,PlGF, AFP, Inhibin A
  5. bSecond Trimester (T2) Biochemical Markers: AFP, uE3, hCG, PAPP-A, PlGF
  6. cThrough backward selection significant maternal characteristics for each case group were identified. Significant maternal characteristics for each case group include—All PE: age, weight, ethnicity, nulliparous; Preterm PE: age, weight, ethnicity, gravidity; Early-onset PE: age, gravidity; Gestational Hypertension: age, weight, ethnicity, nulliparous; Preterm Birth: nulliparous
Back to article page

BMC Pregnancy and Childbirth

ISSN: 1471-2393

Contact us