From: Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia
Maternal Characteristics | Preeclampsia | Gestational hypertension (n = 295) | Preterm birth (n = 166) | Controls (n = 1815) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
All (n = 147) | Preterm (n = 49) | Early-onset (n = 17) |  |  |  | |||||||
n | Median (5th,95th percentile) /Proportion(%) | n | Median (5th,95th percentile) / Proportion (%) | n | Median (5th,95th percentile) / Proportion(%) | n | Median (5th,95th percentile) / Proportion(%) | n | Median (5th,95th percentile) / Proportion(%) | n | Median (5th,95th percentile) / Proportion(%) | |
Maternal age, years | 147 | 34.1NS (26.5-40.9) | 49 | 34.9NS (26.0-42.8) | 17 | 34.4NS (28.1-41.6) | 295 | 33.5NS (26.4-41.4) | 166 | 33.9NS (24.9-41.7) | 1815 | 33.5 (26.3-39.9) |
Maternal weight, kg | 146 | 66.0* (48.6-113.2) | 49 | 65.4% (47.7-98.6) | 17 | 65.5NS (42.3-97.7) | 282 | 71.5* (50.8-110.0) | 161 | 60.5NS (45.5-92.7) | 1772 | 60.5 (46.8-88.5) |
Maternal BMI, kg/M2 | 124 | 25.7* (18.7-43.1) | 37 | 25.2% (18.6-36.0) | 13 | 24.8NS (17.9-32.4) | 264 | 26.3* (19.5-38.5) | 134 | 23.3NS (17.6-35.3) | 1560 | 22.4 (17.9-32.9) |
Gestational age at birth, weeks | 147 | 37.0* (32.0-40.0) | 49 | 35.0* (28.0-36.0) | 17 | 33.0* (23.0-33.0) | 295 | 38.0* (36.0-40.0) | 166 | 31.0* (20.0-33.0) | 1815 | 39.0 (37.0-41.0) |
Gestational age 1st sample scan, days | 143 | 88.0NS (81.0-93.0) | 48 | 87.0NS (81.0-93.0) | 17 | 87.0NS (81.0-93.0) | 286 | 88.0NS (82.0-92.0) | 158 | 87.0NS (81.0-93.0) | 1769 | 88.0 (82.0-93.0) |
Gestational age 2nd sample scan, days | 125 | 114.0NS (107.0-128.0) | 43 | 114.0NS (107.0-131.0) | 15 | 117.0NS (107.0-134.0) | 223 | 114.0NS (107.0-130.0) | 128 | 115.0NS (106.0-129.0) | 1404 | 114.0 (107.0-128.0) |
Ethnicity | ||||||||||||
 Caucasian | 36 | 24.5NS | 8 | 16.3NS |  < 6 | -NS | 111 | 37.6NS | 50 | 30.1NS | 589 | 32.5 |
 Asian | 85 | 57.8 | 35 | 71.4 | 12 | 70.6 | 154 | 52.2 | 90 | 54.2 | 983 | 54.2 |
 Black | 16 | 10.9 |  < 6 | - | 0 | 0 | 19 | 6.4 | 11 | 6.6 | 137 | 7.5 |
 Other/ Unknown | 10 | 6.8 |  < 6 | - |  < 6 | - | 11 | 3.7 | 15 | 9.0 | 106 | 5.8 |
Medical History | ||||||||||||
 Chronic hypertension | 40 | 27.2* | 11 | 22.4* |  < 6 | -* | 20 | 6.8* | 0 | 0 |  < 6 | - |
 Diabetes Type 1 |  < 6 | NS | 0 | 0 | 0 | 0 | 0 | 0 |  < 6 | -NS |  < 6 | - |
 Diabetes Type 2 |  < 6 | -% | 0 | 0 | 0 | 0 |  < 6 | -NS | 0 | 0 | 6 | 0.33 |
 APS/SLE | 0 | 0 | 0 | 0 | 0 | 0 |  < 6 | -% |  < 6 | -NS | 0 | 0 |
 Smoking |  < 6 | -NS | 0 | 0 | 0 | 0 | 10 | 3.4NS |  < 6 | -NS | 31 | 1.7 |
Graviditya,b | ||||||||||||
 1 | 65 | 45.1^ | 22 | 46.8% | 8 | 47.1NS | 116 | 40^ | 51 | 32.9NS | 534 | 30.0 |
Parityb, c | ||||||||||||
 Nulliparous | 90 | 62.5* | 27 | 57.4% | 9 | 52.9NS | 164 | 56.6* | 80 | 51.6 ¶ | 729 | 41.0 |
 IVF |  < 6 | -NS |  < 6 | -NS | 0 | 0 | 11 | 3.7 ¶ |  < 6 | -NS | 25 | 1.4 |
Pregnancy Outcome d | ||||||||||||
 Live Birth | 146 | 99.3NS | 48 | 98.0% | 16 | 94.1 ¶ | 295 | 100 | 120 | 72.3* | 1815 | 100 |