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Table 1 Maternal characteristics, medical history, and pregnancy outcomes among case and control groups

From: Modified multiple marker aneuploidy screening as a primary screening test for preeclampsia

Maternal

Characteristics

Preeclampsia

Gestational hypertension (n = 295)

Preterm birth

(n = 166)

Controls

(n = 1815)

All (n = 147)

Preterm (n = 49)

Early-onset (n = 17)

   

n

Median

(5th,95th percentile)

/Proportion(%)

n

Median

(5th,95th percentile)

/ Proportion (%)

n

Median

(5th,95th percentile)

/ Proportion(%)

n

Median

(5th,95th percentile)

/ Proportion(%)

n

Median

(5th,95th percentile)

/ Proportion(%)

n

Median

(5th,95th percentile)

/ Proportion(%)

Maternal age, years

147

34.1NS

(26.5-40.9)

49

34.9NS

(26.0-42.8)

17

34.4NS

(28.1-41.6)

295

33.5NS

(26.4-41.4)

166

33.9NS

(24.9-41.7)

1815

33.5

(26.3-39.9)

Maternal weight, kg

146

66.0*

(48.6-113.2)

49

65.4%

(47.7-98.6)

17

65.5NS

(42.3-97.7)

282

71.5*

(50.8-110.0)

161

60.5NS

(45.5-92.7)

1772

60.5

(46.8-88.5)

Maternal BMI, kg/M2

124

25.7*

(18.7-43.1)

37

25.2%

(18.6-36.0)

13

24.8NS

(17.9-32.4)

264

26.3*

(19.5-38.5)

134

23.3NS

(17.6-35.3)

1560

22.4

(17.9-32.9)

Gestational age at birth, weeks

147

37.0*

(32.0-40.0)

49

35.0*

(28.0-36.0)

17

33.0*

(23.0-33.0)

295

38.0*

(36.0-40.0)

166

31.0*

(20.0-33.0)

1815

39.0

(37.0-41.0)

Gestational age 1st sample scan, days

143

88.0NS

(81.0-93.0)

48

87.0NS

(81.0-93.0)

17

87.0NS

(81.0-93.0)

286

88.0NS

(82.0-92.0)

158

87.0NS

(81.0-93.0)

1769

88.0

(82.0-93.0)

Gestational age 2nd sample scan, days

125

114.0NS

(107.0-128.0)

43

114.0NS

(107.0-131.0)

15

117.0NS

(107.0-134.0)

223

114.0NS

(107.0-130.0)

128

115.0NS

(106.0-129.0)

1404

114.0

(107.0-128.0)

Ethnicity

 Caucasian

36

24.5NS

8

16.3NS

 < 6

-NS

111

37.6NS

50

30.1NS

589

32.5

 Asian

85

57.8

35

71.4

12

70.6

154

52.2

90

54.2

983

54.2

 Black

16

10.9

 < 6

-

0

0

19

6.4

11

6.6

137

7.5

 Other/

Unknown

10

6.8

 < 6

-

 < 6

-

11

3.7

15

9.0

106

5.8

Medical History

 Chronic hypertension

40

27.2*

11

22.4*

 < 6

-*

20

6.8*

0

0

 < 6

-

 Diabetes Type 1

 < 6

NS

0

0

0

0

0

0

 < 6

-NS

 < 6

-

 Diabetes

Type 2

 < 6

-%

0

0

0

0

 < 6

-NS

0

0

6

0.33

 APS/SLE

0

0

0

0

0

0

 < 6

-%

 < 6

-NS

0

0

 Smoking

 < 6

-NS

0

0

0

0

10

3.4NS

 < 6

-NS

31

1.7

Graviditya,b

 1

65

45.1^

22

46.8%

8

47.1NS

116

40^

51

32.9NS

534

30.0

Parityb, c

 Nulliparous

90

62.5*

27

57.4%

9

52.9NS

164

56.6*

80

51.6 ¶

729

41.0

 IVF

 < 6

-NS

 < 6

-NS

0

0

11

3.7 ¶

 < 6

-NS

25

1.4

Pregnancy Outcome d

 Live Birth

146

99.3NS

48

98.0%

16

94.1 ¶

295

100

120

72.3*

1815

100

  1. *p < 0.0001; ^ p < 0.001; ¶ p < 0.01; % p < 0.05; NS Not significant. The significance levels of the differences are reported in respect to the control group
  2. Comparison between case and control groups: Chi-Square or Fisher’s exact test for categorical variables; Mann-Whitney U test for continuous variables
  3. BMI, Body Mass Index
  4. aGravidity is a binary variable categorized as 1 or > 1
  5. bParity and Gravidity were missing among cases and controls: 3 missing among all preeclampsia cases(n = 144), 2 missing among preterm preeclampsia cases (n = 47), 5 missing among gestational hypertension cases(n = 290), 11 missing among preterm birth cases(n = 155), and 35 missing among controls(n = 1780)
  6. cParity is a binary variable categorized as nulliparous or parous
  7. d Pregnancy Outcome is a binary variable categorized as live birth or stillbirth/pregnancy loss